A5031526488- Functional Brain Connectivity Studies
- Atomic and Subatomic Physics Research
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Magnetic and transport properties of perovskites and related materials
- Muscle activation and electromyography studies
- Non-Invasive Vital Sign Monitoring
- Electromagnetic Fields and Biological Effects
- Cold Atom Physics and Bose-Einstein Condensates
- Neural Networks and Applications
- Ergonomics and Musculoskeletal Disorders
- Meningioma and schwannoma management
- Optical Imaging and Spectroscopy Techniques
- Neurofibromatosis and Schwannoma Cases
- Visual perception and processing mechanisms
- Soft tissue tumors and treatment
University of Nottingham
2018-2025
Dantec Dynamics (United Kingdom)
2024-2025
University of Naples Federico II
2024
Peking University
2024
QuSpin (United States)
2024
Hospital for Sick Children
2024
Nottingham University Hospitals NHS Trust
2024
Queen's Medical Centre
2024
Magnetoencephalography (MEG) is a powerful technique for functional neuroimaging, offering non-invasive window on brain electrophysiology. MEG systems have traditionally been based cryogenic sensors which detect the small extracranial magnetic fields generated by synchronised current in neuronal assemblies, however, such fundamental limitations. In recent years, non-cryogenic quantum-enabled sensors, called optically-pumped magnetometers (OPMs), combination with novel techniques accurate...
Small, commercially-available Optically Pumped Magnetometers (OPMs) can be used to construct a wearable Magnetoencephalography (MEG) system that allows large head movements made during recording. The small dynamic range of these sensors however means movement in the residual static magnetic field found inside typical Magnetically Shielded Rooms (MSRs) saturate sensor outputs, rendering data unusable. This problem ameliorated by using set electromagnetic coils attenuate spatially-varying...
Optically-pumped magnetometers (OPMs) are an established alternative to superconducting sensors for magnetoencephalography (MEG), offering significant advantages including flexibility accommodate any head size, uniform coverage, free movement during scanning, better data quality and lower cost. However, OPM sensor technology remains under development; there is regarding design it not yet clear which variant will prove most effective MEG. Most OPM-MEG implementations have either used...
The optically pumped magnetometer (OPM) is a viable means to detect magnetic fields generated by human brain activity. Compared conventional detectors (superconducting quantum interference devices) OPMs are small, lightweight, flexible, and operate without cryogenics. This has led step change in instrumentation for magnetoencephalography (MEG), enabling "wearable" scanner platform, adaptable fit any head size, able acquire data whilst subjects move, offering improved quality. Although many...
Optically-pumped magnetometers (OPMs) offer the potential for a step change in magnetoencephalography (MEG) enabling wearable systems that provide improved data quality, accommodate any subject group, allow capture during movement and potentially reduce cost. However, OPM-MEG is nascent technology and, to realise its potential, it must be shown facilitate key neuroscientific measurements, such as characterisation of brain networks. Networks, connectivities underlie them, have become core...
Optically pumped magnetometers (OPMs) are an emerging lightweight and compact sensor that can measure magnetic fields generated by the human brain. OPMs enable construction of wearable magnetoencephalography (MEG) systems, which offer advantages over conventional instrumentation. However, when trying to signals at low frequency, higher levels inherent noise, interference movement artefact introduce a significant challenge. Accurate characterisation frequency brain is important for...
Abstract The human brain undergoes significant functional and structural changes in the first decades of life, as foundations for cognition are laid down. However, non-invasive imaging techniques to investigate function throughout neurodevelopment limited due growth head-size with age substantial head movement young participants. Experimental designs probe also by unnatural environment typical systems impose. developments quantum technology allowed fabrication a new generation wearable...
To allow wearable magnetoencephalography (MEG) recordings to be made on unconstrained subjects the spatially inhomogeneous remnant magnetic field inside magnetically shielded room (MSR) must nulled. Previously, a large bi-planar coil system which produces uniform fields and gradients was used for this purpose. Its construction presented significant challenge, six distinct coils were wound two 1.6 × m2 planes. Here, we exploit shared symmetries produce simultaneously optimised generate...
Optically-pumped magnetometers (OPMs) are highly sensitive, compact magnetic field sensors, which offer a viable alternative to cryogenic sensors (superconducting quantum interference devices – SQUIDs) for magnetoencephalography (MEG). With the promise of wearable system that offers lifespan compliance, enables movement during scanning, and provides higher quality data, OPMs could drive step change in MEG instrumentation. However, this potential can only be realised if background fields...
