A5068186603- Sleep and related disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Asthma and respiratory diseases
- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Muscle Physiology and Disorders
- Metabolism and Genetic Disorders
- Allergic Rhinitis and Sensitization
- Youth Substance Use and School Attendance
- Food Allergy and Anaphylaxis Research
- Growth Hormone and Insulin-like Growth Factors
- Immune Cell Function and Interaction
- Genetic Neurodegenerative Diseases
- Adipose Tissue and Metabolism
- Glycogen Storage Diseases and Myoclonus
- Psychosomatic Disorders and Their Treatments
- Mitochondrial Function and Pathology
- Virology and Viral Diseases
- Olfactory and Sensory Function Studies
- Diet and metabolism studies
- Neuroscience of respiration and sleep
- Epilepsy research and treatment
- Health, psychology, and well-being
- Stress Responses and Cortisol
- Contact Dermatitis and Allergies
Kumamoto University
2003-2024
Akebono (Japan)
2015-2024
Kobe Central Hospital
2024
Sleep Comprehensive Care Clinic Yoyogi
2010
Kansai Medical University
2005
National Center For Child Health and Development
2001
KU Leuven
2000
National Center of Neurology and Psychiatry
1999
Niigata University
1997
Teikyo University
1997
We investigated whether the abnormal rhythms in infants are related to future development of autism spectrum disorder (ASD), using a questionnaire from September October 2016. The parents 160 children with ASD (male, n = 123; female, 37) were recruited two hospitals K and H cities, as control group, 145 75; 70) four nursery schools T city. associations between bedtime waking time on weekdays weekends infancy (<1 years age), at 1–3 years, 3–5 ages studied multivariable logistic regression...
We describe 2 cases in whom systemic anaphylaxis developed shortly after they had eaten food contaminated by a storage mite, Tyrophagus putresceniiae. were able to demonstrate that these sensitive the mites but not allergens, leading us conclude cases' anaphylactic episodes result of ingestion mites. This is first report causing persons.
To elucidate how the size of expanded CAG repeat gene for dentatorubral pallidoluysian atrophy (DRPLA) and other factors affect brainstem cerebellum, appearance high-intensity signals on T2-weighted MRI cerebral white matter patients with DRPLA, we quantitatively analyzed findings 26 diagnosis which was confirmed by molecular analysis DRPLA gene. When classified into two groups based (group 1, number units > or = 66; group 2, < 65), found strong inverse correlations between age at areas...
Serum levels of IL-8 were determined in HIV-infected individuals and the results compared with those for HIV- controls. The measured by an ELISA a MoAb polyclonal antibody to recombinant IL-8. means 95% confidence intervals sera 36 32 matched controls 275 216-349 pg/ml, 8 4-14 respectively, showing 34-fold increase circulation individuals. This does not appear be related disease state, infection or systemic medical agents. finding suggests possible involvement pathogenesis HIV-induced disease.
SUMMARY The serum levels of soluble IL-2 receptor (sIL-2R), IL-4 and IgE-binding factors were examined in children with allergic diseases, compared those non-allergic controls the same age sex. results showed age-related decreases sIL-2R factors, but not that both individuals. Significant elevation was observed sera from atopic eczema or history an anaphylactic reaction to food, as controls. concentration elevated all groups, including cases eczema, bronchial asthma anaphylaxis controls,...
Proteome analysis using human serum is a technological advancement that will enable the discovery of novel biomarkers and biomarker patterns various diseases. Although proteome has potential in disease prevention, early diagnosis treatment diseases, evaluation pharmacotherapies, this technology still its infancy. Thus, we sought to develop an advanced method conducting on serum. In study, report development semi-comprehensive protein analytical technique, which involves systematic use iTRAQ...
