A5005491067- Neural dynamics and brain function
- Visual perception and processing mechanisms
- Functional Brain Connectivity Studies
- Vestibular and auditory disorders
- EEG and Brain-Computer Interfaces
- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- Glaucoma and retinal disorders
- Ophthalmology and Eye Disorders
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neural and Behavioral Psychology Studies
- Motor Control and Adaptation
- Blind Source Separation Techniques
- Retinal Development and Disorders
- Neuroscience and Music Perception
- Ocular and Laser Science Research
- Gaze Tracking and Assistive Technology
- Neuroscience and Neural Engineering
- Geotechnical Engineering and Soil Stabilization
- Ophthalmology and Visual Impairment Studies
- Solar and Space Plasma Dynamics
- Non-Invasive Vital Sign Monitoring
- Tactile and Sensory Interactions
- Neurological disorders and treatments
University College London
2016-2025
National Hospital for Neurology and Neurosurgery
2016-2025
Ashford and St Peter's Hospitals NHS Foundation Trust
2024
Wellcome Centre for Human Neuroimaging
2015-2024
St Peter's Hospital
2024
Petersfield Community Hospital
2023
MRC Human Immunology Unit
2022
University of Manchester
2008-2020
Manchester Academic Health Science Centre
2020
University College Lahore
2016
In recent years the study of resting state brain networks (RSNs) has become an important area neuroimaging. The majority studies have used functional magnetic resonance imaging (fMRI) to measure temporal correlation between blood-oxygenation-level–dependent (BOLD) signals from different areas. However, BOLD is indirect related hemodynamics, and electrophysiological basis connectivity spatially separate network nodes cannot be comprehensively assessed using this technique. paper we describe a...
Magnetoencephalographic (MEG) recordings are a rich source of information about the neural dynamics underlying cognitive processes in brain, with excellent temporal and good spatial resolution. In recent years there have been considerable advances MEG hardware developments methods. Sophisticated analysis techniques now routinely applied continuously improved, leading to fascinating insights into intricate processes. However, rapidly increasing level complexity different steps study make it...
SPM is a free and open source software written in MATLAB (The MathWorks, Inc.). In addition to standard M/EEG preprocessing, we presently offer three main analysis tools: (i) statistical of scalp-maps, time-frequency images, volumetric 3D reconstruction images based on the general linear model, with correction for multiple comparisons using random field theory; (ii) Bayesian reconstruction, including support group studies, simultaneous EEG MEG, fMRI priors; (iii) dynamic causal modelling...
Functional connectivity (FC) between brain regions is thought to be central the way in which processes information. Abnormal implicated a number of diseases. The ability study FC therefore key goal for neuroimaging. (fc) MRI has become popular tool make measurements but technique limited by its indirect nature. A multimodal approach an attractive means investigate electrodynamic mechanisms underlying hemodynamic connectivity. In this paper, we resting state using fcMRI and...
The brain consists of functional units with more-or-less specific information processing capabilities, yet cognitive functions require the co-ordinated activity these spatially separated units. Magnetoencephalography (MEG) has temporal resolution to capture frequency-dependent interactions, although, due volume conduction and field spread, spurious estimates may be obtained when connectivity is estimated on basis extra-cranial recordings directly. Connectivity reconstructed sources similarly...
Advances in the field of quantum sensing mean that magnetic sensors, operating at room temperature, are now able to achieve sensitivity similar cryogenically cooled devices (SQUIDs). This means temperature magnetoencephalography (MEG), with a greatly increased flexibility sensor placement can be considered. Further, these new sensors placed directly on scalp surface giving, theoretically, large increase magnitude measured signal. Here, we present recordings made using single optically-pumped...
A number of recent studies have begun to show the promise magnetoencephalography (MEG) as a means non-invasively measure functional connectivity within distributed networks in human brain. However, problems with methodology still remain — biggest these being how deal non-independence voxels source space, often termed signal leakage. In this paper we demonstrate method by which non-zero lag cortico-cortical interactions between power envelopes neural oscillatory processes can be reliably...