Traditional magnetoencephalographic (MEG) brain imaging scanners consist of a rigid sensor array surrounding the head; this means that they are maximally sensitive to superficial structures. New technology based on optical pumping we can now consider more flexible and creative placement. Here explored magnetic fields generated by model human hippocampus not only across scalp but also at roof mouth. We found simulated hippocampal sources gave rise dipolar field patterns with one surface...
Magnetically shielded rooms (MSRs) use multiple layers of materials such as MuMetal to screen external magnetic fields that would otherwise interfere with high precision field measurements magnetoencephalography (MEG). Optically pumped magnetometers (OPMs) have enabled the development wearable MEG systems which potential provide a motion tolerant functional brain imaging system spatiotemporal resolution. Despite significant promise, OPMs impose stringent shielding requirements, operating...
Magnetoencephalography (MEG) measures the small magnetic fields generated by current flow in neural networks, providing a noninvasive metric of brain function. MEG is well established as powerful neuroscientific and clinical tool. However, instrumentation hampered cumbersome cryogenic field-sensing technologies. In contrast, using optically pumped magnetometers (OPM-MEG) employs small, lightweight, noncryogenic sensors that provide data with higher sensitivity spatial resolution, natural...
Magnetoencephalography (MEG) has been revolutionised by optically pumped magnetometers (OPMs). "OPM-MEG" offers higher sensitivity, better spatial resolution, and lower cost than conventional instrumentation based on superconducting quantum interference devices (SQUIDs). Moreover, because OPMs are small, lightweight, portable they offer the possibility of lifespan compliance (with control background field) motion robustness, dramatically expanding range MEG applications. However, OPM-MEG...
The ability to collect high-quality neuroimaging data during ambulatory participant movement would enable a wealth of neuroscientific paradigms. Wearable magnetoencephalography (MEG) based on optically pumped magnetometers (OPMs) has the potential allow scan. However, strict zero magnetic field requirement OPMs means that systems must be operated inside magnetically shielded room (MSR) and also require active shielding using electromagnetic coils cancel residual fields changes (due external...
The evolution of human cognitive function is reliant on complex social interactions which form the behavioural foundation who we are. These capacities are subject to dramatic change in disease and injury; yet their supporting neural substrates remain poorly understood. Hyperscanning employs functional neuroimaging simultaneously assess brain activity two individuals offers best means understand basis interaction. However, present technologies limited, either by poor performance (low...
Abstract The measurement of electrophysiology is critical importance to our understanding brain function. However, current non-invasive measurements—electroencephalography (EEG) and magnetoencephalography (MEG)—have limited sensitivity, particularly compared invasive recordings. Optically-Pumped Magnetometers (OPMs) are a new type magnetic field sensor which ostensibly promise MEG systems with higher sensitivity; however, the noise floor OPMs remains high cryogenic instrumentation this...
Neural oscillations mediate the coordination of activity within and between brain networks, supporting cognition behaviour. How these processes develop throughout childhood is not only an important neuroscientific question but could also shed light on mechanisms underlying neurological psychiatric disorders. However, measuring neurodevelopmental trajectory has been hampered by confounds from instrumentation. In this paper, we investigate suitability a disruptive new imaging platform -...
Abstract We demonstrate the first use of Optically Pumped Magnetoencephalography (OP‐MEG) in an epilepsy patient with unrestricted head movement. Current clinical MEG uses a traditional SQUID system, where sensors are cryogenically cooled and housed helmet which patient’s is fixed. Here, we different type sensor (OPM), operates at room temperature can be placed directly on scalp, permitting free performed OP‐MEG recording refractory focal epilepsy. OP‐MEG‐identified analogous interictal...
Abstract Optically pumped magnetometers (OPMs) offer a new wearable means to measure magnetoencephalography (MEG) signals, with many advantages compared conventional systems. However, OPMs are an emerging technology, thus characterizing and replicating MEG recordings is essential. Using OPM-MEG SQUID-MEG, this study investigated evoked responses, oscillatory power, functional connectivity during emotion processing in 20 adults, establish replicability across the two technologies. Five...
Abstract Magnetoencephalography (MEG) measures brain function via assessment of magnetic fields generated by neural currents. Conventional MEG uses superconducting sensors, which place significant limitations on performance, practicality, and deployment; however, the field has been revolutionised in recent years introduction optically-pumped magnetometers (OPMs). OPMs enable measurement signal without cryogenics, consequently conception “OPM-MEG” systems ostensibly allow increased...