A5113853471- Neuroscience and Neuropharmacology Research
- Cancer-related molecular mechanisms research
- Mesenchymal stem cell research
- Cholinesterase and Neurodegenerative Diseases
- Platelet Disorders and Treatments
- Traditional Chinese Medicine Analysis
- Computational Drug Discovery Methods
- RNA modifications and cancer
- Plant-based Medicinal Research
- Dementia and Cognitive Impairment Research
- Orbital Angular Momentum in Optics
- Circular RNAs in diseases
- Ocular Surface and Contact Lens
- Innovative concrete reinforcement materials
- Memory and Neural Mechanisms
- Cancer, Lipids, and Metabolism
- Plasmonic and Surface Plasmon Research
- Laser and Thermal Forming Techniques
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Mechanical stress and fatigue analysis
- Pluripotent Stem Cells Research
- Tendon Structure and Treatment
- Optical Wireless Communication Technologies
- Fibroblast Growth Factor Research
Nantong University
2025
Target (United States)
2025
Sun Yat-sen Memorial Hospital
2021-2024
Sun Yat-sen University
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Chengdu Fifth People's Hospital
2024
Chengdu University of Traditional Chinese Medicine
2024
Second Affiliated Hospital of Nanchang University
2018-2024
Nanchang University
2018-2024
Fudan University
2005-2024
Recently, circular RNAs (circRNAs) have been reported to be microRNA sponges and play essential roles in cancer development. This study aimed evaluate whether circulating circRNAs could used as diagnostic biomarkers for lung adenocarcinoma (LUAD). The Gene Expression Omnibus (GEO) dataset was investigate differentially expressed (DEcircRNAs) paired LUAD tissues adjacent nontumor tissues. expression levels of the host genes were analyzed Cancer Genome Atlas (TCGA)-LUAD dataset, prognostic...
Background and aim: Adenocarcinoma is a very common pathological subtype for lung cancer. We aimed to identify the gene signature associated with prognosis of smoking related adenocarcinoma using bioinformatics analysis. Methods: A total five expression profiles (GSE31210, GSE32863, GSE40791, GSE43458 GSE75037) have been identified from Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were analyzed GEO2R software functional pathway enrichment Furthermore, overall...
Porcine beta-defensin 2 (PBD-2) which is a member of the family antimicrobial peptides, widely expressed in pig organs with broad spectrum bactericidal activities confirmed vitro. We previously demonstrated that transgenic (TG) pigs overexpressing PBD-2 could resist infection by porcine pathogen Actinobacillus pleuropneumoniae. In this study, roles protecting against bacterial were further investigated. The biochemical indexes blood sample, body weights, histological morphologies and weights...
IMMH-010 is an ester prodrug of YPD-29B, a potent programmed cell death ligand 1 (PD-L1) inhibitor. The metabolism was investigated and compared in various species. Four metabolites were identified, the major metabolite parent compound, which mainly catalyzed by carboxylesterase (CES1). We observed plasma rapidly metabolized to YPD-29B rat mouse plasma, whereas it remained stable human monkey plasma. In liver S9 fractions human, monkey, dog, rat, quickly transformed with no obvious...
Summary After exposure to an agonist, platelets are activated and become aggregated. They also shed membrane microparticles that participate in the pathogenesis of thrombosis, hyper-coagulation inflammation. However, microvesiculation can potentially disrupt integrity platelet aggregation by shedding receptors phosphatidylserine critical for forming stabilising a clot. We tested hypothesis adhesion functions different subsets at time haemostasis real-time monitoring agonist-induced...
Cognitive dysfunction constitutes an essential component in schizophrenia for its early presence the pathophysiology of disease and close relatedness to life quality patients. To develop effective treatment cognitive deficits, it is important understand their neurobiological causes identify potential therapeutic targets. In this study, adopting repeated MK-801 as animal model schizophrenia, we investigated whether antipsychotic drugs, olanzapine haloperidol, can reverse MK-801-induced...
As for traditional Chinese medicine (TCM) prescription, what puzzled researchers most was how to select proper chemical markers represent the whole pharmacological action system. In this paper, an integrated metabolomic method presented a systematic discovery of potential active components in Fangji Huangqi Tang (FHT), well-known TCM prescription nephrotic syndrome treatment, based on "correlations between and metabolic profiles." Firstly, metabolomics study carried out representative...
Multiple lines of evidence have demonstrated that increased expression phospholipid scramblase 1 (PLSCR1) is involved in the differentiation acute myeloid leukemia (AML) cells by several differentiation-inducing agents including ATRA and phorbol 12-myristate 13-acetate. However, none these can achieve nonhomogenous subcellular distribution PLSCR1. We wogonoside possesses anti-leukemic effects AML cell promoting PLSCR1 trafficking into nucleus. Here we report promotes enhances its nuclear...
Objective: The mechanism of CD4+ T-cell dysfunction in systemic lupus erythematosus (SLE) has not been fully understood. Increasing evidence show that long noncoding RNAs (lncRNAs) can regulate immune responses and take part some autoimmune diseases, while little is known about the lncRNA expression function T SLE. Here, we aimed to detect profile lncRNAs cells explore how lincRNA00892 involved pathogenesis Methods: profiles mRNAs from SLE patients healthy controls were detected by...
Background: In previous years, immunotoxins have been shown to be a greatly promising therapeutic tool for brain malignancies, such as gliomas. Human mesenchymal stem cells (hMSCs) exhibit tropism tumor tissue. However, the effect of bispecific in malignant gliomas is still unknown. The aim this study was investigate function human Materials and methods: present study, immunotoxin VEGF 165 -ephrin A1-PE38KDEL established using deoxyribonucleic acid shuffling cloning techniques. delivered by...
Abstract Defining the immune physiology of culture-adapted mesenchymal stromal cells (MSCs) derived from distinct tissue compartments informs their potential utility as pharmaceuticals. Here, we have investigated comparative plasticity MSCs and hepatic stellate (HeSCs) isolated human murine bone marrow (BM) liver, respectively. Although both BM–MSCs HeSCs share phenotype overall molecular genetic responses to inflammatory cues, differ in a meaningful manner. We show that culture–adapted...
The combustion behavior and mechanism of Ti14 titanium alloy are studied by promoted ignition tests at different oxygen pressures in this paper. burning velocity increases higher also with longer times instead a constant the same pressure. Cu atoms found enriched two zones-i.e., heat affected zone melting during process-which can prevent diffusion process atoms. Ti-Cr-V alloys is basically controlled characteristics phase structures chemical reactions.
Background: Glucuronidation is an essential metabolic pathway for a variety of drugs. IMM-H004 novel neuroprotective agent against ischemic stroke, and its glucuronide metabolite IMM-H004G exhibits similar pharmacological activity. Despite possessing higher molecular weight polarity, brain exposure much than that IMM-H004. This study aimed to investigate the metabolism transport mechanisms IMM-H004G. Methods: First, possibility glucuronidation in was evaluated several human cell lines rat...
Bicyclol is a hepatoprotective agent widely used for treating chronic hepatitis and drug-induced liver injuries in clinics. The purpose of the study was to elucidate contribution CYP450 enzymes metabolism bicyclol using relative activity factor approach. After incubation with human microsomes recombinant enzymes, calculated CYP3A4 2C19 85.6–90.3% 9.2–9.7%, respectively. interrupted presence selective inhibitors. These findings help predict or avoid metabolic drug–drug interactions toxicity...