In recent years, circadian rhythm sleep disorders in humans have been increasing. Clinical features characteristic of this disorder are well known, but the specific causes remain unknown. However, various derangements expression clock gene a probable cause disease. We attempted to elucidate relationship between genes whole blood cells and clinical disorder. study, we indicate daily period (Per) 1, 2, 3, Bmal1, Clock 12 healthy male subjects. The peak phase Per1, Per2, Per3 appeared early...
In the present study, reliability and construct validity of Japanese version Chalder Fatigue Scale was evaluated as a measure severity fatigue among young students in Japan. A healthy group comprised 27 Grade 6 primary school 28 1 junior high students. The severely fatigued were hospital outpatients with childhood chronic syndrome (n = 21). Principal components analysis varimax rotation identified 4 factors which accounted for 63.2% total variance, original English version. Internal...
Summary This study was performed to determine whether or not IL-18, formerly called IFN-γ-inducing factor, is involved in the pathogeneses of allergic disorders. Peripheral blood mononuclear cells (PBMC) were obtained from patients with bronchial asthma (BA), atopic dermatitis (AD) and controls who did have any disease, then cultured lipopolysaccharide (LPS) phytohaemagglutinin (PHA). The concentrations IFN-γ IL-13 supernatant fluids determined by enzymatic immunoassaying, expression...
We examined relationships among fatigue, sleep quality, and effort-reward imbalance for learning in school children. developed an scale students its reliability validity. Self-administered surveys, including the effort reward leaning fatigue scale, were completed by 1,023 elementary (grades 4-6) 1,361 junior high 7-9) at end of 2006. Effort-reward was associated with a incidence problems both genders. A good relationship family low score boys, friends girls multiple regression analysis....
A 19-month-old girl with moderate hypotonia was studied. Histochemical and electronmicroscopic findings revealed that many skeletal muscle fibers contained an excess amount of glycogen. The phosphorylase reaction normalized only after activation 5' AMP. Biochemical studies showed increased glycogen content decreased activities "a" active form kinase, whereas total phosphorylase, cyclic AMP-dependent protein kinase were all in the normal range. Thus, patient's seemed to be a variant form,...
The ability to divide one's attention deteriorates in patients with childhood chronic fatigue syndrome (CCFS). We conducted a study using dual verbal task assess allocation of attentional resources two simultaneous activities (picking out vowels and reading for story comprehension) functional magnetic resonance imaging. Patients exhibited much larger area activation, recruiting additional frontal areas. right middle gyrus (MFG), which is included the dorsolateral prefrontal cortex, CCFS was...
Sleep deprivation and circadian disruption are associated with decreased insulin sensitivity hyperglycemia. It is uncertain whether sleep-wake disorder (CRSWD), which relates to both the homeostatic sleep system timing system, affects glycemic regulation secretion. We aimed examine associations among duration, architecture or rhythm of cycle, glucose metabolism in children, adolescents, young adults CRSWD.This cross-sectional observational study 124 patients CRSWD took place at Hyogo...
Recently, it has been suggested that sleep problems in autism spectrum disorder (ASD) not only are associated symptoms, but may be deeply related to ASD pathogenesis. Common clinical practice relating developmental disorders, shown parents of children with have often stated is more difficult raise the neonatal period because these exhibit problems. This study investigated possibility abnormal sleep-wake rhythms future development. We administered questionnaires assess parent(s) and controls....
ABSTRACT Two patients with subacute sclerosing panencephalitis (SSPE) were treated safely and effectively high doses of intravenous ribavirin combined intraventricular alpha interferon. The concentrations maintained in the serum cerebrospinal fluid higher than those which inhibit SSPE virus replication vitro vivo.
In order to assess the cardiovascular autonomic nervous functions in patients with fetal type Minamata disease (FMD), we investigated blood pressure (BP), and conducted time frequency domain analysis of heart rate variability (HRV). Subjects were 9 Meisuien recognized as FMD, 13 healthy age matched control subjects. HRV BP assessed after subjects rested a supine position for 10 minutes. Electrocardiographic (ECG) data collected 3 minutes during natural breathing. Time (the average R-R...