A5100695170- Oral Health Pathology and Treatment
- Inflammatory mediators and NSAID effects
- Multiple Sclerosis Research Studies
- Esophageal Cancer Research and Treatment
- Head and Neck Cancer Studies
- Advanced MRI Techniques and Applications
- Phytochemicals and Antioxidant Activities
- Genomics, phytochemicals, and oxidative stress
- Advanced Neuroimaging Techniques and Applications
- NF-κB Signaling Pathways
- Gastric Cancer Management and Outcomes
- Retinoids in leukemia and cellular processes
- Cancer-related molecular mechanisms research
- HIV/AIDS oral health manifestations
- Cancer-related gene regulation
- Tea Polyphenols and Effects
- Estrogen and related hormone effects
- Cardiac Imaging and Diagnostics
- Crop Yield and Soil Fertility
- Spine and Intervertebral Disc Pathology
- Eicosanoids and Hypertension Pharmacology
- Lung Cancer Research Studies
- Functional Brain Connectivity Studies
- Natural product bioactivities and synthesis
- Hops Chemistry and Applications
Capital Medical University
2013-2024
Shanxi Agricultural University
2024
Shandong Provincial Hospital
2024
Shandong University
2024
Lishui Central Hospital
2024
Jiangsu Province Hospital
2024
Nanjing University of Chinese Medicine
2024
Guangzhou Medical University
2019-2021
Guangzhou First People's Hospital
2019-2021
South China University of Technology
2019
A double‐blind intervention trial was conducted in patients with oral mucosa leukoplakia using a mixed tea product developed by the authors. Fifty‐nine patients, diagnosed established clinical and pathological criteria, were randomly divided into treated group (3 g administration topical treatment) control (placebo glycerin treatment). After 6‐month trial, size of lesion decreased 37.9% 29 increased 3.4%; whereas 10.0% 30 6.7%. At same time, incidence micronucleated exfoliated cells (5.4 per...
Abstract Purpose: Previous studies have suggested an important role of aberrant arachidonic acid metabolism, especially the cyclooxygenase (Cox) pathway, in oral carcinogenesis. However, it is unknown whether 5-lipoxygenase (5-Lox) pathway contributes to carcinogenesis, and combination inhibitors both pathways may synergistic or additive effects chemoprevention. Experimental Design: 5-Lox expression was examined 7,12-dimethylbenz[a]anthracene (DMBA)–induced hamster human cancer tissues by...
Abstract The brain connectome of multiple sclerosis (MS) has been investigated by several previous studies; however, it is still unknown how the network changes in clinically isolated syndrome (CIS), earliest stage MS, and alterations on a functional level relate to structural MS disease. Here, we topological both connectomes 41 CIS 32 patients, compared 35 healthy controls, combining diffusion tensor imaging resting-state MRI with graph analysis approaches. We found that showed deviation...
MicroRNAs (miRNAs) are small regulatory non-coding RNAs for which altered expression in cancers can serve as potential biomarkers diseases. We here investigated whether circulating miRNAs predicting post-operational recurrence of oral squamous cell carcinoma (OSCC) patients. Plasma samples from 8 Danish OSCC patients were collected before, and one year after surgical operation, well 3 healthy controls subjected to miRNA profiling by next generation sequencing. Disease did not occur the when...
// Aixian Lan 1, * , Wenjun Li Yao Liu 1 Zhaohui Xiong 2 Xinyan Zhang Shanshan Zhou 3 Olesya Palko Hao Chen Mayanga Kapita Justin R. Prigge 4 Edward E. Schmidt Xin Zheng Sun Xiaoxin Luke Department of Oral Medicine, Beijing Stomatological Hospital & School Stomatology, Capital Medical University, 100050, China Cancer Research Program, JLC-BBRI, North Carolina Central Durham, NC 27707, USA Pharmaceutical Engineering, Life Sciences, Changzhou Jiangsu 213164, Immunology and Infectious Diseases,...
Alcohol drinking is a known risk factor for oral cancer in humans. However, previous animal studies on the promoting effect of ethanol carcinogenesis were inconclusive. It necessary to develop an model with which molecular mechanism ethanol-related may be elucidated effective prevention strategies. In this study, mice first treated 4-nitroquinoline-1-oxide (4NQO, 100 μg/mL water) 8 weeks and then given water or (8%) as sole drink another 16 weeks. During experiment, 8% was well tolerated by...
