A5103173313- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- MicroRNA in disease regulation
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Genetic factors in colorectal cancer
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Screening and Detection
- Diabetes Treatment and Management
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Mesenchymal stem cell research
- Cancer Genomics and Diagnostics
- Hematological disorders and diagnostics
- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- PI3K/AKT/mTOR signaling in cancer
- Multiple Myeloma Research and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer-related Molecular Pathways
- Autophagy in Disease and Therapy
- Graphene and Nanomaterials Applications
First Affiliated Hospital of Wenzhou Medical University
2012-2024
Wenzhou Medical University
2012-2024
Fujian Medical University
2012-2023
Fujian Provincial Hospital
2017-2023
National Clinical Research Center for Digestive Diseases
2020-2021
Capital Medical University
2020-2021
Beijing Friendship Hospital
2020-2021
Shanghai Clinical Research Center
2021
Creative Commons
2017
Union Hospital
2012
Multiplex assays, involving the simultaneous use of multiple circulating tumor DNA (ctDNA) markers, can improve performance liquid biopsies so that they are highly predictive cancer recurrence. We have developed a single-tube methylation-specific quantitative PCR assay (mqMSP) uses 10 different methylation markers and is capable analysis plasma samples with as little 0.05% DNA. In cohort 179 from colorectal (CRC) patients, adenoma healthy controls, sensitivity specificity mqMSP were 84.9%...
Abstract In recent years, the role of circular RNAs (circRNAs) in tumours has attracted widespread attention. Some circRNAs have been reported to play a triple-negative breast cancer (TNBC). However, rarely terms TNBC resistance. This study aimed clarify that circGFRA1 affects sensitivity cells paclitaxel (PTX) by miR-361-5p/TLR4 pathway. Compared with non-PTX-resistant cell line MDA-MB-231, expression PTX-resistant MDA-MB-231.PR was significantly increased. The small hairpin RNA-mediated...
Abstract Mitochondrial transcription termination factor 3 (MTERF3) negatively regulates mitochondrial DNA transcription. However, its role in hepatocellular carcinoma (HCC) progression remains elusive. Here, we investigate the expression and function of MTERF3 HCC. is overexpressed HCC tumor tissues higher positively correlates with poor overall survival patients. Knockdown induces dysfunction, S-G2/M cell cycle arrest apoptosis, resulting proliferation inhibition. In contrast,...
Long non-coding RNAs (lncRNAs) are crucial molecules in tumorigenesis and tumor growth various human cancers, including colorectal cancer (CRC). Studies have revealed that lncRNAs can regulate cellular processes cancers by interacting with proteins, for example RNA-binding proteins (RBPs). In this study, we recognize a novel lncRNA called LINC01413 is upregulated CRC tissues through microarray. Subsequently, confirmed an elevated level of expression was strongly correlated to...
Pitavastatin suppressed liver cancer cells in vitro and vivo He-Yi You, Wei-Jian Zhang, Xue-Meng Xie, Zhi-Hai Zheng, Heng-Liang Zhu, Fei-Zhao Jiang Department of Telescopic Surgery, The First Affiliated Hospital Wenzhou Medical University, Wenzhou, People's Republic China Abstract: classically functions as a blood cholesterol-lowering drug. Previously, it was discovered with antiglioma stem cell properties through drug screening. However, whether can be used for therapy has never been...
Abnormal expression of long noncoding RNA (lncRNA) is involved in human cancers, including colorectal cancer (CRC).However, their functional mechanism largely unknown.In this study, we explored the roles lncRNA SOCS2-AS1 modulating CRC progression.We showed that was lowly expressed tissues and cells.SOCS2-AS1 downregulation predicted a poor prognosis patients with CRC.SOCS2-AS1 overexpression significantly suppressed cell proliferation, colony formation, EdU incorporation, cell-cycle,...
Background: Acute myeloid leukemia (AML) is a highly heterogenous disease with varying clinical outcomes among patients. Epithelial-mesenchymal transition (EMT) an important mechanism underlying cancer metastasis and chemotherapy resistance. However, few EMT-based signatures have been established to predict AML prognosis treatment efficacy. Methods: By conducting comparative RNA-seq analysis, we discovered the differential expression of EMT genes between patients relapse those without...
Sphingosine kinase 1 (Sphk1) is an oncogenic that responsible for the phosphorylation of sphingosine to sphingosine-1-phosphate (S1P). Mounting evidence suggests Sphk1 serves a crucial role in proliferation and development variety human cancer cells. However, hepatocellular carcinoma (HCC) has not been fully elucidated. Therefore, expression was examined 127 formalin-fixed, paraffin-embedded HCC tissues using immunohistochemistry, its clinical implications prognostic significance were...
