A5037692931- Diet and metabolism studies
- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Machine Learning in Healthcare
- Machine Learning in Materials Science
- Meta-analysis and systematic reviews
- Dementia and Cognitive Impairment Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Olfactory and Sensory Function Studies
- Advanced MRI Techniques and Applications
- Heart Rate Variability and Autonomic Control
- Visual perception and processing mechanisms
- Medical Imaging Techniques and Applications
- Neural and Behavioral Psychology Studies
- Sleep and Work-Related Fatigue
- Muscle activation and electromyography studies
- Pain Management and Placebo Effect
- Face Recognition and Perception
- Neurological Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Neurological Disorders and Treatments
- Occupational Health and Performance
Hokuto Hospital
2019-2024
Saitama Prefectural Kumagaya Girls High School
2020-2024
Ricoh (Japan)
2024
University College London
2013-2017
Osaka City University
2008-2015
Czech Academy of Sciences, Institute of Physiology
2012
Fatigue can be classified as mental and physical depending on its cause, each type of fatigue has a multi-factorial nature. We examined the effect central nervous system using electroencephalography (EEG) in eighteen healthy male volunteers.After enrollment, subjects were randomly assigned to two groups single-blinded, crossover fashion perform types fatigue-inducing experiments. Each experiment consisted four 30-min 0- or 2-back test sessions evaluation performed just before after sessions....
Traditional magnetoencephalographic (MEG) brain imaging scanners consist of a rigid sensor array surrounding the head; this means that they are maximally sensitive to superficial structures. New technology based on optical pumping we can now consider more flexible and creative placement. Here explored magnetic fields generated by model human hippocampus not only across scalp but also at roof mouth. We found simulated hippocampal sources gave rise dipolar field patterns with one surface...
It is well accepted that drug transporters play a pivotal role in hepatobiliary excretion of anionic drugs, which drug–drug interactions and genetic polymorphisms are known to cause variations. However, PET probes for vivo functional characterization these have not been established yet. We used investigate hepatic uptake subsequent canalicular efflux <sup>11</sup>C-labeled (15<i>R</i>)-16-<i>m</i>-tolyl-17,18,19,20-tetranorisocarbacyclin methyl ester [(15<i>R</i>)-<sup>11</sup>C-TIC-Me)]...
Abstract Background Fatigue has a multi-factorial nature. We examined the effects of two types mental fatigue on spontaneous oscillatory brain activity using magnetoencephalography (MEG). Methods Participants were randomly assigned to groups in single-blinded, crossover fashion perform fatigue-inducing experiments. Each experiment consisted 30-min 0- or 2-back test session and evaluation sessions performed just before after task session. Results After 0-back test, decreased alpha power was...
Abstract Non-pharmacological treatment (NPT) improves cognitive functions and behavioural disturbances in patients with dementia, but the underlying neural mechanisms are unclear. In this observational study, 21 dementia received NPTs for several months. Patients were scanned using magnetoencephalography twice during NPT period to evaluate effects on resting-state brain activity. Additionally, measured Mini-Mental State Examination (MMSE-J) a short version of Dementia Behaviour Disturbance...
Background Dementia and mild cognitive impairment are characterised by symptoms of decline, which typically assessed using neuropsychological assessments (NPAs), such as the Mini-Mental State Examination (MMSE) Frontal Assessment Battery (FAB). Magnetoencephalography (MEG) is a novel clinical assessment technique that measures brain activities (summarised oscillatory parameters), associated with impairment. However, relevance MEG regional cerebral blood flow (rCBF) data obtained...
Aging and gender influence regional brain activities. Although these biases should be considered during the clinical examinations using magnetoencephalography, they have yet to standardized. In present study, resting-state magnetoencephalography data were recorded from 54 healthy females 48 males aged 22 75 years, who controlled for cognitive performance. The oscillatory power was estimated each frequency band (delta, theta, alpha, beta, low-gamma, high-gamma) sLORETA-like algorithm of age...
Fatigue is a common problem in modern society. We attempted to identify moderate- long-term fatigue-related alterations the central nervous system using cognitive tasks and electroencephalography (EEG) measures. The study group consisted of 17 healthy male participants. After saliva samples were collected measure copy number human herpesvirus (HHV)-6 DNA assess level fatigue, subjects evaluated EEG, with their eyes open for 2 min, then closed 1 min sitting quietly. Thereafter, they completed...
