A5082693457- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Bone Tissue Engineering Materials
- Bone Metabolism and Diseases
- Silk-based biomaterials and applications
- Synthesis of Tetrazole Derivatives
- Bone and Joint Diseases
- Titanium Alloys Microstructure and Properties
- Scoliosis diagnosis and treatment
- Bone Tumor Diagnosis and Treatments
- Polymer Surface Interaction Studies
- Musculoskeletal pain and rehabilitation
- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- MicroRNA in disease regulation
- Spine and Intervertebral Disc Pathology
- Sarcoma Diagnosis and Treatment
- Medicinal Plant Pharmacodynamics Research
- Antimicrobial Peptides and Activities
Shanghai Sixth People's Hospital
2017-2023
Shanghai Jiao Tong University
2017-2022
Tongren Hospital
2018
Icariin-loaded sulfonated PEEK can promote osteogenic differentiation and inhibit osteoclast by regulating macrophage polarization, thereby enhancing osseointegration.
Studies have shown that lumbar disc herniation, degenerative instability, and other spinal diseases are often secondary to degeneration. By studying the intervertebral disc, researchers clarified pathological changes involved in degeneration but ignored roles of biomechanical factors development This study aims investigate relationships among location, scope, extent sagittal spinal-pelvic parameters. A retrospective analysis was performed on clinical data 284 patients with (lumbar herniation...
Inflammatory osteolysis, a major complication of total joint replacement surgery, can cause prosthesis failure and necessitate revision surgery. Macrophages are key effector immune cells in inflammatory responses, but excessive M1-polarization dysfunctional macrophages leads to the secretion proinflammatory cytokines severe loss bone tissue. Here, we report development macrophage-biomimetic porous SiO2-coated ultrasmall Se particles (porous Se@SiO2 nanospheres) manage osteolysis.Macrophage...
Giant cell tumor (GCT) of bone is an aggressive skeletal characterized by localized resorption. MicroRNA-16-5p (miR-16-5p) has been reported to be downregulated in lesions patients with GCT, but little known about its role GCT. To explore the underlying function miR-16-5p we first detected expression The results showed that osteoclast formation increased, whereas considerably decreased severity destruction. Furthermore, found progression receptor activator nuclear factor-κB ligand- (RANKL-)...
The conventional method of applying local medications for treating wound infections is often ineffective because the dilution drugs by excess exudate. In addition, there have been insufficient studies investigating adhesion between drug-loaded nanomaterials and cells or tissue. To address this intractable problem, berberine–silk fibroin microspheres (Ber@MPs) with an extracellular matrix-anchoring function were developed in study. prepared from silk using polyethylene glycol emulsion...