A5021701420- Heart Rate Variability and Autonomic Control
- Cardiac Health and Mental Health
- Traditional Chinese Medicine Analysis
- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Neurofibromatosis and Schwannoma Cases
- Cardiomyopathy and Myosin Studies
- Cholesterol and Lipid Metabolism
- Medicinal Plant Pharmacodynamics Research
- Ubiquitin and proteasome pathways
- Tryptophan and brain disorders
- Viral Infections and Immunology Research
- Peptidase Inhibition and Analysis
- Vagus Nerve Stimulation Research
- Lipid metabolism and disorders
- Natural Compounds in Disease Treatment
- Mitochondrial Function and Pathology
- Cardiovascular Effects of Exercise
- Heart Failure Treatment and Management
- Redox biology and oxidative stress
- MicroRNA in disease regulation
- RNA modifications and cancer
- Blood Pressure and Hypertension Studies
- Macrophage Migration Inhibitory Factor
- Ginseng Biological Effects and Applications
Nanjing University of Chinese Medicine
2022-2024
Jiangsu Province Hospital
2022-2024
Tsinghua University
2024
At present, due to the limitations of drug therapy targets for atherosclerosis, some patients fail achieve satisfactory efficacy. Cholesterol efflux dysfunction and endothelial cell inflammation are considered be important factors in development atherosclerosis. Peroxisome proliferator-activated receptor gamma (PPARγ), a promising therapeutic target plays dual role regulating cholesterol inflammation. However, use PPARγ agonist clinical practice is greatly limited as it could lead water...
The pathogenesis of myocardial infarction complicating depression is still not fully understood. Bioinformatics an effective method to study the shared multiple diseases and has important application value in depression.The differentially expressed genes (DEGs) between control group (M-DEGs), (D-DEGs) were identified training set. M-DEGs D-DEGs intersected obtain DEGs by two (S-DEGs). GO, KEGG, GSEA correlation analysis conducted analyze function DEGs. biological differences analyzed GSVA...
BackgroundAt present, the pathogenesis of atherosclerosis has not been fully elucidated, and diagnosis treatment face great challenges. Cuproptosis is a novel cell death pattern that might be involved in development atherosclerosis. However, no research reported correlation between cuproptosis atherosclerosis.MethodsThe differential cuproptosis-related genes (CRGs) group control (A-CRGs) were discovered via expression analysis. The analysis, PPI network GO, KEGG GSEA analysis performed to...
BackgroundIn recent years, baroreflex activation therapy (BAT) has been utilized to treat heart failure with reduced ejection fraction (HFrEF). However, the supporting literature on its efficacy and safety is still limited. This investigation elucidates effects of BAT in HFrEF patients provide a reference for future clinical applications.MethodsThis follows Preferred Reporting Items Systematic Reviews Meta-Analysis (PRISMA) 2020 guidelines. Relevant investigations use were searched selected...
Coronary microembolism (CME) is commonly seen in the peri-procedural period of Percutaneous Intervention (PCI), where local platelet activation and endothelial cell inflammation crosstalk may lead to micro thrombus erosion rupture, with serious consequences. Qihuang Zhuyu Formula (QHZYF) a Chinese herbal compound high efficacy against coronary artery disease, but its antiplatelet mechanism unclear.
Neurofibromatosis type 1 (NF1) is a prevalent autosomal dominant disorder caused by mutations in the NF1 gene, leading to multisystem disorders. Given critical role of cysteine residues protein stability and function, we aimed identify key affecting that significantly contribute neurofibromatosis pathology. To most gene pathology neurofibromatosis, employed sophisticated computational pipeline specifically designed detect significant gene. Our approach involved an exhaustive search databases...
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Cuproptosis is a recently reported new mode of programmed cell death which might be potential co-pathogenesis three kinds primary cardiomyopathy. However, no investigation has clear relevance between cardiomyopathy and cuproptosis. In this study, the differential cuproptosis-related genes (CRGs) shared by were identified in training sets. As result, four CRGs acquired they mainly related to biological processes such as immuno-inflammatory response through analysis, correlation GSEA, GSVA...