A5061128410- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Barrier Structure and Function Studies
- Gout, Hyperuricemia, Uric Acid
- Helicobacter pylori-related gastroenterology studies
- MicroRNA in disease regulation
- Immune Response and Inflammation
- Neurological Disease Mechanisms and Treatments
- Cardiac Health and Mental Health
- Cardiac Ischemia and Reperfusion
- Cancer-related gene regulation
- Retinoids in leukemia and cellular processes
- Oral health in cancer treatment
- Muscle and Compartmental Disorders
- Cardiac Imaging and Diagnostics
- Anesthesia and Pain Management
- Parathyroid Disorders and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Cells and Metastasis
- Mycobacterium research and diagnosis
- Peroxisome Proliferator-Activated Receptors
- Signaling Pathways in Disease
- Traditional Chinese Medicine Analysis
- Colorectal Cancer Treatments and Studies
- Circular RNAs in diseases
Jiangsu Province Hospital
2017-2024
Nanjing University of Chinese Medicine
2017-2024
University of Chicago
2013-2024
Chinese Academy of Forestry
2022
State Forestry and Grassland Administration
2022
Research Institute of Forestry
2022
Peking Union Medical College Hospital
2014-2021
China Pharmaceutical University
2016-2021
The Fourth People's Hospital of Ningxia Hui Autonomous Region
2021
Minzu University of China
2021
Intimal hyperplasia, the key event of arterial restenosis, is a result vascular smooth muscle cell (VSMC) proliferation and migration. Previous studies have demonstrated that total Panax notoginseng saponin (TPNS) represses intimal hyperplasia inhibits VSMCs following balloon injury. However, underlying roles TPNS in remain unclear. In this study, we first found inhibited reversed reduced m6A quantity catheter-injured rat carotid artery. Then, measured expression profiles "writers" (i.e.,...
Ferroptosis is associated with the pathology of myocardial ischemia/reperfusion (MI/R) injury following infarction, which a leading cause death worldwide. Although long noncoding RNAs (lncRNAs) are known to regulate gene expression, their roles in MI/R-induced ferroptosis remain unclear. In this study, we explored lncRNA expression profiles rat model MI/R and found that novel lncRNA, lncAABR07025387.1, was highly expressed MI/R-injured tissues hypoxia/reoxygenation (H/R)-challenged cells....
Ferroptosis is a form of cell death induced by excess iron and accumulation reactive oxygen species in cells. Recently, ferroptosis has been reported to be associated with cancer ischemia/reperfusion (I/R) injury multiple organs. However, the regulatory effects underlying mechanisms myocardial I/R are not well-understood. The role miR-135b-3p as an oncogene that accelerates tumor development confirmed; however, its fully understood. In this study, we established vivo rat model vitro...
Abstract The proto-oncogene MYC encodes a nuclear transcription factor that has an important role in variety of cellular processes, such as cell cycle progression, proliferation, metabolism, adhesion, apoptosis, and therapeutic resistance. amplification is consistently observed aggressive forms several solid malignancies correlates with poor prognosis distant metastases. While the tumorigenic effects patients head neck squamous carcinoma (HNSCC) are well known, molecular mechanisms by which...
Lung cancer represents one of the most frequent solid tumors. Adenocarcinoma is a common type tumor and significant threat to individual health globally. MicroRNAs (miRNAs) are recognized as critical governors gene expression during carcinogenesis, while their effects on lung occurrence development required for further investigation. Herein, functional role miR-210-3p its regulation mechanism were characterized in cancer.A total 50 pairs tumor-free tissues surgically resected from patients....
Despite recent advancements, the 5 year survival of head and neck squamous cell carcinoma (HNSCC) hovers at 60%. DCLK1 has been shown to regulate epithelial-to-mesenchymal transition as well serving a cancer stem marker in colon, pancreatic renal cancer. Although it was reported that is associated with poor prognosis oropharyngeal cancers, very little known about molecular characterization HNSCC. In this study, we performed comprehensive transcriptome-based computational analysis on hundreds...
Abstract Objectives Previous studies have shown that there may be a positive correlation between serum uric acid levels and hyperthyroidism. However, the relationship thyroid function in healthy people is unclear. This study analyzed impaired hormone sensitivity levels, presented them quantitative form. Research design methods cross-sectional of 4460 adults (male: 2300; female: 2160) who participated National Health Nutrition Examination Survey (NHANES) from 2007 to 2010. Parameters...
