A5017611799- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Stress Responses and Cortisol
- EEG and Brain-Computer Interfaces
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Functional Brain Connectivity Studies
- Psychology of Moral and Emotional Judgment
- Biomedical and Chemical Research
- Vestibular and auditory disorders
- Neuroendocrine regulation and behavior
- Evolutionary Psychology and Human Behavior
- Advanced Neuroimaging Techniques and Applications
- Action Observation and Synchronization
- Obsessive-Compulsive Spectrum Disorders
- Memory and Neural Mechanisms
- Medical and Health Sciences Research
- Neurotransmitter Receptor Influence on Behavior
- Psychosomatic Disorders and Their Treatments
- Attention Deficit Hyperactivity Disorder
- Behavioral Health and Interventions
- Parkinson's Disease Mechanisms and Treatments
- Medical Practices and Rehabilitation
- Physics and Engineering Research Articles
- Mental Health Research Topics
- Motor Control and Adaptation
University of Lübeck
2015-2024
Erasmus University Rotterdam
2022
Erasmus MC
2022
University Hospital Schleswig-Holstein
2016
Leibniz Institute of Environmental Medicine
2013-2014
Otto-von-Guericke University Magdeburg
2006-2010
University of California, Berkeley
2009-2010
University Hospital Magdeburg
2007-2008
University of Tübingen
2003-2005
Justus-Liebig-Universität Gießen
2003-2005
Parkinson’s disease (PD) is a neurodegenerative disorder affecting dopaminergic neurons in the substantia nigra leading to dysfunctional cortico-striato-thalamic-cortical loops. In addition characteristic motor symptoms, PD patients often show cognitive impairments, affective changes and other non-motor suggesting system-wide effects on brain function. Here, we used functional magnetic resonance imaging graph-theory based analysis methods investigate altered whole-brain intrinsic...
Language switching is omnipresent in bilingual persons. In fact, the ability to switch languages (code switching) a very fast, efficient and flexible process which seems be fundamental aspect of language processing. Here we aimed characterize individual differences psychometrically create reliable measure this behavioral pattern by introducing Bilingual Switching Questionnaire (BSWQ). As working hypothesis based on previous literature code decomposed into four constructs: (i) L1 tendencies...
The use of D2/D3 dopaminergic agonists in Parkinson's disease (PD) may lead to pathological gambling. In a placebo-controlled double-blind study healthy volunteers, we observed riskier choices lottery task after administration the D3 receptor-preferring agonist pramipexole thus mimicking risk-taking behavior PD. Moreover, demonstrate decreased activation rostral basal ganglia and midbrain, key structures reward system, following unexpected high gains therefore propose that gambling PD...
Abstract Obsessive‐compulsive disorder (OCD) is characterized by recurrent intrusive thoughts and ritualized, repetitive behaviors, or mental acts. Convergent experimental evidence from neuroimaging neuropsychological studies supports an orbitofronto‐striato‐thalamo‐cortical dysfunction in OCD. Moreover, over excitability of the amygdala monitoring actions involving anterior cingulate, frontal parietal cortex has been proposed as aspects pathophysiology We chose a data driven, graph...
Altered neural processing of social signals such as angry facial expressions has been associated with increased aggressive behavior, but evidence for this relationship in healthy persons using ecologically valid experimental designs is lacking. We presented socially relevant videos a functional magnetic resonance imaging (fMRI) version the well-established Taylor Aggression Paradigm and investigated 41 male participants, whom 32 were included analysis. In each round competitive reaction time...
Dynamic adaptations of one's behavior by means performance monitoring are a central function the human executive system, that underlies considerable interindividual variation. Converging evidence from electrophysiological and neuroimaging studies in both animals humans hints at importance dopaminergic system for regulation monitoring. Here, we studied impact two polymorphisms affecting functioning prefrontal cortex [catechol- O -methyltransferase (COMT) Val108/158Met dopamine D4 receptor...
Ouabain, an inhibitor of the sodium pump, has been identified as a constituent bovine adrenal glands. We were interested whether release this cardiotonic steroid is stimulated by physical exercise. Hence, athletes and healthy dogs subjected to ergometry. Ouabain-like compound (OLC) was measured in venous blood enzyme-linked immunosorbent assay well (86)Rb+ uptake inhibition (as ouabain equivalents). OLC increased after 15 minutes ergometry from 2.5+/-0.5 86.0+/-27.2 nmol/L (n=51; P<0.001),...
Changes in the environment require rapid modification or inhibition of ongoing behavior. We used stop-signal paradigm and intracranial recordings to investigate response preparation, inhibition, monitoring task-relevant information. Electrocorticographic data were recorded eight patients with electrodes covering frontal, temporal, parietal cortex, time-frequency analysis was examine power differences beta (13–30 Hz) high-gamma bands (60–180 Hz). Over motor decreased, increased during...
Abstract Bilateral vestibular failure (BVF) is a severe chronic disorder of the labyrinth or eighth cranial nerve characterized by unsteadiness gait and disabling oscillopsia during head movements. According to animal data, input hippocampus proposed contribute spatial memory navigation. Except for one seminal study showing association impaired navigation hippocampal atrophy, patient data in BVF are lacking. Therefore, we performed voxel‐wise comparison gray matter volume (GMV) clinically...
Abstract Individuals with hostile expectations (HEX) anticipate harm from seemingly neutral or ambiguous stimuli. However, it is unclear how HEX are acquired, and whether specific components of learning can predict antisocial thought, conduct, personality. In an online sample healthy young individuals ( n = 256, 69% women), we administered a virtual shooting task applied computational modelling behaviour to investigate its constellation correlates. acquisition was best explained by...
People's sensitivity to reinforcing stimuli such as monetary gains and losses shows a wide interindividual variation that might in part be determined by genetic differences. Because of the established role dopaminergic system neural encoding rewards negative events, we investigated young healthy volunteers being homozygous for either Valine or Methionine variant catechol-O-methyltransferase (COMT) codon 158 polymorphism well C T SNP −521 dopamine D4 receptor. Participants took gambling...
Abstract People are able to adapt their behavior changing environmental contingencies by rapidly inhibiting or modifying actions. Response inhibition is often studied in the stop-signal paradigm that requires suppression of an already prepared motor response. Less known about situations calling for a change plans such response has be withheld but another executed instead. In present study, we investigated whether electrophysiological data can provide evidence distinct inhibitory mechanisms...
Abstract Background Actions of others may have immediate consequences for oneself. We probed the neural responses associated with observation another person's action using event-related potentials in a modified gambling task. In this task "performer" bet either higher or lower number and could win lose amount. Three different groups "observers" were also studied. The first (neutral) group simply observed performer's action, which had no observers. second (parallel) group, wins/losses...
Reactive aggression after interpersonal provocation is a common behavior in humans. Little known, however, about brain regions and neurotransmitters critical for the decision-making affective processes involved aggressive interactions. With present fMRI study, we wanted to examine role of serotonin reactive by means an acute tryptophan depletion (ATD). Participants performed competitive reaction time task (Taylor Aggression Paradigm, TAP) which entitled winner punish loser. The TAP seeks...
Proactive motor inhibition refers to endogenous preparatory mechanisms facilitating action inhibition, whereas reactive is considered be a sudden stopping process triggered by external signals. Previous studies were inconclusive about the temporal dynamics of involved neurocognitive processes during proactive and control. Using electroencephalography (EEG), we investigated time-course measuring event-related oscillations potentials (ERPs). Participants performed in cued go/nogo paradigm with...