A5041688386- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Skin and Cellular Biology Research
- Immunotherapy and Immune Responses
- Child and Adolescent Health
- Cell Adhesion Molecules Research
- Sleep and Wakefulness Research
- Obsessive-Compulsive Spectrum Disorders
- Cerebral Palsy and Movement Disorders
- Systemic Sclerosis and Related Diseases
- Attention Deficit Hyperactivity Disorder
- EEG and Brain-Computer Interfaces
- Immune Response and Inflammation
- Dermatologic Treatments and Research
- Infant Development and Preterm Care
- Transcranial Magnetic Stimulation Studies
- Neural and Behavioral Psychology Studies
- Wound Healing and Treatments
- Pain Mechanisms and Treatments
- Psychosomatic Disorders and Their Treatments
- Family and Disability Support Research
Virginia Commonwealth University
2020-2024
University of California, San Francisco
1986-2024
UCSF Benioff Children's Hospital
2020-2024
University Health System
2024
University of Colorado Anschutz Medical Campus
2013-2023
Circuit Therapeutics (United States)
2023
Brigham and Women's Hospital
2023
University of Colorado Denver
2004-2022
Denver VA Medical Center
2016-2021
Louis Stokes Cleveland VA Medical Center
2020
Parkinson disease is a progressive neurologic disorder. Limited evidence suggests endurance exercise modifies severity, particularly high-intensity exercise.To examine the feasibility and safety of treadmill in patients with de novo who are not taking medication whether effect on motor symptoms warrants phase 3 trial.The Study Disease Exercise (SPARX) was 2, multicenter randomized clinical trial groups masked assessors. Individuals from outpatient community-based clinics were enrolled May 1,...
Estimates of children and adolescents with disabilities worldwide are needed to inform global intervention under the disability-inclusive provisions Sustainable Development Goals. We sought update most widely reported estimate 93 million <15 years from Global Burden Disease Study 2004.
Human peripheral blood mononuclear cells activated with concanavalin A (Con A) or lipopolysaccharide (LPS) produce, respectively, lymphokines (LK) of 50,000 Mr monokines (MK) 20,000 that inhibit the growth and collagen production cultured human dermal fibroblasts. Because antigenic typing antiviral activity these LK MK preparations revealed contained mainly gamma interferon (IFN-gamma), MK, primarily IFN-beta, we investigated if any fibroblast-inhibiting activities could be attributed to...
Neuroleptic malignant syndrome (NMS) is a life-threatening idiosyncratic reaction to antipsychotic drugs characterized by fever, altered mental status, muscle rigidity, and autonomic dysfunction. It has been associated with virtually all neuroleptics, including newer atypical antipsychotics, as well variety of other medications that affect central dopaminergic neurotransmission. Although uncommon, NMS remains critical consideration in the differential diagnosis patients presenting fever...
Abstract Background The Movement Disorder Society‐Sponsored Revision of the Unified Parkinson's Disease Rating Scale ( MDS ‐ UPDRS ) is a commonly used tool to measure progression in patients with disease PD ). Longitudinal changes scores de novo have not been established. objective this study was determine rates . Methods In total, 362 participants from Progression Markers Initiative, multicenter, longitudinal cohort , were included. total and subscale modeled using mixed model regression....
<i>Background:</i> Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is an effective and well-tolerated treatment for idiopathic generalized dystonia. More recently, it has been applied as a focal segmental dystonias. This patient population offers opportunity to study effects alteration pallidal outflow on previously normal limb function. <i>Methods:</i> We sought retrospectively characterize extent novel GPi DBS-induced adverse motor in patients...
<h3>Objective:</h3> To investigate the safety and efficacy of intermittent theta-burst stimulation (iTBS) in treatment motor symptoms Parkinson disease (PD). <h3>Background:</h3> Progression PD is characterized by emergence deficits, which eventually respond less to dopaminergic therapy pose a therapeutic challenge. Repetitive transcranial magnetic (rTMS) has shown promising results improving gait, major cause disability, may provide alternative. iTBS novel type rTMS that be more efficacious...
To determine the therapeutic potential of interferon (IFN) treatment for Peyronie's disease, we investigated effect human recombinant (hu-r) IFNs on cultured fibroblasts derived from a disease penile plaque. Treatment with hu-r-IFN-alpha2b, hu-r-IFN-beta-ser17 and hu-r-IFN gamma caused concentration dependent inhibition both fibroblast proliferation collagen production, as well an increase in collagenase production. Hu-r-IFN-alpha beta had no glycosaminoglycan (GAG) or fibronectin while...
Journal Article Anatomical mapping of epidermal Langerhans cell densities in adults Get access B. BERMAN, BERMAN Department Dermatology, Mount Sinai School Medicine, New York, York 10029, U. S. A. Dr Brian Berman, Dermatology Service, V. Medical Center, 150 Muir Road, Martinez, CA 94553, Search for other works by this author on: Oxford Academic Google Scholar L. CHEN, CHEN D. FRANCE, FRANCE W. I. DOTZ, DOTZ G. PETRONI British Volume 109, Issue 5, 1 November 1983, Pages 553–558,...
Spasmodic dysphonia is a primary focal dystonia characterized by involuntary spasms in the laryngeal muscles during speech production. The pathophysiology of spasmodic thought to involve structural and functional abnormalities basal ganglia–thalamo-cortical circuitry; however, neurochemical correlates underpinning these as well their relations symptoms remain unknown. We used positron emission tomography with radioligand [ 11 C]raclopride (RAC) study striatal dopaminergic neurotransmission...
Depression and anxiety frequently accompany the motor manifestations of isolated adult-onset focal dystonias. Whether body region affected when this type dystonia first presents is associated with severity these neuropsychiatric symptoms unknown.The aim study was to determine whether depression, social vary by onset site evaluate pain account for any differences.Patients evaluated within 5 years from symptom onset, enrolled in Natural History Project Dystonia Coalition, were included...
PD is associated with disrupted connectivity to a large number of distributed brain regions. How the disease alters functional topological organization brain, however, remains poorly understood. Furthermore, how levodopa modulates network topology in largely unknown. The objective this study was use resting-state MRI and graph theory determine small-world architecture altered affected by administration.Twenty-one patients 20 controls underwent scanning. were scanned off medication 1 hour...
Objective Isolated focal dystonia can spread to muscles beyond the initially affected body region, but risk of has not been evaluated in a prospective manner. Furthermore, regions at for and clinical factors associated with are well characterised. We sought here prospectively characterise recently diagnosed adult-onset isolated patients. Methods Patients enrolled Dystonia Coalition affecting only neck, upper face, hand or larynx onset symptoms were included. Timing follow-up visits was based...
To assess the clinical manifestations and predictors of different types tremors in individuals with isolated dystonia.Clinical tremor were assessed a multicenter, international cross-sectional, cohort study 2,362 all dystonia (focal, segmental, multifocal, generalized) recruited through Dystonia Coalition.Methodical standardized assessments participants this revealed overall prevalence any type was 53.3%. The dystonic varied from 36.9% to 48.4%, depending on criteria used define it. identify...
Transient exposure to inflammation-associated, fibroblast-stimulatory factors appears initiate fibrosis by inducing the persistently activated phenotypes displayed fibroblast cultures derived from scleroderma skin and other fibrotic tissues. To determine whether one class of fibroblast-inhibitory factors, interferons (IFNs), plays a role in terminating acting as persistent deactivators, we inhibited (40-60%) growth collagen production normal dermal fibroblasts hypercollagen-producing...