A5079274064- Magnetic properties of thin films
- Magnetic and transport properties of perovskites and related materials
- Cardiac Health and Mental Health
- Cancer-related gene regulation
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Cardiac Imaging and Diagnostics
- Sesame and Sesamin Research
- Conducting polymers and applications
- Copper-based nanomaterials and applications
- Chalcogenide Semiconductor Thin Films
- Quantum Dots Synthesis And Properties
- Ginger and Zingiberaceae research
- RNA modifications and cancer
- Bone and Dental Protein Studies
- dental development and anomalies
- Multiferroics and related materials
- Advanced Sensor and Energy Harvesting Materials
- Orthodontics and Dentofacial Orthopedics
- Wood and Agarwood Research
- Epigenetics and DNA Methylation
- Protein Kinase Regulation and GTPase Signaling
- Chromatography in Natural Products
- Muscle Physiology and Disorders
- Advanced biosensing and bioanalysis techniques
Nanjing Agricultural University
2021-2025
Shaanxi University of Science and Technology
2019-2024
Nanjing University of Chinese Medicine
2021-2024
Jiangsu Province Hospital
2021-2024
Heilongjiang Provincial Hospital
2024
Chang'an University
2024
North China Electric Power University
2021-2023
University of Science and Technology Beijing
2019-2023
University of Southern California
2021-2023
Harbin Medical University
2013-2022
Abstract Background Agarwood is an expensive resinous heartwood derived from Aquilaria plants that widely used in traditional medicines, incense and perfume. Only wounded trees can produce agarwood, the huge demand for agarwood products has led all spp. being endangered listed Appendix II of CITES ( http://www.cites.org ). The major components are sesquiterpenes phenylethyl chromones. Owing to a lack genomic information, molecular basis wound-induced biosynthesis formation remains unknown....
Manipulating spin polarization orientation is challenging but crucial for field-free spintronic devices. Although such manipulation has been demonstrated in a limited number of antiferromagnetic metal-based systems, the inevitable shunting effects from metallic layer can reduce overall device efficiency. In this study, we propose an insulator-based heterostructure NiO/Ta/Pt/Co/Pt control without any effect layer. We show that zero-field magnetization switching be realized and related to...
Phagocytic macrophages and dendritic cells are desirable targets for potential RNAi (RNA interference) therapeutics because they often mediate pathogenic inflammation autoimmune responses. We recently engineered a complex 5 component glucan-based encapsulation system siRNA (small interfering RNA) delivery to phagocytes. In experiments designed simplify this original formulation, we discovered that the amphipathic peptide Endo-Porter forms stable nanocomplexes with can potent gene silencing...
Several mammalian proteins involved in chromatin and DNA modification contain CXXC zinc finger domains. We compared the structure function of domains methyltransferase Dnmt1 methylcytosine dioxygenase Tet1. Sequence alignment showed that both have a very similar framework but differ central tip region. Based on known MLL1 domain we developed homology models designed expression constructs for isolated Tet1 accordingly. show has no binding activity is dispensable catalytic vivo. In contrast,...
Wound management is a major challenge worldwide, placing huge financial burden on the government of every nation. dressings that can protect wounds, accelerate healing, prevent infection, and avoid secondary damage continue to be focus research in health care clinical communities. Herein, novel zwitterionic polymer (LST) hydrogel incorporated with [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide (SBMA), mussel-inspired N-[tris(hydroxymethyl)methyl] acrylamide (THMA),...
Conventional hemostatic agents face challenges in achieving rapid hemostasis and effective tissue repair due to limited scenarios, suboptimal efficacy, inadequate adhesion wet tissues. Drawing inspiration from nature-sourced materials, a gelatin-based adhesive hydrogel (AOT) is designed, easily prepared quick form, driven by Schiff base multiple hydrogen bonds for applications arterial liver bleeding models. AOT exhibits exceptional tissues (48.67 ± 0.16 kPa) displays superior properties...
