Wound management is a major challenge worldwide, placing huge financial burden on the government of every nation. dressings that can protect wounds, accelerate healing, prevent infection, and avoid secondary damage continue to be focus research in health care clinical communities. Herein, novel zwitterionic polymer (LST) hydrogel incorporated with [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide (SBMA), mussel-inspired N-[tris(hydroxymethyl)methyl] acrylamide (THMA),...

Conventional hemostatic agents face challenges in achieving rapid hemostasis and effective tissue repair due to limited scenarios, suboptimal efficacy, inadequate adhesion wet tissues. Drawing inspiration from nature-sourced materials, a gelatin-based adhesive hydrogel (AOT) is designed, easily prepared quick form, driven by Schiff base multiple hydrogen bonds for applications arterial liver bleeding models. AOT exhibits exceptional tissues (48.67 ± 0.16 kPa) displays superior properties...

Abstract Fibrin glue has been widely used as a surgical sealing and hemostatic agent. Its application is restricted due to poor tissue adhesion low mechanical strength. To develop better sealant agent, this study prepared the injectable hydrogels by chemically cross‐linking gelatin (G) with or without hyaluronic acid (HA) in situ at mild condition. The rheological analysis, Fourier transform infrared spectroscopy, swelling, proteolytic degradation, biocompatibility, sealing, ability of were...

Somatic PIK3CA mutations may relate to pathogenesis of isolated macrodactyly. We set up test the association between with macrodactyly in order establish a more accurate and molecular mechanism-based diagnosis classification. DNA extracted from affected tissues 12 individuals was tested for mutation using targeted Sanger sequencing. Ten patients had foot two hand. Nine were found carry low-level, mosaic mutation. The identified, p.His1047Arg, p.His1047Leu, p.Glu545Lys, p.Glu542Lys, are...

PurposeMacrodactyly is a rare, nonhereditary congenital deformity. Digital enlargement in macrodactyly involves all tissue types and presents alone or as part of deformity syndromes. Macrodactyly treatment largely depends on surgeons' experience knowledge. Because there paucity large cohort studies the literature, our goal was to retrospectively analyze cases order define better system for diagnosis, classification, prognosis.MethodsMedical records 90 Chinese patients, including demographic...

To describe the modified mobilization surgery technique that uses a free vascularized fascia lata graft as interposition graft, and to evaluate outcome of this procedure in treating congenital radioulnar synostosis (CRUS).Eleven patients (eight boys three girls with an average age 6.0 years) were treated using between 2012 2017 our institution. Five bilateral cases (four left forearms one right forearm treated), six unilateral (three forearms) included. All 11 followed-up for 2.2 years...

Abstract The uniform dispersion of hexagonal boron nitride (h‐BN) in a waterborne polymer matrix remains challenge preparing h‐BN/polymer composite coating. Here, cationic Gemini surfactant (GS‐16) is used as and intercalator to exfoliate functionalize bulk h‐BN for GS‐16‐functionalized nanosheets (G‐BNNS). For comparison, the conventional hexadecyl trimethyl ammonium bromide (CTAB) with same structural unit was utilized prepare CTAB‐functionalized BNNS (C‐BNNS). Compared C‐BNNS, G‐BNNS...

Objectives The present study describes a novel technique for revitalising allogenic intrasynovial tendons by combining cell-based therapy and mechanical stimulation in an ex vivo canine model. Methods Specifically, flexor digitorum profundus were used this divided into the following groups: (1) untreated, unprocessed normal tendon; (2) decellularised (3) bone marrow stromal cell (BMSC)-seeded (4) BMSC-seeded cyclically stretched tendon. Lateral slits introduced on tendon to facilitate...

ABSTRACT The purpose of this study was to investigate the biomechanical properties modified repair techniques for flexor tendon reconstruction and effects surface modification using carbodiimide‐derivatized synovial fluid plus gelatin (cd‐SF‐G), compared traditional techniques. second fifth digits from 16 canine forepaws were randomly divided into 4 groups: (1) graft repairs (TGR group) including distal Bunnell proximal Pulvertaft weave repair; (2) (MGR bony attachment step‐cut (3) group TGR...

Zwitterionic hydrogels, with their unique antibacterial and tissue-adhesive nature, show great potential in the fields of wearable sensors, healthcare monitoring, e-skins. However, it remains a huge challenge to integrate high elasticity low hysteresis such hydrogel via simple methods. Herein, novel zwitterionic sensor was fabricated by one-pot method using copolymerization [2-(Methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide (SBMA), N-[Tris (hydroxymethyl)methyl]...

The magnetic properties and overlayer-induced reorientation of magnetization in thin ferromagnetic films are investigated within the single-band Hubbard model. A generalization modified alloy analogy (MAA) is applied to deal with modifications due reduced translational symmetry. Within MAA actual type determined self-consistently. allows, particular, investigation quasiparticle lifetime effects paramagnetic as well phase. layer magnetizations calculated a function temperature film thickness...

Objective To present the clinical result of a procedure using pedicle posterior interosseous perforator adipofascial flaps for treatment congenital proximal radioulnar synostosis (CPRUS). Methods Eight forearms (from eight patients) with CPRUS were treated by operation during December 2013 to January 2018 at Beijing Jishuitan Hospital. The average age children are seven years old (range: five twelve old). There six boys and two girls. Seven classified as Cleary type Ⅲ, one forearm was...

Objective To evaluate the treatment effects of coronal fracture hamate with fixation titanium miniplate crossing carpometacarpal joint. Methods From December 2011 to June 2015, 17 patients suffered from were treated joint. The all males, aged 18 43 years, average (28.9±7.0) years. According classification Ebraheim’s body fracture, 2 cases type A, 5 B, 10 C. All fractures exposed by dorsal approach. After reduction, fixed joint dorsally. disabilities arm, shoulder and hand (DASH),...

Objective: To systematically investigate PIK3CA mutations in isolated macrodactyly. Methods: Overgrowth tissues from 12 macrodactyly patients who were treated at Department of Hand Surgery, Beijing Jishuitan Hospital May to August 2017 collected during operation.There 6 male and female with average age 4.5 years. DNA was tested for mutation using a targeted Sanger sequencing method.Samples negative result next generation sequencing(NGS)panel targeting 47 cancer hotspot genes including...

Objective Congenital constriction ring syndrome (CCRS) is among the most common congenital deformities of hand.However,few techniques have been described for correction this anomaly,and none these could provide complete deformity.We describe our two-stage surgical strategy and report treatment outcomes.Methods From January 2007 to 2012,50 children (195 digits) with CCRS in hand underwent surgery.The follow-up period averaged 23.9 months.At stage I,following excision dorsal fibrotic ring,the...

Objective To evaluate the results of simple curettage without bone grafting in treatment enchondroma hand. Methods Between July 2004 and December 2009, 13 patients with hand were treated grafting. Postoperative evaluations included maximum diameter at lesion site, active range motion X-ray changes involved fingers.Results All follow-up for 8 to 37 months, an average 21.3 months. New formation remodeling lesions observed all patients. The mean site decreased significantly. There was no...