A5002310950- Circadian rhythm and melatonin
- Epigenetics and DNA Methylation
- Vitamin D Research Studies
- Neonatal Respiratory Health Research
- Genetics, Aging, and Longevity in Model Organisms
- Estrogen and related hormone effects
- Asthma and respiratory diseases
- Air Quality and Health Impacts
- Cancer Research and Treatments
- Sirtuins and Resveratrol in Medicine
- Tea Polyphenols and Effects
- Ion Channels and Receptors
- Inflammatory mediators and NSAID effects
- RNA modifications and cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Spaceflight effects on biology
- Glutathione Transferases and Polymorphisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Phytoestrogen effects and research
- Nanoplatforms for cancer theranostics
- Antioxidant Activity and Oxidative Stress
- Selenium in Biological Systems
- Genomics, phytochemicals, and oxidative stress
- PI3K/AKT/mTOR signaling in cancer
- Psychosomatic Disorders and Their Treatments
Fudan University
2025
State Key Laboratory of Medical Neurobiology
2025
Fifth Affiliated Hospital of Zhengzhou University
2022-2025
Shanghai Jiao Tong University
2025
Environmental and Occupational Health Sciences Institute
2007-2024
Rutgers, The State University of New Jersey
2013-2024
Bristol-Myers Squibb (United States)
2024
Zhengzhou University
2023
Shenyang Pharmaceutical University
2023
Zunyi Medical University
2023
Effective treatment as well prognostic biomarker for malignant esophageal squamous cell carcinoma (ESCC) is urgently needed. The present study was aimed at identifying oncogenic genes involving dysregulated intracellular Ca2+ signaling, which known to function importantly in cellular proliferation and migration. Tumors from patients with ESCC were found display elevated expression of Orai1, a store-operated entry (SOCE) channel, the high Orai1 associated poor overall recurrence-free...
Inflammation is highly associated with colon carcinogenesis. Epigenetic mechanisms could play an important role in the initiation and progression of cancer. Curcumin, a dietary phytochemical, shows promising effects suppressing colitis-associated cancer azoxymethane-dextran sulfate sodium (AOM-DSS) mice. However, potential epigenetic curcumin remain unknown. In this study, anticancer effect 18-week AOM-DSS mouse model was confirmed. We identified lists differentially expressed methylated...
In pancreatic ductal adenocarcinoma (PDAC), stromal cells and matrix proteins form a dense physical barrier that, while preventing the outward spread of tumor cells, also limits penetration drugs CD8+ T inward. Additionally, overactivated TGF-β/SMAD signaling pathway further promotes proliferation immune suppression. Therefore, crossing preserving integrity stroma, releasing intratumorally, remodeling activating system is promising drug delivery strategy. this work, type enamine N-oxides...
Abstract Purpose: Previous studies have suggested an important role of aberrant arachidonic acid metabolism, especially the cyclooxygenase (Cox) pathway, in oral carcinogenesis. However, it is unknown whether 5-lipoxygenase (5-Lox) pathway contributes to carcinogenesis, and combination inhibitors both pathways may synergistic or additive effects chemoprevention. Experimental Design: 5-Lox expression was examined 7,12-dimethylbenz[a]anthracene (DMBA)–induced hamster human cancer tissues by...
Abstract Chronic disruption of circadian rhythms by night shift work is associated with an increased breast cancer risk. However, little known about the impact on peripheral genes (CGs) and circadian‐controlled (CCGs) cancer. Hence, we assessed central clock markers (melatonin cortisol) in plasma, CGs ( PER1 , PER2 PER3 BMAL1 ) CCGs ESR1 ESR2 blood mononuclear cells (PBMCs). In day nurses n = 12), 24‐h cortisol melatonin were aligned shift‐oriented light/dark schedules. The mRNA expression...
Abstract Background Traffic-related air pollution (TRAP) has been associated with increased risk of airway inflammation in children asthma. While epigenetic changes could potentially modulate TRAP-induced inflammatory responses, few studies have assessed the temporal pattern exposure to TRAP, and Our goal was test time-lag patterns personal (measured as fractional exhaled nitric oxide, FeNO), DNA methylation promoter regions genes involved oxide synthesis among Methods We measured black...
Abstract Epigenetic dysregulation is prevalent in human cancers, affecting gene expression and metabolic patterns to meet the demands of malignant evolution abnormal epigenetic processes, resulting a protumor immune microenvironment. Tumors require steady supply methionine for maintaining flexibility, which only exogenous precursor methyl donor S‐adenosylmethionine methylation, crucial their resistance therapies survival nutrient‐deficient Thus, tumor cells upregulate Lat4 transporter...
Abstract Apart from the blood‐brain barrier (BBB), efficacy of immunotherapy for glioblastoma (GBM) is limited by presence intrinsic and adaptive immune resistance, implying that co‐delivery various immunotherapeutic agents or simultaneous regulation different cells urgently needed. Bacterial outer membrane vesicles (OMVs) offer a unique advantage in treatment GBM, owing to their multifunctional properties as carriers adjuvants ability cross BBB. However, traditional OMVs can lead toxic side...
