A5101866811- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Analysis
- Respiratory viral infections research
- Immunotherapy and Immune Responses
- 3D Printing in Biomedical Research
- Traditional Chinese Medicine Studies
- Hydrogels: synthesis, properties, applications
- Molecular Junctions and Nanostructures
- Sphingolipid Metabolism and Signaling
- Advanced Proteomics Techniques and Applications
- Immune Response and Inflammation
- Immune cells in cancer
- Nanoplatforms for cancer theranostics
- Luminescence Properties of Advanced Materials
- Advanced Drug Delivery Systems
- Extracellular vesicles in disease
- Cholesterol and Lipid Metabolism
- Mass Spectrometry Techniques and Applications
- Hepatitis C virus research
- Genetic factors in colorectal cancer
- Mesenchymal stem cell research
- Surface Chemistry and Catalysis
- Advanced biosensing and bioanalysis techniques
- Immune Cell Function and Interaction
- Ultrasound and Cavitation Phenomena
Netherlands Metabolomics Centre
2022-2024
Leiden University
2022-2024
Hebei Medical University
2012-2024
Children's Hospital of Fudan University
2023-2024
Gansu Research Institute of Chemical Industry
2024
Wenzhou Medical University
2016-2023
Hospital of Hebei Province
2022
Henan University
2020-2021
Xuzhou Medical College
2014-2019
Lanzhou University
2019
Respiratory syncytial virus (RSV) is the main cause of acute lower respiratory tract infection (ALRI) in children worldwide. Virus-host interactions affect progression and prognosis infection. Autophagy plays important roles virus-host interactions. epithelial cells serve as front line host defense during RSV infection, However, it still unclear how they interact with RSV. In this study, we found that induced autophagy favored replication exacerbated lung pathology vivo Mechanistically,...
The importance of lipids seen in studies metabolism, cancer, the recent COVID-19 pandemic and other diseases has brought field lipidomics to forefront clinical research. Quantitative comprehensive analysis is required understand biological interactions among lipid species. However, lipidomic often challenging due various compositional structures, diverse physicochemical properties, wide dynamic range concentrations systems. To study lipidome, a hydrophilic interaction liquid...
Abstract Ribosome biogenesis (RiBi) plays a pivotal role in carcinogenesis by regulating protein translation and stress response. Here, we find that RRP15, nucleolar critical for RiBi checkpoint control, is frequently upregulated primary CRCs higher RRP15 expression positively correlated with TNM stage ( P < 0.0001) poor survival of CRC patients = 0.0011). Functionally, silencing induces ribosome stress, cell cycle arrest, apoptosis, resulting suppression proliferation metastasis....
Background Severe pneumonia due to lower respiratory tract infections (LRTIs) is a significant cause of morbidity and mortality in children. Noninfectious syndromes resembling LRTIs can complicate the diagnosis may also make targeted therapy difficult because difficulty identifying LRTI pathogens. In present study, highly sensitive metagenomic next-generation sequencing (mNGS) approach was used characterize microbiome bronchoalveolar lavage fluid (BALF) children with severe identify...
Radiotherapy is one of the effective methods for treatment breast cancer; however, controversies still exist with respect to radiotherapy patients TNBC. Here, we intend explore mechanism by which local promotes recruitment M-MDSCs in lung and increases risk metastasis TNBC tumor-bearing mice.A single dose 20 Gy X-ray was used locally irradiate primary tumor 4T1 mice. Tumor growth, number pulmonary metastatic nodules, frequency MDSCs were monitored Antibody microarray ELISA analyze cytokines...
// Xiaotian Song 1,2,* , Zhiyan Yao Jianling Yang 1,2 Zhengzheng Zhang Yuqing Deng Miao Li Cuiqing Ma Lijuan Xue Gao Wenjian Jianguo Liu 3 and Lin Wei 1 Department of Immunology, Hebei Medical University, Shijiazhuang, China 2 Key Laboratory Immune Mechanism Intervention on Serious Disease in Province, Division Infectious Diseases, Allergy Departments Internal Medicine Molecular Microbiology Saint Louis University School Medicine, St. Louis, MO, USA * These authors have contributed equally...
