Xiaodong Zhu

ORCID: 0000-0001-5462-2057
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About
Contact & Profiles
Research Areas
  • Spinal Fractures and Fixation Techniques
  • Scoliosis diagnosis and treatment
  • Spine and Intervertebral Disc Pathology
  • Pelvic and Acetabular Injuries
  • Sepsis Diagnosis and Treatment
  • Medical Imaging and Analysis
  • Musculoskeletal pain and rehabilitation
  • Neonatal Respiratory Health Research
  • Acute Kidney Injury Research
  • Immune Response and Inflammation
  • Respiratory viral infections research
  • Hemodynamic Monitoring and Therapy
  • Antimicrobial Resistance in Staphylococcus
  • Ethics and Legal Issues in Pediatric Healthcare
  • Antibiotics Pharmacokinetics and Efficacy
  • Respiratory Support and Mechanisms
  • Neonatal and Maternal Infections
  • Spinal Hematomas and Complications
  • Antifungal resistance and susceptibility
  • Pharmaceutical studies and practices
  • Child and Adolescent Health
  • Pneumonia and Respiratory Infections
  • Cardiac Valve Diseases and Treatments
  • Nosocomial Infections in ICU
  • Spinal Dysraphism and Malformations

ResMed (Australia)
2024

Shandong Provincial Hospital
2024

Shandong First Medical University
2024

XinHua Hospital
2014-2024

Tumor Hospital of Guangxi Medical University
2024

Inner Mongolia University
2023

Tongren Hospital
2015-2020

Shanghai Jiao Tong University
2014-2020

Second Military Medical University
2009-2018

Changhai Hospital
2009-2018

Patients with metastatic gastric cancer (mGC) who do not respond to or experience progression second-line chemotherapy have no treatment options that clearly confer a survival benefit. This trial investigated the safety and efficacy of apatinib, an inhibitor vascular endothelial growth factor receptor, as option for heavily pretreated patients mGC.Patients experienced failure at least two chemotherapeutic regimens were randomly assigned receive placebo (group A), apatinib 850 mg once daily...

10.1200/jco.2013.48.8585 article EN Journal of Clinical Oncology 2013-08-06

A retrospective radiographic study.To investigate which preoperative parameters best correlate with the angulation and translation of lowest instrumented vertebra (LIV) global coronal balance after posterior spinal pedicle screw fixation for thoracolumbar/lumbar (TL/L) adolescent idiopathic scoliosis.Lenke 5C patients a single, structural TL/L curve can be treated by either an anterior or approach. One operative goals when treating Lenke is to level center LIV, thereby achieving better...

10.1097/brs.0b013e3182091fba article EN Spine 2011-02-25

A single-center, retrospective study of 39 consecutive patients with Lenke 5 adolescent idiopathic scoliosis (AIS), all operated by a single surgeon using identical surgical technique and type instrumentation (pedicle screws).The objective this is to evaluate the effect implant density on coronal sagittal correction in treatment AIS.There an increasing trend use pedicle screws spinal corrective surgery. It reported that decreased numbers (low screw density) have no effects clinical outcomes...

10.1097/brs.0b013e318297bfd4 article EN Spine 2013-04-24

To investigate the incidence rates of candidemia in hospitalized patients and to identify differences risk factors with Candida albicans non-C. guilliermondii candidemia.Non-immunosuppressed, non-neutropenic inpatients diagnosed after admission were included this retrospective observational study at a tertiary academic hospital China.During period (January 2009 December 2011), 238 eligible had episodes an rate 5.4%. Of these patients, 29.8% due C. albicans, 27.7% parapsilosis, 16.4%...

10.1016/j.ijid.2013.11.011 article EN cc-by-nc-sa International Journal of Infectious Diseases 2014-02-28

In Brief Study Design. Retrospective review of anterior and posterior fusions for treatment Lenke5C adolescent idiopathic scoliosis (AIS). Objective. To compare the clinical radiographic results versus pedicle screw instrumentation in AIS. Summary Background Data. Anterior instrumentations are 2 established methods correcting However, there few reports that methods. Methods. Forty-six consecutive patients with AIS curves underwent selective lumbar or thoracolumbar fusion (1999-2005)....

