A5055371991- Botulinum Toxin and Related Neurological Disorders
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Pain Mechanisms and Treatments
- Ophthalmology and Eye Disorders
- Advanced Sensor and Energy Harvesting Materials
- Hereditary Neurological Disorders
- Epilepsy research and treatment
- Transcranial Magnetic Stimulation Studies
- Plant-based Medicinal Research
- Pediatric Pain Management Techniques
- Trigeminal Neuralgia and Treatments
- Neurological diseases and metabolism
- Ultrasound and Hyperthermia Applications
- Electrospun Nanofibers in Biomedical Applications
- Simulation-Based Education in Healthcare
- Thyroid Disorders and Treatments
- Musculoskeletal pain and rehabilitation
- Neurological and metabolic disorders
- Glycogen Storage Diseases and Myoclonus
- Anesthesia and Pain Management
- Infant Development and Preterm Care
- Tryptophan and brain disorders
- Telemedicine and Telehealth Implementation
Neurology, Inc
2025
Emory University
2015-2024
The Neurological Institute
2020
Louis Stokes Cleveland VA Medical Center
2020
Georgia Urology
2019
Southern California University for Professional Studies
2016
University of Southern California
2016
Haverford College
2004
To assess the clinical manifestations and predictors of different types tremors in individuals with isolated dystonia.Clinical tremor were assessed a multicenter, international cross-sectional, cohort study 2,362 all dystonia (focal, segmental, multifocal, generalized) recruited through Dystonia Coalition.Methodical standardized assessments participants this revealed overall prevalence any type was 53.3%. The dystonic varied from 36.9% to 48.4%, depending on criteria used define it. identify...
Objective: Blepharospasm is a type of dystonia where the diagnosis often delayed because its varied clinical manifestations are not well recognized. The purpose this study was to provide comprehensive picture features including presenting features, motor and non-motor features. Methods: This two-part study. first part involved systematic literature review that summarized for 10,324 cases taken from 41 prior reports. second summary 884 enrolled in large multicenter cohort collected by...
The long-term consequences of neonatal noxious stimulation on adulthood pain behavior were investigated in male and female mice. On the day birth, mouse pups exposed to a laparotomy under cold anesthesia followed by an analgesic dose morphine (10 mg/kg) post-operatively, or saline control. An additional group subjects was non-noxious aspects surgical procedure (cold exposure, separation from dam, injection) comprising 'sham' surgery control group, whereas another administered injection...
Objective: The goal of this study is to better characterize the phenotypic heterogeneity oromandibular dystonia (OMD) for purpose facilitating early diagnosis. Methods: First, we provide a comprehensive summary literature encompassing 1,121 cases. Next, describe clinical features 727 OMD subjects enrolled by Dystonia Coalition (DC), an international multicenter cohort. Finally, summarize and treatment outcomes from cross-sectional analysis 172 two expert centers. Results: In all cohorts,...
There remains an urgent need to identify preclinical pathophysiological mechanisms of Alzheimer's disease (AD) development in high-risk, racially diverse populations. We explored the relationship between cerebrospinal fluid (CSF) markers vascular injury and neuroinflammation with AD biomarkers middle-aged Black/African American (B/AA) non-Hispanic White (NHW) participants.
Telemedicine has rapidly gained momentum in movement disorder neurology during the coronavirus disease (COVID-19) pandemic to preserve clinical care while mitigating risks of in-person visits. We present data from rapid implementation virtual visits a large, academic, practice COVID-19 pandemic.
Deep brain stimulation (DBS) for Parkinson's disease (PD) is generally contraindicated in persons with dementia but it frequently performed people mild cognitive impairment or normal cognition, and current clinical guidelines are primarily based on these cohorts.
Neuroprotective properties of estrogen have poorly translated to reduced neurodegeneration in clinical trials systemic replacement therapy. To more directly assess biological processes associated with brain (estrone, estradiol) levels, we recruited 81 women (42 non-white) and 28 men (13 for cerebrospinal fluid (CSF) proteomic volumetric analysis. In these mostly post-menopausal women, found low CSF levels only modest correlate their corresponding plasma levels. Aptamer-based analysis markers...
Blepharospasm (BL) is characterized by involuntary closures of the eyelids due to spasms orbicularis oculi muscle. The gold standard for clinical evaluation BL involves visual inspection manual rating scales. This approach highly subjective and error prone. Unfortunately, there are currently no simple quantitative systems accurate objective diagnostics BL. Here, we introduce a soft, flexible hybrid bioelectronic system that offers conformal, gentle lamination on skin, while enabling...
Abstract Background Blepharospasm is treated with botulinum toxin, but obtaining satisfactory results sometimes challenging. Objective The aim to conduct an exploratory trial of oral dipraglurant for blepharospasm. Methods This study was exploratory, phase 2a, randomized, double‐blind, placebo‐controlled 15 participants who were assigned receive a placebo or (50 100 mg) and assessed over 2 days, 1 hours following dosing. Outcome measures included multiple scales rated by clinicians...
Abstract Background Prior studies have indicated that female individuals outnumber male for certain types of dystonia. Few addressed factors impacting these sex differences or their potential biological mechanisms. Objectives To evaluate underlying in the dystonias and explore mechanisms differences. Methods Data from with various dystonia were analyzed relation to sex. came two different sources. One source was Dystonia Coalition database, which contains predominantly idiopathic adult‐onset...
ABSTRACT Background Assessing disease severity can be performed using either clinician‐rated scales (CRS) or patient‐rated outcome (PRO) tools. These two measures frequently demonstrate poor correlations. Objectives To determine if the correlation between a CRS and PRO for motor features of cervical dystonia (CD) improves by accounting non‐motor features. Methods Subjects with CD (N = 209) were evaluated (Toronto Western Spasmodic Torticollis Rating Scale, TWSTRS) (Cervical Dystonia Impact...
Recent advances in flexible materials, nanomanufacturing, and system integration have provided a great opportunity to develop wearable hybrid electronics for human healthcare, diagnostics, therapeutics. However, existing medical devices still rely on rigid with many wires separate components, which hinders wireless, comfortable, continuous monitoring of health-related motions. Here, we introduce advanced materials technologies that enable soft, active thin-film bioelectronics. The...
ABSTRACT Introduction Tardive syndrome (TS) is an often irreversible movement disorder caused by dopamine receptor‐blocking agents (DRBAs). Although TS are well recognized to occur with typical antipsychotics, less appreciated that atypical antipsychotics also carry a risk of TS. Methods Case series. Results We describe 4 patients who developed tardive dystonia, akathisia, and drug‐induced parkinsonism the use antipsychotic, lurasidone, which was U.S. Food Drug Administration approved in...
To assess relationship of tremor reduction and volume lesion post Focused Ultrasound (FUS) therapy in Essential Tremor (ET) Parkinson Disease (PD) patients.
ABSTRACT Background Several monogenic causes for isolated dystonia have been identified, but they collectively account only a small proportion of cases. Two genome‐wide association studies reported few potential risk loci; conclusions limited by sample sizes, partial coverage genetic variants, or poor reproducibility. Objective To identify robust variants and loci in large multicenter cervical cohort using approach. Methods We performed study samples from the Dystonia Coalition. Logistic...