Our previous studies have shown that aberrant arachidonic acid metabolism, especially the 5-lipoxygenase (5-Lox) pathway, is involved in oral carcinogenesis and can be targeted for cancer prevention. To develop potent topical agents chemoprevention, 5 known 5-Lox inhibitors from dietary synthetic sources (Zileuton, ABT-761, licofelone, curcumin, garcinol) were evaluated silico their potential efficacy. Garcinol, a polyisoprenylated benzophenone fruit rind of Garcinia spp., was found to...
Silencing of P16 through methylation and locus deletion is the most frequent early events in carcinogenesis. The aim this study to prospectively determine if a predictor for oral cancer development.Patients (n = 181) with mild or moderate epithelial dysplasia (OED) were recruited into double blind multicentre cohort. was analyzed using MethyLight assay. Progression OEDs monitored minimum 3 year follow-up period.P16 methylation-informative cases 152) enrolled prospective multicenter cohorts...
Nonspherical colloids and their ordered arrays may be more attractive in applications such as photonic crystals than spherical counterparts because of lower symmetries, although structures are difficult to achieve. In this letter, we describe the fabrication characterization colloidal constructed from nonspherical polyhedrons. We fabricated by pressing polymer crystal chips at a temperature slightly glass-transition (T(g)) these colloids. During process, microspheres were distinctively...
Colloid particles usually have charges or nanoparticles uniformly distributed over their surface. The design and preparation of unsymmetrically coated colloid been a long-standing challenge in surface science. These would remedy some limitations spherical counterparts for potential applications modeling the behaviors highly irregular colloids that are more commonly found industrial products, fields require lattices with lower symmetries high complexities, as building blocks generating...
Aberrant arachidonic acid metabolism, especially altered cyclooxygenase and 5-lipoxygenase (LOX) activities, has been associated with chronic inflammation as well carcinogenesis in human oral cavity tissues. Here, we examined the effect of Zyflamend, a product containing 10 concentrated herbal extracts, on development 7,12-dimethylbenz[alpha]anthracene (DMBA)-induced squamous cell carcinoma (SCC). A hamster cheek pouch model was used which 0.5% DMBA applied topically onto left male Syrian...
INTRODUCTION: The aim of this study was to detect the survivin, carcinoembryonic antigen (CEA) and ErbB2 in saliva, serum local tumor-exfoliated cells oral squamous cell carcinoma (OSCC) patients, for providing reliable tumor markers early detection malignant cancer. MAT ERIALS AND METHODS: serum, samples 26 OSCC patients without chemotherapy 10 non-cancer were collected Department Oral Maxillofacial Surgery, School Stomatology, Peking University. contents CEA using detected...
Ulcerative colitis is an inflammatory condition of the colon. Metformin, antidiabetic drug, can suppress cascade. We investigated effects metformin on experimental colitis. Experimental was induced in mice using dextran sulfate sodium. used three groups mice: untreated control, saline treated and treated. measured weight, disease activity index, colon length, levels cytokines, we evaluated tissue histology. found that treatment decreased mucosal damage preserved intestinal transit. also...
The North China Plain has a typical winter wheat-summer corn double-cropping pattern. effects of nutrient deficiency conditions on the root characteristics and yield summer in system were studied for four years. Long-term monotonous fertilization patterns undermine crop rotation systems are detrimental to sustainability agricultural production. To complement development rational strategies by exploring response deficiencies, an experiment was conducted randomized complete block design...
The wheat–maize rotation system in the North China Plain (NCP) has a large amount of crop straw. However, improper straw management and blind fertilization lead to nutrient imbalance accelerated loss from soil, ultimately leading deficiency affecting system. In order explore effects on yield use efficiency wheat maize, experiment was conducted randomized complete block design consisting five treatments with three replicates for each treatment: (1) potassium fertilizer appropriate nitrogen...
Background Previous studies with a small sample size have not reported metabolic changes in neuromyelitis optica (NMO). Metabolic changes, such as decreased N-acetylaspartate (NAA), are well-established patients multiple sclerosis (MS). It remains unknown whether different patterns of occur NMO and MS. Purpose To investigate the normal-appearing white matter (NAWM) NMO, compared MS healthy controls (HC), correlate these clinical disability. Material Methods We recruited 27 24 MS, HC. Each...
Abstract Objective To analyze the detection rates of colorectal cancer (CRC) and polyps by population‐based screening in Guangzhou. Methods From January 2011 to December 2015, residents aged 30‐79 were selected for CRC screening. The conducted Questionnaires and/or FOBT assess high‐risk groups, free colonoscopy examination was recommended, results evaluated detail. Results There 98 927 involving screening, 5306 identified (males 1859 females 3447), 4713 subjects underwent 1690 3023). seen 55...