10.1097/brs.0b013e31819e2b16 article EN Spine 2009-05-01

Prospective clinical study.The aim of this study was to compare postoperative outcome in patients with Lenke 1 adolescent idiopathic scoliosis (AIS) after posterior correction and fusion consecutive or interval pedicle screw constructs on the side.Despite reports satisfactory maintenance scoliotic curves instrumentation side, there has been no comparison versus placement.Thirty AIS were randomly divided into 2 groups. In group, performed using placement whereas other, an construct employed....

10.1097/bsd.0b013e3181884940 article EN Journal of Spinal Disorders & Techniques 2009-05-29

BACKGROUND: Anterior lumbar interbody fusion and posterior with 1 cage have been shown to similar biomechanics compared the use of 2 cages. However, there no reports on biomechanical differences between using or cages in transforaminal (TLIF) surgery. OBJECTIVE: To determine TLIF by finite-element analysis. METHODS: Three validated models L3-L5 segment were created (intact model single- paired-cage models). study biomechanics, a compressive preload 400 N over 7.5 N-m was applied superior...

10.1227/01.neu.0000430320.39870.f7 article EN Operative Neurosurgery 2013-04-30

Studies have shown that lumbar disc herniation, degenerative instability, and other spinal diseases are often secondary to degeneration. By studying the intervertebral disc, researchers clarified pathological changes involved in degeneration but ignored roles of biomechanical factors development This study aims investigate relationships among location, scope, extent sagittal spinal-pelvic parameters. A retrospective analysis was performed on clinical data 284 patients with (lumbar herniation...

10.1186/s13018-018-0838-6 article EN cc-by Journal of Orthopaedic Surgery and Research 2018-06-04

In Brief Study Design. Validation study to define validity and reliability of an adapted translated questionnaire. Objective. This attempted validate the traditional Chinese (Hong Kong) version modified Scoliosis Research Society (SRS) Outcomes Instrument, SRS-22, into simplified for use in mainland China. Summary Background Data. Although a adaptation SRS-22 has been previously validated, no culturally adapted, validated exists Methods. Adhering International Quality Life Assessment Project...

10.1097/brs.0b013e31819812b7 article EN Spine 2009-05-01

Object The authors evaluated the effectiveness of Lenke Type 2 criteria in scoliosis correction with segmental pedicle screw (PS) technique, emphasis on shoulder balance. Methods Twenty-five consecutive patients (structural double thoracic curves, sidebending Cobb angle > 25°, or T2–5 kyphosis 20°) who underwent PS instrumentation were included this study. At surgery, an average 14.1 years age, and duration follow-up was 2.9 years. For radiological evaluation patients, preoperative,...

10.3171/2008.11.spine08524 article EN Journal of Neurosurgery Spine 2009-03-01

BACKGROUND: Transverse patella fractures are the most common type of fractures. Minimally invasive surgical technique for treatment transverse with Cable Pin System has not been previously reported. METHODS: Thirty-four patients displaced were included in this prospective study and operatively treated by a minimally technique. Postoperative evaluation was based on radiographs, Visual Analog Scale pain, range motion, Bostman grading scale. RESULTS: A total 31 finally included, an average...

10.1097/ta.0b013e318240d728 article EN Journal of Trauma and Acute Care Surgery 2012-04-01

A retrospective study.The aim of this study was to detect risk factors for Adding-on after posterior correction surgery in patients with Lenke 1 or 2 AIS, and explore whether Index could be used predict effectively.Adding-on phenomenon is a common complication AIS surgery. However, it can predicted remains unknown.Lenke receiving our center from January 2009 July 2013 were analyzed. Antero-posterior lateral films evaluated before surgery, at weeks' years' follow-up. Patients divided into...

10.1097/brs.0000000000001303 article EN Spine 2015-12-02

Continuous renal replacement therapy becomes available utilization for pediatric critically ill, but the impact of mortality rate in severe sepsis remains no consistent conclusion. The aim study is to assess effect continuous patients with and this may have on their mortality.Propensity score-matched cohort analyzing data prospectively collected by PICUs over 2 years (2016-2018).Four tertiary university children's hospital China.The consecutive admitted were enrolled from July 2016 June...