Bone marrow mesenchymal stem cells (BMSCs) have been considered to be an important regulator for immune function. We aim prove the function improvement of aging spleen and thymus induced by BMSCs unfold specific mechanisms. Aging animal model was established using D-galactose. The morphological changes tissues were observed hematoxylin-eosin staining transmission electron microscopy. Key cytokines in serum measured with enzyme linked immunosorbent assay. Protein mRNA levels P16, P21, PCNA...
The long non-coding RNAs (lncRNAs) have been demonstrated to play pivotal roles in a broad range of processes including tumor biology. However, the exact contributions lncRNAs hepatocellular carcinoma (HCC) remain poorly defined. In current study, we unraveled novel function AK023948 HCC. We found that was substantially upregulated tissues. Meanwhile, higher expression correlated with poor survival. Upregulation can promote HepG2 and Hep3B proliferation invasion vitro experiments....
Abstract Objectives Colorectal cancer (CRC) screening using stool samples is now in routine use where tumor DNA methylation analysis for leading markers such as NDRG4 and SDC2 an integral part of the test. However, processing reproducible efficient extraction human genomic remains a bottleneck further research into better biomarkers assays. Methods We systematically evaluated several factors involved DNA. These include: (solid homogenized samples), preparation from supernatant pellets, with...
Abstract Context: The development of cisplatin resistance is a common cause cancer recurrence in colorectal (CRC). Long non-coding RNA KCNQ1OT1 has been proven to exert its oncogenic function multiple cancers. Curcumin natural phenolic that could effectively suppress CRC. Objective: To expound the role CRC cells and whether participates reversal effect curcumin on Methods: Cell proliferation apoptosis were evaluated by CCK-8 assay flow cytometry assay, respectively. interplay between miR-497...
A cecal submucosal fecalith is extremely rare and likely to be misdiagnosed as appendicitis with an incarcerated fecalith.This review presents the case of a female patient complaining recurrent abdominal pain in right lower quadrant, similar clinical symptoms appendicitis. Physical examination revealed tenderness quadrant without rebound or muscular tension. An ultrasound found mass located abdomen. Computed tomography showed high-density shadow cavity.A was detected wall. The postoperative...
Many studies have confirmed that ileal transposition can improve type 2 diabetes mellitus (T2DM), accompanied by increased glucagon-like peptide-1 (GLP-1). We performed the experiment on diabetic rats to evaluate effects and mechanisms of glycemic metabolism.Twenty Goto-Kakizaki (GK) were randomly divided into group (IT group) sham operation (Sham group). Weight, food intake, fasting plasma glucose (FPG), insulin (F-ins), oral tolerance test (OGTT) GLP-1 determined at baseline 1, 4, 8, 16 24...
We report two rare cases of multiple myeloma (MM) with dural intracranial disease and TP53 deletion. The patients presented skull lytic lesion involvement myeloma. association between in MM deletion has not been determined. received bortezomib-based intensive induction got good response, just as that reported literature. presenting at diagnosis is associated poor outcome. Multi-drug regime containing bortezomib followed by autologous or allogeneic stem cell transportation would improve the...
Objective To investigate the clinical features of primary gastric lymphoma (PGL) combined with acute upper gastrointestinal hemorrhage, and to improve diagnosis treatment level. Methods The manifestations 2 PGL cases hemorrhage were analyzed retrospectively, related literature was reviewed. Results Two patients suffered from venosity, abdominal pain weight loss, which diagnosed by gastroscopy mucosa biopsy uncontrolled hemorrhagic shock. Vascular embolization used stop bleeding...
To explore the short-term efficacy and adverse reactions of orelabrutinib combined with high-dose methotrexate (HD-MTX) in first-line treatment elderly high-risk primary central nervous system lymphoma (PCNSL), as well survival patients.Twenty-five patients diffuse large B-cell admitted to Fujian Provincial Hospital from June 2016 2022 were enrolled this study, complete clinical data all collected retrospectively, cut-off for follow-up was December 2022. 15 had received temmozolomide HD-MTX...
Objective To evaluate effects and possible mechanisms of ileal transposition on spontaneous non-obese type 2 diabetic GK rats.Methods 20 rats were randomly divided into two groups:ileal group sham operation (n =10).We observed determined the weight change,daily average food consumption FBG (fasting blood-glucose) level before (0 weeks) 1,4,8,16 24 weeks after surgery.Glucose tolerance test (GTT) was carried out GLP-1 (glucagon-like peptide-1) concentration measured 4,8,16 surgery fasting...