Abstract Liver fibrosis (LF) is characterized by excessive production of reactive oxygen species (ROS), abnormal activation hepatic stellate cells (HSCs), and subsequent extracellular matrix (ECM) deposition. The complexity multiple interrelated pathways involved in this process makes it challenging for monotherapy to achieve the desired therapeutic effects. To address issue, study designs a ROS‐activated heterodimer conjugate (VTO) collaboratively alleviate LF. Additionally, biomimetic...
The identification of exogenous ligands from natural products is an alternative strategy to explore the unrevealed physiological functions orphan G-protein-coupled receptors (GPCRs). In this study, we have successfully identified and pharmacologically characterized licoisoflavone A (LIA) as a novel selective antagonist BRS-3, GPCR. Functional studies showed that pretreatment with LIA ameliorated hydrogen peroxide (H2O2)-induced cardiomyocyte injury. Furthermore, significantly restored...
// Mingzhu Fang 1, 2, 3, 4, 5 , Wei-Ren Guo 1 Youngil Park 6 Hwan-Goo Kang Helmut Zarbl Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, NJ, USA 2 School Public Health, 3 Environmental and Occupational Health Sciences Institute, 4 NIEHS Center for Exposures Disease, Cancer Institute Veterinary Drugs & Biologics Division, Animal Plant Quarantine Agency, Anyang 430-757, Republic Korea Correspondence to: Fang, e-mail: fang@eohsi.rutgers.edu Keywords:...
We consider the resource bounded quantum circuit model with circuits restricted by number of qubits they act upon and their depth. Focusing on natural universal sets gates which are familiar from classical theory, several new lower bounds for constant depth proved. The main result is that parity (and hence fanout) requires log circuits, when composed single qubit arbitrary size Toffoli gates, use only constantly many ancill\ae. Under this constraint, bound close to optimal. In case a...
// Mingzhu Fang 1, 2, 3, 4 , Pamela A. Ohman Strickland Hwan-Goo Kang 5 and Helmut Zarbl 1 School of Public Health, Rutgers, The State University New Jersey, Piscataway, NJ, USA 2 Environmental Occupational Health Sciences Institute, 3 NIEHS Center for Exposures Disease, Cancer Institute Veterinary Drugs & Biologics Division, Animal Plant Quarantine Agency, Gimcheon-si, Gyeongsangbuk-do, Republic Korea Correspondence to: Fang, email: fang@eohsi.rutgers.edu Keywords: genetic susceptibility,...
Abstract Ductal carcinoma in situ (DCIS), which accounts for one out of every five new breast cancer diagnoses, will progress to potentially lethal invasive ductal (IDC) about 50% cases. Vitamin D compounds have been shown inhibit progression IDC the MCF10DCIS model. This inhibition appears involve a reduction stem cell–like population tumors. To identify genes that are involved vitamin effects, global transcriptomic analysis was undertaken cells grown mammosphere cultures, stem–like grow...
Ferroptosis has emerged as a promising target for anticancer treatment, comprising iron-dependent lipid peroxidation and excessive accumulation of reactive oxygen species. Given that glutathione (GSH) overproduced in tumor cells antagonizes the cellular oxidation system, reduction GSH production been extensively explored to induce ferroptosis. However, reducing alone is insufficient trigger an intense storm. It highly desirable achieve systemic depletion through simultaneous consumption...
The circadian rhythm is a fundamental physiological process present in all organisms that regulates biological processes ranging from gene expression to sleep behavior. In vertebrates, controlled by molecular oscillator functions both the suprachiasmatic nucleus (SCN; central pacemaker) and individual cells comprising most peripheral tissues. More importantly, disruption of exposure light-at-night, environmental stressors and/or toxicants associated with increased risk chronic diseases...
To elucidate the molecular basis for differential susceptibilities to mammary carcinogenesis, we compared transcriptomes of normal glands from pubescent female rats resistant Copenhagen (Cop) strain with those susceptible Fischer 344 (F344), August × Irish (ACI), Buffalo/N (Buf/N), Wistar–Furth (WF) strains and F1 (Cop F344) progeny (F1). Gene expression profiles in tissue within each rat were remarkably similar, indicating that gene was determined by genetic background. We next identified...
Abstract Circadian rhythm is critical to maintaining the whole‐body metabolic homeostasis of an organism. Chronic disruption circadian by shift work important risk factor for diseases. Fibroblast growth 15/19 (FGF15/19), a key component in liver–gut axis, potently suppresses bile acid (BA) synthesis and improves insulin sensitivity. FGF15/19 emerges as novel pharmaceutical target prevention treatment The nicotinamide adenine dinucleotide (NAD + )‐dependent sirtuin 1 (SIRT1) deacetylase plays...