A5063702959- Bone health and osteoporosis research
- Bone health and treatments
- Bone Metabolism and Diseases
- Bone fractures and treatments
- Orthopaedic implants and arthroplasty
- Lower Extremity Biomechanics and Pathologies
- Bone and Joint Diseases
- Osteoarthritis Treatment and Mechanisms
- Hip disorders and treatments
- Elasticity and Material Modeling
- Bone Tissue Engineering Materials
- Vitamin D Research Studies
- Cellular Mechanics and Interactions
- Tendon Structure and Treatment
- Parathyroid Disorders and Treatments
- Forensic Anthropology and Bioarchaeology Studies
- Sports injuries and prevention
- Primate Behavior and Ecology
- Veterinary Orthopedics and Neurology
- Shoulder Injury and Treatment
- Hip and Femur Fractures
- Orthopedic Surgery and Rehabilitation
- Estrogen and related hormone effects
- Connective tissue disorders research
- Knee injuries and reconstruction techniques
Indiana University School of Medicine
2015-2024
Indiana University
2007-2024
Indiana University – Purdue University Indianapolis
2014-2023
East Asia School of Theology
2021
Niigata University of Rehabilitation
2021
University of Indianapolis
2007-2020
American Society for Bone and Mineral Research
2020
Institute of Cell Biology and Neurobiology
2003-2017
University School
1998-2015
Eli Lilly (United States)
2015
Abstract Reports linking long-term use of bisphosphonates (BPs) with atypical fractures the femur led leadership American Society for Bone and Mineral Research (ASBMR) to appoint a task force address key questions related this problem. A multidisciplinary expert group reviewed pertinent published reports concerning fractures, as well preclinical studies that could provide insight into their pathogenesis. case definition was developed so subsequent report on same condition. The defined major...
It has been hypothesized that suppression of bone remodeling allows microdamage to accumulate, leading increased fragility. This study evaluated the effects reduced turnover produced by bisphosphonates on accumulation and biomechanical properties cortical in dog rib. Thirty-six female beagles, 1-2 years old, were divided into three groups. The control group (CNT) was treated daily for 12 months with saline vehicle. remaining two groups risedronate (RIS) at a dose 0.5 mg/kg per day or...
Abstract Mechanical loading presents a potent osteogenic stimulus to bone cells, but cells desensitize rapidly mechanical stimulation. Resensitization must occur before the can transduce future signals effectively. Previous experiments show that protocols are more if load cycles divided into several discrete bouts, separated by hours, than applied in single uninterrupted bout. We investigated effect of bouts on structure and biomechanical properties rat ulna after 16 weeks loading. The right...
Mechanical force applied to bone produces two localized mechanical signals on the cell: deformation of extracellular matrix (substrate strain) and fluid flow. To study effects these stimuli osteoblasts, MC3T3-E1 cells were grown type I collagen-coated plastic plates subjected four-point bending. This technique uniform levels physiological strain forces cells. Each parameters can be varied independently. Osteopontin (OPN) mRNA expression was used assess anabolic response When low, neither...
Mechanical stimulation of bone induces new formation in vivo and increases the metabolic activity gene expression osteoblasts culture. We investigated role actin cytoskeleton actin-membrane interactions transmission mechanical signals leading to altered cultured MC3T3-E1 osteoblasts. Application fluid shear caused reorganization filaments into contractile stress fibers involved recruitment beta1-integrins alpha-actinin focal adhesions. Fluid also increased two proteins linked...
Abstract We studied changes in subchondral bone and articular cartilage an animal model of osteoarthrosis. In this we applied repetitive impulsive loads to rabbits' knees. Their legs were held short leg splints so the rabbits unable dampen peak load with ankle flexion. After sacrifice, at 1 day 6 weeks, proximal tibial load‐bearing histologically, biochemically, radioactive sulfate uptake. also under that histomorphometrically, scan ( 99m Tc pyrophosphate), by tetracycline labeling. An...