A5041736325- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Lipids, and Metabolism
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- PI3K/AKT/mTOR signaling in cancer
- Metabolomics and Mass Spectrometry Studies
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Genomics, phytochemicals, and oxidative stress
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Plant Diversity and Evolution
- Vascular Tumors and Angiosarcomas
- Mast cells and histamine
- interferon and immune responses
- Mitochondrial Function and Pathology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Liver physiology and pathology
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Extracellular vesicles in disease
- Food Allergy and Anaphylaxis Research
- Garlic and Onion Studies
Shanghai Cancer Institute
2014-2025
Eastern Hepatobiliary Surgery Hospital
2014-2024
Second Military Medical University
2014-2024
Nanjing Forestry University
2023-2024
Capital Medical University
1993-2024
University of South China
2021-2024
China Agricultural University
2019-2022
Ruijin Hospital
2021
Shanghai Jiao Tong University
2021
Shanghai Institute of Hematology
2021
Introduction Cholangiocarcinoma (CCA) is a malignant tumor of the biliary epithelium with poor prognosis. The lack biomarkers to predict therapeutic response and prognosis one major challenges for CCA treatment. Tertiary lymphoid structures (TLS) provide local pivotal microenvironment immune responses. prognostic value clinical relevance TLS in remain unclear. We aimed explore characteristics significance CCA. Methods investigated using surgery cohort containing 471 patients (cohort 1) an...
Abstract The treatment of hepatocellular carcinoma (HCC) is particularly challenging due to the inherent tumoral heterogeneity and easy resistance towards chemotherapy immunotherapy. Arsenic trioxide (ATO) has emerged as a cytotoxic agent effective for treating solid tumors, including advanced HCC. However, its effectiveness in HCC remains limited, underlying mechanisms are still uncertain. Therefore, this study aimed characterize effects ATO By evaluating susceptibilities human murine cell...
Patient-derived xenografts (PDXs) and PDX-derived cells (PDCs) are useful in preclinical research. We performed a drug screening assay using PDCs identified proteasome inhibitors as promising drugs for cholangiocarcinoma (CCA) treatment. Furthermore, we determined that phosphate tensin homology deleted on chromosome ten (PTEN) deficiency promotes protein synthesis subunit expression proteolytic activity, creating dependency the cancer cell growth survival. Thus, targeting machinery with...
Gemcitabine is a nucleoside analog that has been successfully used in the treatment of multiple cancers. However, intrinsic or acquired resistance reduces chemotherapeutic potential gemcitabine. Here, we revealed previously unappreciated mechanism by which phosphatase and tensin homolog (PTEN), one most frequently mutated genes human cancers, dominates decision-making process central to regulation gemcitabine efficacy cholangiocarcinoma (CCA). By investigating gemcitabine-treated CCA cohort,...
Abstract Background Adipose tissue plays a pivotal role in systemic metabolism and maintaining bodily homeostasis. Exosomes from adipose tissues, known as AT-Exos, are recognized important messengers the communication between other organs. Despite this, alterations exosome composition functional disparities among depot-specific AT-Exos obesity remain elusive. Methods In this work, we utilized lipidomics microRNA (miRNA) sequencing to elucidate lipid miRNA profiles of diet-induced model. We...
BACKGROUND The functions of cytoskeleton‐associated membrane protein 4 (CKAP4), one kind type II transmembrane protein, are associated with the palmitoyl acyltransferase DHHC2. objective current study was to investigate CKAP4/DHHC2 expression and its prognostic significance in patients hepatocellular carcinoma (HCC). METHODS Two independent cohorts 416 HCC were enrolled. All included had defined clinicopathologic follow‐up data. Using real‐time polymerase chain reaction immunohistochemical...
Hepatocarcinogenesis is frequently accompanied by substantial metabolic reprogramming to maximize the growth and proliferation of cancer cells. In this study, we carried out a comprehensive study metabolomics lipidomics profiles combined with gene expression analysis characterize in hepatocellular carcinoma (HCC). Compared adjacent noncancerous liver tissue, enhanced aerobic glycolysis de novo lipogenesis (DNL) repressed urea cycle were underscored HCC tissue. Furthermore, multiscale...
Intrahepatic cholangiocarcinoma (ICC) is characterized by a dismal prognosis with limited therapeutic alternatives. To explore phosphatase and tension homolog (PTEN) as biomarker for proteasome inhibition in ICC, we conducted phase II trial to assess the second-line efficacy of bortezomib PTEN-deficient advanced ICC patients.
CKAP4, one kind of type II trans-membrane protein, plays an important role to maintain endoplasmic reticulum structure and inhibits the proliferation bladder cancer cells by combining its ligand anti-proliferative factor (APF). However, biological function CKAP4 in progression liver has not been clearly demonstrated. In present study, we knocked down or overexpressed hepatocellular carcinoma (HCC) cell proliferation, invasion, migration capacities were investigated CCK-8 transwell assays....
Background and Aims Cancer cell survival depends on the balance between reactive oxygen species production scavenging, which is regulated primarily by NRF2 during tumorigenesis. Here, we demonstrate that deletion of RBP5‐mediating protein (RMP) in an autonomous mouse model intrahepatic cholangiocarcinoma (ICC) delays tumor progression. Approach Results RMP‐overexpressing cells exhibited enhanced tolerance to oxidative stress apoptosis. Mechanistically, RMP competes with for binding Kelch...
// Jian Zhang 1,2,5,* , Tian-Yi Jiang 1,2,* Bei-Ge 3,* Chun Yang Ye-Xiong Tan 1,2 Ning 3 Yu-Fei Pan Zhi-Wen Ding Guang-Zhen 1 Meng-Chao Wu Li-Wei Dong and Hong-Yang Wang 1,2,4 International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, The Second Military Medical University, Shanghai, P. R. China 2 National Center for Liver Cancer, P.R. Department of Surgery, Hospital, 4 State Key Oncogenes related Genes, Shanghai Cancer Renji Jiaotong University...
Assessment and prediction of prognostic risk in patients with hepatocellular carcinoma (HCC) would greatly benefit the optimal treatment selection. Here, we aimed to identify critical metabolites associated outcomes develop a score assess prognosis HCC after curative resection. A total 78 serum samples were analyzed by liquid chromatography–mass spectrometry characterize metabolic profiling. novel network-based feature selection method (NFSM) was developed define most discriminant capacity...
Abstract NRF2 is the master transcriptional activator of cytoprotective genes and Kelch-like ECH-associated protein 1 (Keap1), a biosensor for electrophiles oxidation, promotes degradation in unstressed conditions. SQSTM1/p62, an oncogenic aberrantly accumulated hepatocellular carcinoma (HCC), binds sequestrates Keap1, leading to prevention degradation. Here, we show that p15INK4b-related sequence/regulation nuclear pre-mRNA domain-containing 1A (RPRD1A) highly expressed HCC tumors...
Oncogene-derived metabolic reprogramming is important for anabolic growth of cancer cells, which now considered to be not simply rely on glycolysis. Pentose phosphate pathway and tricarboxylic acid cycle also play pivotal roles in helping cells meet their energy demands. The present work focused gankyrin, a relatively specific oncogene hepatocellular carcinoma (HCC), its impact glycolysis mitochondrial homeostasis. Metabolomics, RNA-seq analysis, subsequent conjoint analysis illustrated that...