A5100406938- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Prostate Cancer Treatment and Research
- Cancer Cells and Metastasis
- Hippo pathway signaling and YAP/TAZ
- Renal cell carcinoma treatment
- Ubiquitin and proteasome pathways
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Bladder and Urothelial Cancer Treatments
- Histone Deacetylase Inhibitors Research
- HER2/EGFR in Cancer Research
- Genetics and Neurodevelopmental Disorders
- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- Scoliosis diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Renal and related cancers
- Pelvic and Acetabular Injuries
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Radiopharmaceutical Chemistry and Applications
- Prostate Cancer Diagnosis and Treatment
- Immune cells in cancer
- Cerebrovascular and Carotid Artery Diseases
Nanjing Medical University
2020-2025
The First People's Hospital of Changde
2021-2025
Central South University
2022-2025
First Affiliated Hospital of Anhui Medical University
2022-2025
Chaohu Hospital of Anhui Medical University
2024-2025
Xianning Central Hospital
2024
Hubei University of Science and Technology
2024
Second Military Medical University
2013-2023
Chinese Academy of Sciences
2022-2023
Anhui Provincial Hospital
2023
Androgen receptor (AR) antagonists, such as enzalutamide, have had a major impact on the treatment of metastatic castration-resistant prostate cancer (CRPC). However, even with advent AR antagonist therapies, patients continue to develop resistance, and new strategies combat continued signalling are needed. Here, we degraders using PROteolysis TArgeting Chimeric (PROTAC) technology in order determine whether depletion protein can overcome mechanisms resistance commonly associated current...
Inflammation is highly associated with colon carcinogenesis. Epigenetic mechanisms could play an important role in the initiation and progression of cancer. Curcumin, a dietary phytochemical, shows promising effects suppressing colitis-associated cancer azoxymethane-dextran sulfate sodium (AOM-DSS) mice. However, potential epigenetic curcumin remain unknown. In this study, anticancer effect 18-week AOM-DSS mouse model was confirmed. We identified lists differentially expressed methylated...
Abstract Colorectal cancer (CRC) is a usual and kind of lethiferous cancer. Cuproptosis-related gene ferredoxin 1 (FDX1) has been discovered to act as suppressor, thereby suppressing some cancers’ progression. But, the regulatory functions FDX1 in CRC progression keep vague. In this work, at first, through TCGA database, it was revealed that exhibited lower expression COAD (colon adenocarcinoma) tissues, patients with had worse prognosis. Furthermore, verified be down-regulated tissues ( n =...
Purpose: Cancer stem-like cells (CSC) contribute to the progression and androgen deprivation therapy (ADT) resistance of prostate cancer. As CSCs depend on their specific niche, including tumor-associated macrophages (TAM), elucidating network between TAMs may help effectively inhibit ADT cancer.Experimental Design: The underlying intracellular mechanism that sustains characteristics in cancer was assessed via RNA sequencing, co-immunoprecipitation, chromatin immunoprecipitation, other...
Purpose: Androgen deprivation therapy (ADT), including enzalutamide, induces resistance in prostate cancer; ADT is associated with neuroendocrine differentiation (NED) and tumor-associated macrophages (TAM). This study aimed to investigate the association between enzalutamide-induced NED TAMs its mechanism.Experimental Design: The was investigated by IHC using cancer tissues, enzalutamide-resistant mouse xenografts, a coculture system. underlying mechanisms were assessed vitro cytokine...
Esophageal squamous cell carcinoma (ESCC) is the most difficult subtype of esophageal cancer to treat due a paucity effective targeted therapy. ESCC believed arise from tumour initiating cells (TICs), which contribute metastasis and chemoresistance. In this study, we found that Protein arginine methyltransferase 1(PRMT1) was highly expressed in ESCCs associated with aberrant clinicopathological characteristics patients. specimens, elevated expression PRMT1 OV6 significantly histologic grade,...
A single-center, retrospective study of 39 consecutive patients with Lenke 5 adolescent idiopathic scoliosis (AIS), all operated by a single surgeon using identical surgical technique and type instrumentation (pedicle screws).The objective this is to evaluate the effect implant density on coronal sagittal correction in treatment AIS.There an increasing trend use pedicle screws spinal corrective surgery. It reported that decreased numbers (low screw density) have no effects clinical outcomes...
