A5057415063- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Genetic Neurodegenerative Diseases
- Transcranial Magnetic Stimulation Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Obsessive-Compulsive Spectrum Disorders
- Parkinson's Disease and Spinal Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Advanced MRI Techniques and Applications
- Attention Deficit Hyperactivity Disorder
- Glycogen Storage Diseases and Myoclonus
- Autism Spectrum Disorder Research
- Neuroscience and Neural Engineering
- Voice and Speech Disorders
- Orthodontics and Dentofacial Orthopedics
- Periodontal Regeneration and Treatments
- Pain Management and Treatment
- Neurological diseases and metabolism
- EEG and Brain-Computer Interfaces
- PARP inhibition in cancer therapy
- Phonocardiography and Auscultation Techniques
- Anesthesia and Neurotoxicity Research
Rush University Medical Center
2021-2025
Henry Ford Health System
2016-2023
Rush University
2023
SMT (India)
2022
Sardar Vallabhbhai National Institute of Technology Surat
2022
Henry Ford Hospital
2016-2021
The Neurological Institute
2020
Louis Stokes Cleveland VA Medical Center
2020
Hospital of the University of Pennsylvania
2020
Amyotrophic Lateral Sclerosis Association
2018
To assess the clinical manifestations and predictors of different types tremors in individuals with isolated dystonia.Clinical tremor were assessed a multicenter, international cross-sectional, cohort study 2,362 all dystonia (focal, segmental, multifocal, generalized) recruited through Dystonia Coalition.Methodical standardized assessments participants this revealed overall prevalence any type was 53.3%. The dystonic varied from 36.9% to 48.4%, depending on criteria used define it. identify...
Objective To evaluate the relationship between health-related quality of life (HR-QoL) and both physical psychiatric factors in a large, international, multicentre cohort patients with isolated dystonia, Dystonia Coalition. Methods Natural history data from 603 dystonia (median age 57 years (IQR: 48 to 64 years), 67.0% women) were prospectively acquired analysed. HR-QoL (RAND 36-Item Health Survey), severity depressive symptoms, generalised anxiety (Hospital Anxiety Depression Scale) social...
Outcomes after deep brain stimulation (DBS) therapy are dependent on good surgical placement in the target nucleus and optimized parameters through multiple programming sessions. This often requires frequent travel to a specialized DBS center, which presents challenge for those with limited access. Recently, FDA approved remote tele-programming solution DBS. To determine if of systems is beneficial useful Parkinson's Disease (PD) patients, Foundation hosted survey collaboration Abbott...
The Movement Disorders Society recommends the DYT/PARK prefix for genes where dystonia and parkinsonism are prominent in approximately half or more of patients. This systematic review explores genotype–phenotype correlations GLB1, SLC6A3, SLC30A10, PLA2G6, SLC39A14—recently classified as DYT SLC39A14 historically linked to dystonia-parkinsonism. We searched PubMed Human Gene Mutation Database using standardized terms, including English-language, peer-reviewed publications up February 2024....
Some patients may experience tolerance to chronic ventral intermediate (ViM) thalamic deep brain stimulation (DBS), which include habituation (loss of sustained tremor control over weeks days after an adjustment) and rebound (a temporary increase in intensity stopping DBS). We observed association between these efficacy limiting phenomena with co-morbid demyelinating sensorimotor peripheral neuropathy (MRT-PN). The clinical treatment characteristics pre- post-DBS are described through...
Magnetic resonance-guided focused ultrasound (MRgFUS) is an effective treatment option for essential tremor (ET) and dominant Parkinson's disease (TDPD), which often performed with sedation or in the presence of anesthesiologist effort to minimize adverse events maximize patient comfort. This study explores safety, feasibility, tolerability performing MRgFUS without anesthesiologist.
Cervical dystonia (CD) patients have impaired working memory, processing speed and visual-motor integration ability. We used magnetoencephalography (MEG) to investigate changes in cerebral oscillations CD during an executive function test, before after administration of botulinum toxin.MEG data were collected from five while they performed a visual continuous performance task (CPT), received toxin injection. MEG was also on controls matched for age gender. Coherence source imaging quantify...
Pseudobulbar affect (PBA) is a syndrome of affective disturbance associated with inappropriate laughter and crying, independent mood. PBA common in amyotrophic lateral sclerosis (ALS) increasingly recognized Parkinson’s disease (PD) atypical parkinsonism (aP). Correlates have not been systematically studied. The purpose this study was to determine whether cognitive psychiatric comorbidities correlated patient-reported symptoms by using the Center for Neurological Study–Lability Scale among...
ABSTRACT Background Several monogenic causes for isolated dystonia have been identified, but they collectively account only a small proportion of cases. Two genome‐wide association studies reported few potential risk loci; conclusions limited by sample sizes, partial coverage genetic variants, or poor reproducibility. Objective To identify robust variants and loci in large multicenter cervical cohort using approach. Methods We performed study samples from the Dystonia Coalition. Logistic...
The initial COVID-19 pandemic shutdown led to the canceling of elective surgeries throughout most USA and Canada.This survey was carried out on behalf Parkinson Study Group (PSG) understand impact deep brain stimulation (DBS) practices in North America.A distributed through RedCap® members PSG Functional Neurosurgical Working Group. Only one member from each site asked respond survey. Responses were collected May 15 June 6, 2020.Twenty-three sites participated; 19 (83%) 4 (17%) Canada....
Magnetic resonance-guided focused ultrasound (MRgFUS) represents an incisionless treatment option for essential or parkinsonian tremor. The nature of this procedure has garnered interest from both patients and providers. As such, increasing number centers are initiating new MRgFUS programs, necessitating development unique workflows to optimize patient care safety. Herein, we describe establishment a multi-disciplinary team, workflow processes, outcomes program.This is single-academic center...
To develop a process to improve patient outcomes from deep brain stimulation (DBS) surgery for Parkinson disease (PD), essential tremor (ET), and dystonia.We employed standard quality improvement methodology using the Plan-Do-Study-Act selection, surgical DBS lead implantation, postoperative programming, ongoing assessment of outcomes.The result this was development neuromodulation network. The key aspect program is rigorous both motor non-motor tracked longitudinally REDCap database. We...
We assessed differences in metrics of functional and patient-reported outcomes among patients with Parkinson's Disease (PD) who underwent subthalamic nucleus (STN) deep brain stimulation (DBS) via either awake or asleep surgical technique by a single surgeon at our center.