10.1097/ccm.0000000000003901 article EN cc-by-nc-nd Critical Care Medicine 2019-08-01

Selective fusion of the thoracolumbar/lumbar (TL/L) curve is an effective method for treatment Lenke type 5C curves. Several studies have demonstrated that spontaneous correction thoracic does indeed occur. However, how this occurs after isolated posterior segmental instrumentation structural lumbar has not been well described. The aim study was to evaluate response selective TL/L in patients with adolescent idiopathic scoliosis (AIS) and assess correlative clinical outcomes. Thirty-four...

10.1097/md.0000000000001155 article EN cc-by-nc Medicine 2015-07-01

In this article, a retrospective analysis of 161 female patients with adolescent idiopathic scoliosis (AIS) is performed who underwent posterior correction and fusion using all-pedicle screw instrument. The aim article to find out preoperative factors that influence intraoperative blood loss (IOBL) in AIS. IOBL surgery for greatly varies. variables affecting the also vary among different studies. Medical records all AIS operations system our hospital from January 2012 2014 were reviewed....

10.1097/md.0000000000000359 article EN cc-by-nc Medicine 2015-01-01

Prospective randomized clinical trial.To compare the accuracy and time using of pedicle screw placement between electronic conductivity device (ECD) normal finder (NPF) in posterior surgery scoliosis, through a trial.Pedicle insertion for scoliosis correction can be associated with increased perforations. The malposition rates various techniques different region spine have been reported to occur frequency 3.3%-43%. An ECD has surgeries, but its surgical comparing NPF presence not...

10.1097/bsd.0b013e318247f21d article EN Journal of Spinal Disorders & Techniques 2012-02-07

Objective The causes of low back pain in China and Western countries are extremely different. We attempted to analyze the risk factors urban rural patients under dual economy with simplified Chinese version Roland-Morris disability questionnaire (SC-RMDQ) demonstrate that SC-RMDQ could evaluate arising from different causes. Methods was translated into SCRMDQ according international guidelines for adaptation. In this study, 187 outpatients inpatients (99 88 patients) were analyzed. All...

10.1371/journal.pone.0030807 article EN cc-by PLoS ONE 2012-01-27

To investigate the clinical effect of percutaneous pedicle screw fixation (PPSF) combined with vertebroplasty (PVP) in treatment osteoporotic compression vertebral fracture (OVCF) thoracolumbar vertebra kyphosis.One hundred sixty-six patients before June 2017 were retrospectively analyzed, and divided into PPSF + PVP group A B. Operative time, bone mineral density, postoperative bed high ratio, cement leakage rate, dose recorded. Comparison anterior edge height, Cobb angle, visual analogue...

10.1186/s13018-020-1583-1 article EN cc-by Journal of Orthopaedic Surgery and Research 2020-02-17

Abstract The identification of predictors for immunotherapy is often hampered by the absence control groups in many studies, making it difficult to distinguish between prognostic and predictive biomarkers. This study presents biomarker analyses from phase 3 CONTINUUM trial (NCT03700476), first show that adding anti-PD-1 (aPD1) chemoradiotherapy (CRT) improves event-free survival (EFS) patients with locoregionally advanced nasopharyngeal carcinoma. A dynamic single-cell atlas was profiled...

10.1038/s41392-024-01988-w article EN cc-by Signal Transduction and Targeted Therapy 2024-10-23

The following study was a prospective radiographic and retrospective clinical data assessment of adolescent idiopathic scoliosis (AIS) patients who had undergone key-vertebral screws strategy (KVSS) at single institution, with minimum 2 years' follow-up.The aim the to introduce KVSS for operative treatment AIS main thoracic curve, address role fulcrum-bending radiograph (FBR) in predicting outcome surgical management by this method.The application multilevel pedicle curve is popular an...

10.1097/bsd.0000000000000129 article EN Clinical Spine Surgery A Spine Publication 2014-07-30
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