Hepatitis B virus X protein (HBx) and cancer stem-like cells (CSCs) have both been implicated in the occurrence development of HBV-related hepatocellular carcinoma (HCC). However, whether HBx contributes to properties OV6+ CSCs HCC remains elusive. In this study, we showed that concomitant expression OV6 was closely associated with clinical outcomes prognosis patients HCC. required for liver CSCs, including self-renewal, stem cell-associated gene expression, tumorigenicity chemoresistance....
Oncogenic imbalance of DNA methylation is well recognized in cancer development. The ten-eleven translocation (TET) family dioxygenases, which facilitates demethylation, frequently dysregulated cancers. How such dysregulation contributes to tumorigenesis remains poorly understood, especially solid tumors present infrequent mutational incidence TET genes. Here, we identify loss-of-function mutations 7.4% human lung adenocarcinoma (LUAD), co-occur with oncogenic KRAS mutations, and this...
Tumor-associated macrophages (TAMs) are closely related to unfavorable prognosis of patients with clear cell renal carcinoma (ccRCC). However, the important molecules in interaction between ccRCC and TAMs unclear.TCGA-KIRC gene expression data tumor tissues normal adjacent were compared identify differentially expressed genes ccRCC. discovered by analyzing correlation these common macrophage biomarkers. Gene set enrichment analysis was performed predict functions gene. The findings further...
Although the interaction between tumors and tumor-associated macrophages (TAMs) has been reported to facilitate targeted drug resistance progression of clear cell renal carcinoma (ccRCC), related mechanisms remain unknown. Here, we report that SOX17 serves as a novel tumor suppressor in ccRCC positive regulatory loop, SOX17low/YAP/TEAD1/CCL5/CCR5/STAT3, facilitates ccRCC-TAM interaction. expression was commonly downregulated negatively correlated with TAM infiltration specimens, integration...
Abstract The poor prognosis of clear-cell renal cell carcinoma (ccRCC) patients is due to progression and targeted drug resistance, but the underlying molecular mechanisms need further elucidation. This study examined biological function related gankyrin in ccRCC based on results our previous study. To this end, vitro functional experiments; vivo models subcutaneous tumor formation, lung metastasis, orthotopic ccRCC; antibody chip detection, co-IP, ChIP assays were performed examine role...
Although androgen deprivation therapy (ADT) is a standard treatment for metastatic prostate cancer, this disease inevitably recurs and progresses to ADT‐resistant stage after therapy. Accordingly, understanding the mechanism of resistance ADT finding new approach enhance efficacy may provide major benefit PCa patients. In our study, we found upregulated expression Notch receptors positive associated with ADT‐resistance progression. Using fluorescent signaling reporter system, observed that...
Abstract Purpose: Cancer stem-like cells (CSCs) contribute to bladder cancer chemotherapy resistance and progression, but the associated mechanisms have not been elucidated. This study determined whether blocking an autocrine signaling loop in CSCs improves therapeutic effects of cis-platinum on cancer. Experimental Design: The expression epithelial marker OV6 other markers human specimens was examined by IHC. CSC properties magnetic-activated cell sorting (MACS)-isolated OV6+ OV6− were...
Colorectal cancer (CRC) is one common tumor with the high death rate, and badly affects normal lives of CRC patients. Amarogentin (AG) has been found to exhibit regulatory roles join into progression multiple diseases. However, impacts associated molecular mechanisms AG in keep unclear. In this study, it was demonstrated that weakened cell viability a concentration- time-dependent manner. addition, accelerated apoptosis by triggering ferroptosis. The invasion EMT process were restrained...
In this article, a retrospective analysis of 161 female patients with adolescent idiopathic scoliosis (AIS) is performed who underwent posterior correction and fusion using all-pedicle screw instrument. The aim article to find out preoperative factors that influence intraoperative blood loss (IOBL) in AIS. IOBL surgery for greatly varies. variables affecting the also vary among different studies. Medical records all AIS operations system our hospital from January 2012 2014 were reviewed....
Menin displays either tumor suppression or promotion functions in a context-dependent manner. Previously, we proposed that acts as suppressor by inhibiting cell growth pancreatic ductal adenocarcinoma (PDAC), whereas the relationship between expression and overall survival rate of PDAC patients has not been completely elucidated, indicating complexity progression. Here, identify promoter epithelial-mesenchymal transition (EMT), which is largely associated with migration metastasis, modest...