A5074276556- Child and Adolescent Psychosocial and Emotional Development
- Child and Adolescent Health
- Attention Deficit Hyperactivity Disorder
- interferon and immune responses
- Family and Disability Support Research
- Lysosomal Storage Disorders Research
- Autism Spectrum Disorder Research
- Adolescent and Pediatric Healthcare
- Infant Development and Preterm Care
- Autophagy in Disease and Therapy
- Immune Response and Inflammation
- Child Nutrition and Feeding Issues
- Cytokine Signaling Pathways and Interactions
- Glycogen Storage Diseases and Myoclonus
- Systemic Lupus Erythematosus Research
- Infant Health and Development
- Child Abuse and Trauma
- Healthcare Systems and Technology
- Maternal Mental Health During Pregnancy and Postpartum
- Psychosomatic Disorders and Their Treatments
- Inflammasome and immune disorders
- Bone Metabolism and Diseases
- Behavioral and Psychological Studies
- Immune Cell Function and Interaction
- Pediatric health and respiratory diseases
University of North Carolina at Chapel Hill
2021-2024
Johns Hopkins University
2017-2023
Johns Hopkins Medicine
2023
Nationwide Children's Hospital
2008-2020
Weatherford College
2020
Creative Commons
2020
The Ohio State University
2010-2020
University of Massachusetts Chan Medical School
2011-2020
Mission Children's Hospital
2020
University of Washington
2019-2020
Children need to develop a variety of skill sets optimize their development and manage toxic stress. Research demonstrates that developmentally appropriate play with parents peers is singular opportunity promote the social-emotional, cognitive, language, self-regulation skills build executive function prosocial brain. Furthermore, supports formation safe, stable, nurturing relationships all caregivers children thrive. Play not frivolous: it enhances brain structure promotes (ie, process...
Autophagy, an intracellular system for delivering portions of cytoplasm and damaged organelles to lysosomes degradation/recycling, plays a role in many physiological processes is disturbed diseases. We recently provided evidence the autophagy Pompe disease, lysosomal storage disorder which acid alphaglucosidase, enzyme involved breakdown glycogen, deficient or absent. Clinically disease manifests as cardiac skeletal muscle myopathy. The current replacement therapy (ERT) clears glycogen...
Although many efforts have been made to improve the quality of care delivered children with attention-deficit/hyperactivity disorder (ADHD) in community-based pediatric settings, little is known about typical ADHD these settings other than rates garnered through pediatrician self-report.Rates evidence-based and sources variability (practice-level, pediatrician-level, patient-level) were determined by chart reviews a random sample 1594 patient charts across 188 pediatricians at 50 different...
Innate immune pattern recognition receptors sense nucleic acids from microbes and orchestrate cytokine production to resolve infection. Inappropriate of host also results in autoimmune disease. In this study, we use a model inflammation resulting accrual self DNA (DNase II(-/-) type I IFN receptor [Ifnar](-/-)) understand the role receptor-sensing pathways arthritis autoantibody production. Using triple knockout (TKO) mice deficient DNase II/IFNaR together with deficiency either stimulator...
Abstract Most systemic lupus erythematosus (SLE) patients are photosensitive and ultraviolet B light (UVB) exposure worsens cutaneous disease precipitates flares of disease. The pathogenic link between skin exacerbations in SLE remains elusive. In an acute model UVB-triggered inflammation, we observed that a single UV triggered striking IFN-I signature not only the skin, but also blood kidneys. early was significantly higher female compared to male mice. response almost entirely, partly,...
Phagocytic macrophages and dendritic cells are desirable targets for potential RNAi (RNA interference) therapeutics because they often mediate pathogenic inflammation autoimmune responses. We recently engineered a complex 5 component glucan-based encapsulation system siRNA (small interfering RNA) delivery to phagocytes. In experiments designed simplify this original formulation, we discovered that the amphipathic peptide Endo-Porter forms stable nanocomplexes with can potent gene silencing...
Autism spectrum disorder (ASD) is a common neurodevelopmental with reported prevalence in the United States of 1 59 children (approximately 1.7%). ASD significantly influences lives affected and families because they may need extensive behavioral, educational, health, other services. Primary care providers play critical role identifying, diagnosing, managing providing support for their families. This document provides summary clinical report "Identification, Evaluation, Management Children...
Developmental–behavioral pediatrics (DBP) subspecialists care for children with complex neurodevelopmental and behavioral health conditions; additional roles include education training, advocacy, research. In 2023, there were 1.0 DBP per 100 000 US aged 0 to 17 years (range 0.0–3.8), wide variability in subspecialist distribution. Given the prevalence of DB conditions, current workforce is markedly inadequate meet needs patients families. The American Board Pediatrics Foundation led a...
AbstractThe role of autophagy, a catabolic lysosome-dependent pathway, has recently been recognized in variety disorders, including Pompe disease, which results from deficiency the glycogen-degrading lysosomal hydrolase acid-alpha glucosidase (GAA). Skeletal and cardiac muscle are most severely affected by progressive expansion glycogen-filled lysosomes. In both humans an animal model disease (GAA KO), skeletal pathology also involves massive accumulation autophagic vesicles buildup core...
PGC-1α is a transcriptional co-activator that plays central role in the regulation of energy metabolism. Our interest this protein was driven by its ability to promote muscle remodeling. Conversion from fast glycolytic slow oxidative fibers seemed promising therapeutic approach Pompe disease, severe myopathy caused deficiency lysosomal enzyme acid alpha-glucosidase (GAA) which responsible for degradation glycogen. The recently approved replacement therapy (ERT) has only partial effect...
Objective Polymorphisms in the transcription factor interferon regulatory 5 (IRF5) are associated with an increased risk of developing rheumatoid arthritis (RA). This study was undertaken to determine role IRF5 a mouse model development. Methods K/BxN serum–transfer induced mice deficient IRF5, or lacking only myeloid cells, and severity evaluated. also TRIF, Toll‐like receptor 2 (TLR2), TLR3, TLR4, TLR7 pathways through which might promote arthritis. In vitro studies were performed...
Cytosolic DNA sensors detect microbial and promote type I interferon (IFN) proinflammatory cytokine production through the adaptor stimulator of IFN genes (STING) to resolve infection. Endogenous also engages STING pathway, contributing autoimmune disease. This study sought identify role in regulating bone formation define phenotype its pathophysiologic mechanisms arthritic mice double deficient DNase II IFN-α/β/ω receptor (IFNAR) (DNase II-/- /IFNAR-/- double-knockout [DKO] mice) compared...
BACKGROUND: The quality of care for children with attention-deficit/hyperactivity disorder (ADHD) delivered in community-based pediatric settings is often poor. Interventions have been developed to improve ADHD but not demonstrated that better results improved patient outcomes. objective this study was determine whether an improvement (QI) intervention practices improves METHODS: A cluster randomized controlled trial conducted which 50 primary (213 providers) were either receive a...