Alginate/CaCO3 hybrid beads with pH- and thermal-responsive drug release properties were prepared under compressed CO2 using aliphatic poly(urethane-amine)s (PU) as the component. Polyacrylic acid (PAA) was used a crystal growth additive to control structure of beads. The characterized by scanning electron microscopy, X-ray powder diffraction thermogravimetric analysis. interaction between PAA PU contributed formation alginate compact CaCO3 shell. Indomethacin behaviour found be...
Respiratory syncytial virus (RSV) is the leading cause of childhood hospitalizations. The formalin-inactivated RSV (FI-RSV) vaccine-enhanced respiratory disease (ERD) has been an obstacle to development a safe and effective killed vaccine. Agonists Toll-like receptor (TLR) have shown regulate immune responses induced by FI-RSV. Notch signaling plays critical roles during differentiation effector function phases innate adaptive responses. Cross talk between TLR pathways results in fine-tuning...
The severity of COVID-19 is linked to an imbalanced immune response. dysregulated metabolism small molecules and bioactive lipids has also been associated with disease severity. To promote understanding the biochemistry provide targets for intervention, we applied a range LC-MS platforms analyze over 100 plasma samples from patients varying detailed clinical information on inflammatory responses (>30 markers). This third publication in series, it reports results comprehensive lipidome...
The electronic structure of several arene-based monomolecular films on Au(111), with and without an alkyl linker between the aromatic unit thiol headgroup, has been investigated by photoemission inverse photoemission. While HOMO–LUMO gap in these was found to depend backbone, molecular band offset states strongly affected interfacial dipole. smallest for conjugated anthracene moiety, intermediate terphenyl, widest perfluorinated terphenyl. terphenyl-based appear be more n-type as a...
Abstract To improve the mechanical strength of natural hydrogels and to obtain a sustained drug‐delivery device, temperature‐/pH‐sensitive hydrogel beads composed calcium alginate (Ca‐alginate) poly( N ‐isopropylacrylamide) (PNIPAAm) were prepared in presence poly(sodium acrylate) (PAANa) with ultrahigh molecular weight ( M η ≥ 1.0 × 10 7 ) as strengthening agent. The influence PAANa content on properties, including stability, swelling, drug‐release behaviors, was evaluated. Scanning...
Mesenchymal stem cells (MSCs) represent promising applications in rheumatoid arthritis (RA). However, the inflammatory niche RA synovium could adversely affect MSC function. This study was designed to investigate biologic and immunologic properties of synovium-derived MSCs (SMSCs) RA, with particular focus on whether cytokines can mediate increase proliferation T cocultured SMSCs RA. Compared from eight healthy donors (HDs), 22 patients (RAp) were evaluated. The methyl thiazolyl tetrazolium...
We have investigated the chemisorption of two isomers diiodobenzene on molecular ferroelectric copolymer poly(vinylidene fluoride) with trifluoroethylene (70:30) as a function polymeric domain orientation. find that 1,4-p-diiodobenzene adsorption at 150 K strongly favors positive orientation while 1,2-o-diiodobenzene negative Both polar and nonpolar adsorbates are influenced by substrate dipole direction. Because isomer is also affected surface direction, hence chemical termination, it clear...
We have investigated the absorption and adsorption of three isomers di-iodobenzene on molecular films a zwitterionic p-benzoquinonemonoimine-type molecule which is characterized by large intrinsic dipole 10 D. Specifically, we compared reversible 1,2-di-iodobenzene, 1,3-di-iodobenzene, 1,4-di-iodobenzene (6Z)-4-(butylamino)-6-(butyliminio)-3-oxocyclohexa-1,4-dien-1-olate C6H2(···NHR)2(···O)2 where R = n-C4H9. provide unequivocal evidence that 1,3-di-iodobenzene are strongly favored at 150 K...
Abstract Protein arginine methyltransferase 3 (PRMT3) is a co-activator of liver X receptor capable selectively modulating hepatic triglyceride synthesis. Here we investigated whether pharmacological PRMT3 inhibition can diminish the steatosis extent and lower plasma lipid levels atherosclerosis susceptibility. Hereto, male hyperlipidemic low-density lipoprotein knockout mice were fed an atherogenic Western-type diet injected times per week intraperitoneally with inhibitor SGC707 or solvent...