1. Experiments have been conducted on human subjects in an attempt to establish the role of vestibulo‐ocular reflex co‐ordination head and eye movements during visual target acquisition. 2. When subject moved eyes acquire targets horizontal plane, movement consisted initial saccade direction followed by a slower return towards orbital centre which compensated for remaining movement. 3. was either voluntarily or passively dark pattern very similar that seen 4. The mean latency between start...
Small, commercially-available Optically Pumped Magnetometers (OPMs) can be used to construct a wearable Magnetoencephalography (MEG) system that allows large head movements made during recording. The small dynamic range of these sensors however means movement in the residual static magnetic field found inside typical Magnetically Shielded Rooms (MSRs) saturate sensor outputs, rendering data unusable. This problem ameliorated by using set electromagnetic coils attenuate spatially-varying...
Motor cortical beta activity (13–30 Hz) is a hallmark signature of healthy and pathological movement, but its behavioural relevance remains unclear. Using high-precision magnetoencephalography (MEG), we show that during the classical event-related desynchronisation (ERD) synchronisation (ERS) periods, motor in individual trials (n > 12,000) dominated by high amplitude, transient, infrequent bursts. Beta burst probability closely matched trial-averaged amplitude both pre- post-movement bursts...
Magnetoencephalography (MEG) is a sophisticated tool which yields rich information on the spatial, spectral and temporal signatures of human brain function. Despite unique potential, MEG limited by low signal-to-noise ratio (SNR) caused both inherently small magnetic fields generated brain, scalp-to-sensor distance. The latter in current systems due to requirement for pickup coils be cryogenically cooled. Recent work suggests that optically-pumped magnetometers (OPMs) might viable...
Statistical Parametric Mapping (SPM) is an integrated set of methods for testing hypotheses about the brain's structure and function, using data from imaging devices. These are implemented in open source software package, SPM, which has been continuous development more than 30 years by international community developers. This paper reports release SPM 25.01, a major new version that incorporates novel analysis methods, optimisations existing as well improved practices science development.
1. Experiments have been conducted on human subjects to determine the role of prediction in smooth eye movement control. Subjects were required actively pursue a small target or stare passively at larger display as it moved horizontal plane. 2. Target motion was basically periodic, but, after random number cycles an unexpected change made amplitude, direction frequency motion. Initially, periodic stimulus took form square waveform. In subsequent experiments, triangular sawtooth waveform...
To further our understanding of the cortical deficit in strabismic amblyopia, we measured, compared and mapped functional magnetic resonance imaging (fMRI) activation between fixing fellow amblyopic eyes ten amblyopes. Of specific concern was whether function any visual area spared as recently suggested by both positron emission tomography (PET) fMRI studies, there a close relationship response known psychophysical deficits. answer these questions measured each subject used stimuli whose to...
Oculomotor response in the absence of vision has been compared a group 12 normal humans two experimental conditions testing (a) vestibuloocular reflex by whole-body oscillation on turntable, and (b) cervico-ocular body with head held stationary. The stimulus was sinusoidal (peak angular velocity 50/sec) at frequencies between 0.2 1.3 Hz. slow-phase eye movements vestibulo-ocular were compensatory for movement showed mean gain 0.54–0.90. increasing frequency. cervicoocular found to be very...
Pneumomediastinum may result from a variety of causes that be either intrathoracic (eg, narrowed or plugged airway, straining against closed glottis, blunt chest trauma, alveolar rupture) extrathoracic sinus fracture, iatrogenic manipulation in dental extraction, perforation hollow viscus [corrected]. The radiographic signs pneumomediastinum depend on the depiction normal anatomic structures are outlined by air as it leaves mediastinum. These include thymic sail sign, "ring around artery"...