We previously reported that serum N1-methylnicotinamide (me-Nam), an indicator of nicotinamide N-methyltransferase activity, is associated with obesity and diabetes mellitus in Chinese patients. However, whether plays a role human coronary artery disease (CAD) remains to be elucidated. aim investigate the associations me-Nam CAD patients.Serum me-NAM was measured by liquid chromatography-mass spectrometry patients (n=230) or without (n=103) as defined angiography. The severity expressed...
Multiple lines of evidence have demonstrated that increased expression phospholipid scramblase 1 (PLSCR1) is involved in the differentiation acute myeloid leukemia (AML) cells by several differentiation-inducing agents including ATRA and phorbol 12-myristate 13-acetate. However, none these can achieve nonhomogenous subcellular distribution PLSCR1. We wogonoside possesses anti-leukemic effects AML cell promoting PLSCR1 trafficking into nucleus. Here we report promotes enhances its nuclear...
Soluble Klotho (S-Klotho) is an anti-aging protein mainly secreted by the kidneys. Hyperuricemia prevalent among middle-aged and elderly individuals, which affects development of various chronic diseases. However, there are relatively few studies investigating association between plasma S-Klotho levels hyperuricemia in individuals. This study sought to clarify relationship risk people.During 2007-2016, a total 50,588 people participated National Health Nutrition Examination Survey. Finally,...
Oroxylin A (OA), a naturally occurring monoflavonoid isolated from Scutellariae radix, has previously been reported to inhibit the proliferation of several cancer cell lines. CD4+CD25+Foxp3+ regulatory T cells (Tregs) play an important role in maintenance immunologic self-tolerance. Tregs also increase and take part suppressing antitumor immune responses. Here, we explored how OA affected lung environment involved underlying mechanism. It is found that reversed generation induced by H460...
At present, due to the limitations of drug therapy targets for atherosclerosis, some patients fail achieve satisfactory efficacy. Cholesterol efflux dysfunction and endothelial cell inflammation are considered be important factors in development atherosclerosis. Peroxisome proliferator-activated receptor gamma (PPARγ), a promising therapeutic target plays dual role regulating cholesterol inflammation. However, use PPARγ agonist clinical practice is greatly limited as it could lead water...
Tumor necrosis factor alpha (TNFα) is a complicated cytokine which involved in proliferation and differentiation of acute myelogenous leukemia (AML) cells through poorly understood mechanism. Mechanistic studies indicate that TNFα induced binding PI3K subunit p85α to N-terminal truncated nuclear receptor RXRα (tRXRα) proteins, activated AKT. The PI3K/AKT pathway negatively regulated AML the upregulation c-Myc. In addition, also activation κB (NF-κB), transcription was shown promote cell...
BackgroundIn recent years, baroreflex activation therapy (BAT) has been utilized to treat heart failure with reduced ejection fraction (HFrEF). However, the supporting literature on its efficacy and safety is still limited. This investigation elucidates effects of BAT in HFrEF patients provide a reference for future clinical applications.MethodsThis follows Preferred Reporting Items Systematic Reviews Meta-Analysis (PRISMA) 2020 guidelines. Relevant investigations use were searched selected...
Recently, anticancer peptides (ACPs) have emerged as unique and promising therapeutic agents for cancer treatment compared with antibody small molecule drugs. In addition to experimental methods of ACPs discovery, it is also necessary develop accurate machine learning models ACP prediction. this study, features were extracted from the three-dimensional (3D) structure model, most previous computational models, which are based on sequence information. order more potency, selectivity less...
BackgroundAt present, the pathogenesis of atherosclerosis has not been fully elucidated, and diagnosis treatment face great challenges. Cuproptosis is a novel cell death pattern that might be involved in development atherosclerosis. However, no research reported correlation between cuproptosis atherosclerosis.MethodsThe differential cuproptosis-related genes (CRGs) group control (A-CRGs) were discovered via expression analysis. The analysis, PPI network GO, KEGG GSEA analysis performed to...
Abstract Acute myeloid leukaemia ( AML ) comprises a range of disparate genetic subtypes, involving complex gene mutations and specific molecular alterations. Post‐translational modifications proteins influence their translocation, stability, aggregation even leading disease progression. Therapies that target to post‐translational modification in cancer cells represent novel treatment strategy. Non‐homogenous subcellular distribution PLSCR 1 is involved the primary cell differentiation....
In order to create a hemodynamic environment that can simulate the physiological condition of arteries, an in vitro experiment apparatus was designed whose key modules were compliance chamber and after-load. These two developed based on theories hemodynamics. Both normal shear stress which endothelial cells are exposed be controlled with these modules, thus facilitating research subjected stresses.