A5076235003- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Memory Processes and Influences
- Neuroscience and Neuropharmacology Research
- Neural and Behavioral Psychology Studies
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Neuroscience and Music Perception
- Neural Networks and Applications
- Behavioral Health and Interventions
- Sleep and Wakefulness Research
- Neuroscience and Neural Engineering
- Multisensory perception and integration
- Mental Health Research Topics
- Advanced Sensor and Energy Harvesting Materials
- Stress Responses and Cortisol
- Neurobiology of Language and Bilingualism
- Carbon Nanotubes in Composites
- Sleep and related disorders
- Climate Change Communication and Perception
- Child and Animal Learning Development
- Blind Source Separation Techniques
- Neurotransmitter Receptor Influence on Behavior
- Social and Intergroup Psychology
- Transcranial Magnetic Stimulation Studies
Universitat de Barcelona
2016-2025
Bellvitge University Hospital
2014-2025
Institut d'Investigació Biomédica de Bellvitge
2016-2025
Research Institute Hospital 12 de Octubre
2019
Neurosciences Institute
2019
Duran i Reynals Hospital
2013
University College London
2009-2011
Institució Catalana de Recerca i Estudis Avançats
2011
National Hospital for Neurology and Neurosurgery
2009-2011
Universitat Autònoma de Barcelona
2006
Decision-making invokes two fundamental axes of control: affect or valence, spanning reward and punishment, effect action, invigoration inhibition. We studied the acquisition instrumental responding in healthy human volunteers a task which we orthogonalized action requirements outcome valence. Subjects were much more successful learning active choices rewarded conditions, passive punished conditions. Using computational reinforcement-learning models, teased apart contributions from...
The acquisition of reward and the avoidance punishment could logically be contingent on either emitting or withholding particular actions. However, separate pathways in striatum for go no-go appear to violate this independence, instead coupling affect effect. Respect interdependence has biased many studies punishment, so potential action-outcome valence interactions during anticipatory phases remain unexplored. In a functional magnetic resonance imaging study with healthy human volunteers,...
Working memory allows information from transient events to persist as active neural representations [1Baddeley A. memory: Looking back and looking forward.Nat. Rev. Neurosci. 2003; 4: 829-839Crossref PubMed Scopus (3351) Google Scholar] that can be used for goal-directed behaviors such decision making learning [2Asaad W.F. Rainer G. Miller E.K. Neural activity in the primate prefrontal cortex during associative learning.Neuron. 1998; 21: 1399-1407Abstract Full Text PDF (436) Scholar, 3Fuster...
Animal models of human anxiety often invoke a conflict between approach and avoidance. In these, key behavioral assay comprises passive avoidance potential threat inhibition, both thought to be controlled by ventral hippocampus. Efforts translate these approaches clinical contexts are hampered the fact that it is not known whether humans manifest analogous approach-avoidance dispositions and, if so, they share homologous neurobiological substrate. Here, we developed paradigm investigate role...
Learning to fear danger in the environment is essential survival, but dysregulation of system at core many anxiety disorders. As a consequence, great interest has emerged developing strategies for suppressing memories maladaptive cases. Recent research focused process reconsolidation where become labile after being retrieved. In behavioral manipulation, Schiller et al., (2010) reported that extinction training, administrated during memory reconsolidation, could erase responses. The...
Recollection of contextual information represents the core human recognition memory. It has been associated with theta (4-8 Hz) power in electrophysiological recordings and, independently, BOLD effects a network including hippocampus and frontal cortex. Although notion coordinating neocortical activity by synchronization range is common among theoretical models recollection, direct evidence supporting this hypothesis scarce. To address apparent gap our understanding memory processes, we...
Long-term memories are linked to cortical representations of perceived events, but it is unclear which types can later be recollected. Using magnetoencephalography-based decoding, we examined brain activity patterns elicited during encoding replayed recollection in the human brain. The results show that images depicting faces and scenes associated with a replay neural formed at very early (180 ms) stages encoding. This occurs quite rapidly, ∼500 ms after onset cue prompts correlates source...
Segmentation of continuous experience into discrete events is driven by rapid fluctuations in encoding stability at context shifts (i.e., event boundaries), yet the mechanisms underlying online formation memories are poorly understood. We investigated neural per-time point spatial similarity patterns scalp electrophysiological (EEG) activity 30 human participants (male and female) watching a 50 min movie found that boundaries triggered reinstatement just-encoded EEG patterns. also onset...
Proactive and reactive inhibitory processes are a fundamental part of executive functions, allowing person to stop inappropriate responses when necessary adjust performance in long term accordance the goals task. In current study, we manipulate, single task, both proactive inhibition mechanisms, investigate within-subjects effect increasing, by means anodal transcranial direct stimulation (tDCS), involvement right inferior frontal cortex (rIFC). Our results show simultaneous enhancement...
This paper presents an extension of the Dynamic Causal Modelling (DCM) framework to analysis phase-coupled data. A weakly coupled oscillator approach is used describe dynamic phase changes in a network oscillators. The use Bayesian model comparison allows one infer mechanisms underlying synchronization processes brain. For example, whether activity driven by master-slave versus mutual entrainment mechanisms. Results are presented on synthetic data from physiological models and MEG study...
BackgroundRodent approach–avoidance conflict tests are common preclinical models of human anxiety disorder. Their translational validity mainly rests on the observation that anxiolytic drugs reduce rodent anxiety-like behavior. Here, we capitalized a recently developed computer game to investigate impact benzodiazepines and amygdala lesions putative In successive epochs this game, participants collect monetary tokens spatial grid while under threat virtual predation.MethodsIn preregistered,...
System memory consolidation is conceptualized as an active process whereby newly encoded representations are strengthened through selective reactivation during sleep. However, our learning experience highly overlapping in content (i.e., shares common elements), and memories of these events organized intricate network associated events. It remains to be explored whether how sleep has impact on acquired awake time. Here, we test a group adult women men the prediction that entails this may lead...
Learning about the social expectations tied to upcoming roles can prompt a strong drive for personal change, yet effective adaptation requires balancing this external pressure with preservation of stable self-views. Here, we use computational models provide mechanistic account how individuals at onset significant life transitions utilize their self-concept modulate self-role dissonances during role learning. We conducted two studies distinct populations important transitions: first-year...
Abstract Self-concept stability and cohesion are crucial for psychological functioning well-being, yet the mechanisms that underpin this fundamental aspect of human cognition remain underexplored. Integrating insights from cognitive personality psychology with reinforcement learning, we introduce Self-Utility Distance (SUD)—a metric quantifying dissimilarities between individuals’ self-concept attributes their expected utility value. In Study 1 ( n = 155), participants provided self- ratings...