Four lanthanide-based metal–organic frameworks, [Emim][Ln1.5(2,5-tdc)2]Cl1.5−xBrx (Ln = Nd 1, Eu 2) and [Emim][Ln(2,5-tdc)2] 3, 4) (2,5-tdc thiophene-2,5-dicarboxylate, Emim 1-methyl-3-ethylimidazolium), were synthesized under ionothermal conditions. Compounds 1 2 crystallize in the polar space groupP21212, while 3 4 central symmetry groupP21/c. Luminescence studies revealed a significantly higher quantum yield of than that 2, with similar lifetimes. It is clear coordination halide ions has...
Abstract Clinical actigraphy devices provide adequate estimates of some sleep measures across large groups. In practice, providers are asked to apply clinical or consumer wearable data individual patient assessments. Inter‐individual variability in device performance will impact such patient‐specific interpretation. We assessed two devices, and consumer, determine the magnitude predictors this individual‐level variability. One hundred patients (55 [53.9%] female; 56.4 [±16.3] years old)...
This work demonstrated a straightforward strategy to fabricate ultralong interconnected polypyrrole (PPy-GS) nanowires with gemini surfactant (GS) as soft template and dopant. Pure PPy particles nanowire doped CTAB (PPy-CTAB) were prepared for comparison. The results showed that the electrochemical performances, conductivity, morphology of PPy-GS could be significantly changed by changing concentration GS in aqueous phase owing different self-assembly behaviors. When molar ratio pyrrole,...
Flexible electronic devices have shown increasingly promising value facilitating our daily lives. However, flexible spintronic remain in their infancy. Here, this research demonstrates a type of nonvolatile, low power dissipation, and programmable spin logic device, which is based on the spin-orbit torque polyimide (PI)/Ta/Pt/Co/Pt heterostructures fabricated via capillary-assisted electrochemical delamination. The magnetization switching ratio to be about 50% for device does not change...
Tet proteins are emerging as major epigenetic modulators of cell fate and plasticity. However, little is known about how targeted to selected genomic loci in distinct biological contexts. Previously, a CXXC-type zinc finger domain Tet1 was shown bind CpG-rich DNA sequences. Interestingly, human mouse the Tet2 Tet3 genes adjacent Cxxc4 Cxxc10-1, respectively. The CXXC domains encoded by these loci, together with those Cxxc5, identify homology group within family. Here we provide evidence for...
Laccases catalyze a variety of electron-rich substrates by reducing O2 to H2O, with playing vital role as the final electron acceptor in reaction process. In present study, laccase gene, lach5, was identified from Bacillus atrophaeus through sequence-based screening. LacH5 engineered for modification fusion expression and promoter replacement. Results showed that purified enzyme exhibited strong oxidative activity towards 2,2'-azinobis(3-ehtylbenzothiazolin-6-sulfnic acid) ammonium salt...
Myoblast differentiation into mature myotubes is a critical step in the development and repair of human skeletal muscle. Here we show that small interfering RNA (siRNA)-based silencing Ste20-like mitogen-activated protein 4 kinase (Map4k4) C2C12 myoblasts markedly enhances expression myogenic genes, myoblast fusion, myotube diameter. In contrast, adenovirus-mediated native Map4k4 cells attenuates each these processes, indicating negative regulator hypertrophy. Expression kinase-inactive...
Abstract Increasing numbers of SARS-CoV-2-positive (SARS-CoV-2 pos ) subjects are detected at silent SARS-CoV-2 infection stage (SSIS). Yet, SSIS represents a poorly examined time-window wherein unknown immunity patterns may contribute to the fate determination towards persistently asymptomatic or overt disease. Here, we retrieved blood samples from 19 and 12 presymptomatic subjects, 47 age/gender-matched patients with mild moderate COVID-19 27 normal interrogated them combined assays...
In the present study, a feruloyl esterase DLFae4 identified in our previous research was modified by error-prone PCR and site-directed saturation mutation to enhance catalytic efficiency acyltransferase activity further. Five mutants with 6.9-118.9% enhanced toward methyl ferulate (MFA) were characterized under optimum conditions. Double variant DLFae4-m5 exhibited highest hydrolytic (270.97 U/mg), Km value decreased 83.91%, Kcat/Km increased 6.08-fold MFA. Molecular docking indicated that...