Resting-state neural oscillations are used as biomarkers for functional diseases such dementia, epilepsy, and stroke. However, accurate interpretation of clinical outcomes requires the identification minimisation potential confounding factors. While several studies have indicated that menstrual cycle also alters brain activity, most these were based on visual inspection rather than objective quantitative measures. In present study, we aimed to clarify effect spontaneous...
Abstract Dementia is a syndrome characterised by cognitive impairments, with loss of learning/memory abilities at the earlier stages and executive dysfunction later stages. However, recent studies have suggested that impairments in both functioning might co-exist. Cognitive been primarily evaluated using neuropsychological assessments, such as Mini-Mental State Examination (MMSE). Recently, neuroimaging techniques magnetoencephalography (MEG), which assess changes resting-state brain...
The purpose of this study was to establish a method for imaging the process gastrointestinal (GI) absorption and subsequent biodistribution in human body after oral drug administration, using positron emission tomography (PET) with 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG). First, we developed deliver radiotracer safely into stomach soft gelatin capsules avoid any significant exposure pharyngoesophageal region. Second, performed pharmacokinetic (PK) analyses on time–radioactivity profiles...
The ability to divide one's attention deteriorates in patients with childhood chronic fatigue syndrome (CCFS). We conducted a study using dual verbal task assess allocation of attentional resources two simultaneous activities (picking out vowels and reading for story comprehension) functional magnetic resonance imaging. Patients exhibited much larger area activation, recruiting additional frontal areas. right middle gyrus (MFG), which is included the dorsolateral prefrontal cortex, CCFS was...
Abstract Cognitive impairment is a major concern in clinical medicine. It usually evaluated with neuropsychological assessments, which have inherent limitations. To compensate for them, magnetoencephalography has already come into use to evaluate the level of cognitive impairment. evaluates global changes frequency resting‐state brain activity, are associated status. However, it remains unclear what neural mechanism causes changes. understand this, important identify cortical regions that...
Abstract We used magnetoencephalography ( MEG ) to determine whether increasingly complex forms constituted from the same elements (lines) activate visual cortex with or different latencies. Twenty right‐handed healthy adult volunteers viewed two forms, lines and rhomboids, representing levels of complexity. Our results showed that earliest responses produced by rhomboids in both striate prestriate had similar peak latencies (40 ms) although stronger than rhomboids. Dynamic causal modeling...
Although magnetoencephalography and electroencephalography (M/EEG) signals at sensor level are robust reliable, they suffer from different degrees of distortion due to changes in brain tissue conductivities, known as field spread volume conduction effects. To estimate original neural generators M/EEG activity acquired level, diverse source localisation algorithms have been proposed; however, not exempt limitations usually involve time-consuming procedures. Connectivity network-based analyses...
PurposeEpilepsy is a prevalent neurological disorder characterised by repetitive seizures. It categorised into three types: generalised epilepsy (GE), focal (FE), and combined epilepsy. Correctly subtyping the important to select appropriate treatments. The types are mainly determined (i.e., diagnosed) their semiologies supported clinical examinations, such as electroencephalography magnetoencephalography (MEG). Although these examinations traditionally based on visual inspections of...
We used easily distinguishable stimuli of faces and houses constituted from straight lines, with the aim learning whether they activate V1 on one hand, specialized areas that are critical for processing other, similar latencies. Eighteen subjects took part in experiment, which magnetoencephalography (MEG) coupled to analytical methods detect time course earliest responses these provoke cortical areas. Both categories activated visual cortex outside it at around 40 ms after stimulus onset,...
We here extend and complement our earlier time-based, magneto-encephalographic (MEG), study of the processing forms by visual brain (Shigihara Zeki, 2013) with a functional magnetic resonance imaging (fMRI) study, in order to better localize activity produced early areas when subjects view simple geometric stimuli increasing perceptual complexity (lines, angles, rhomboids) constituted from same elements (lines). Our results show that all three categories form activate which we were...
Our experience and prejudice concerning food play an important role in modulating gustatory information processing; memory stored the central nervous system influences arising from peripheral system. We have elucidated mechanism of "top-down" modulation taste perception humans using functional magnetic resonance imaging (fMRI) demonstrated that imagery is mediated by prefrontal (PFC) insular cortices (IC). However, temporal order activation these brain regions during still open issue. To...