A5047853106- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Dementia and Cognitive Impairment Research
- Neurobiology of Language and Bilingualism
- Amyotrophic Lateral Sclerosis Research
- Transcranial Magnetic Stimulation Studies
- Health Systems, Economic Evaluations, Quality of Life
- Genetic Neurodegenerative Diseases
- Cognitive Functions and Memory
- Frailty in Older Adults
- Neurogenetic and Muscular Disorders Research
- Autism Spectrum Disorder Research
- Attention Deficit Hyperactivity Disorder
- Advanced Neuroimaging Techniques and Applications
- Epilepsy research and treatment
- Technology Use by Older Adults
- Nutrition and Health in Aging
- Context-Aware Activity Recognition Systems
- Traumatic Brain Injury Research
- Alzheimer's disease research and treatments
- Mental Health and Psychiatry
- Restless Legs Syndrome Research
- Balance, Gait, and Falls Prevention
- Stroke Rehabilitation and Recovery
- Pharmaceutical Practices and Patient Outcomes
Baylor College of Medicine
2016-2025
University of Iowa
2024
Rutgers, The State University of New Jersey
2024
University of Pennsylvania
2024
Michael E. DeBakey VA Medical Center
2008-2022
Center for Innovation
2022
Amyotrophic Lateral Sclerosis Association
2010-2018
Baylor School
2012
Seoul Veterans Hospital
2012
Veterans Health Administration
2011
Background: Parkinson’s disease (PD) is a complex neurodegenerative disorder impacting everyday function and quality of life. Rehabilitation plays crucial role in improving symptoms, function, life reducing disability, particularly given the lack disease-modifying agents limitations medications surgical therapies. However, rehabilitative care under-recognized under-utilized PD often only utilized later stages, despite research guidelines demonstrating its positive effects. Currently, there...
Up to half of patients with ALS develop cognitive impairment during the course illness. Despite this, there is no simple tool for screening in clinical setting. This study examines sensitivity, specificity and accuracy Cognitive Behavioral Screen (ALS-CBS™). We administered measure 112 patients, including 31 who also underwent comprehensive neuropsychological testing. results were validated by determining against full battery. Optimal cut-off scores predicting correct diagnosis determined,...
We investigated the cognitive and psychiatric outcome 6 months after bilateral subthalamic nucleus deep brain stimulation (DBS) for treatment of Parkinson's disease (PD) using a control group.23 patients who underwent DBS were compared with 28 medically treated PD at baseline neuropsychological measures. In addition to group outcomes, we report reliable change indices (RCI) dementia caseness analysis.Patients demonstrated significant decline in verbal memory (p<0.003), trends on oral...
Our objective was to test the hypothesis that changes in body mass index (BMI) are associated with clinical course of ALS. We examined relationships between BMI at first visit and up a two-year follow-up, multiple variables related ALS: age onset, rate progression motor symptoms, survival. Baseline classified according World Health Organization (WHO) criteria. Changes were as loss >1 unit, no change, or gain unit. results showed baseline not In contrast, over two years significantly shorter...
<h3>Background</h3> Deep brain stimulation (DBS) improves motor symptoms in Parkinson9s disease (PD), but questions remain regarding neuropsychological decrements sometimes associated with this treatment, including rates of statistically and clinically meaningful change, whether there are differences outcome related to surgical target. <h3>Methods</h3> Neuropsychological functioning was assessed patients (PD) at baseline after 6 months a prospective, randomised, controlled study comparing...
Background: Social isolation during COVID-19 may negatively impact older adults’ wellbeing. To assess its impact, we measured changes in physical activity and sleep among community-dwelling adults, from pre-to post-pandemic declaration. Method: Physical adults (n = 10, age 77.3 ± 1.9 years, female 40%) were remotely assessed within 3-month 6-month declaration using a pendant-wearable system. Depression was pre-and the Center for Epidemiologic Studies scale compared with 48 h continuous...
It is widely cited that dementia occurs in up to 80% of patients with Parkinson disease (PD), but studies reporting such high rates were published over two decades ago, had relatively small samples, and other limitations. We aimed determine long-term risk PD using data from large, ongoing, prospective, observational studies.
Anxiety and depression often remain unrecognized or inadequately treated in patients with Parkinson disease (PD). Cognitive–behavioral therapy (CBT) is effective, but limited evidence supports its use for anxiety PD. Sixteen PD having significant and/or depressive symptoms were assigned to CBT enhanced usual care. Assessments occurred at baseline, posttreatment, 1-month follow-up. The intervention included tools anxiety, depression, healthy living symptoms. Individual sessions delivered by...
To determine the evolution of numerous neuropsychiatric symptoms and cognitive abilities in Parkinson disease from onset.
We evaluated the safety and efficacy of microelectrode-guided stereotactic pallidotomy in patients with advanced Parkinson9s disease (PD). Using diagnostic criteria evaluations outlined Core Assessment Programme Transplantation (CAPIT) protocol, we studied unilateral 26 idiophatic PD, motor fluctuations, peak dose dyskinesias. All underwent pallidotomy. Assessments conducted "practically defined off" "best on" states at baseline 1 6 months postoperatively included Unified Disease Rating...
Several metabolic derangements associated with diabetes mellitus type 2 (DM) have been a better outcome in amyotrophic lateral sclerosis (ALS), including hyperlipidemia and obesity. Here, we tested the hypothesis that DM would positive effect on motor cognitive findings of ALS.We compared data from ALS patients pre-morbid (ALS-DM; n = 175) versus without (ALS; 2196) regard to age onset, rate progression, survival, neuropsychological test performance.The onset was later for women, Caucasians...
Background and purpose: Subthalamic nucleus deep brain stimulation (STN‐DBS) has been shown to have beneficial effects on the motor features of Parkinson’s disease (PD), but its impact non‐motor symptoms, most notably mood, not fully explored. Methods: In first study independently compare emotional‐cognitive somatic/physiological symptoms depression, we examined mood differences in 17 bilateral STN‐DBS 22 matched non‐surgical PD patients at baseline 6 months. Results: The group reported...
Cognitive dysfunction in Parkinson's disease contributes to disability, caregiver strain, and diminished quality of life. rehabilitation, a behavioral approach improve cognitive skills, has potential as treatment option maintain skills increase life for those with disease-related dysfunction. Four rehabilitation programs individuals PD are identified from the literature. Characteristics outcomes reviewed critiqued. Current studies on demonstrate feasibility acceptability program patients PD,...
Cognitive frailty (CF), defined as the simultaneous presence of cognitive impairment and physical frailty, is a clinical symptom in early-stage dementia with promise assessing risk dementia. The purpose this study was to use wearables determine most sensitive digital gait biomarkers identify CF.Of 121 older adults (age = 78.9 ± 8.2 years, body mass index 26.6 5.5 kg/m2) who were evaluated comprehensive neurological exam Fried criteria, 41 participants (34%) identified CF 80 (66%) without CF....
Abstract Background Cognitive impairment is common at all stages of Parkinson's disease (PD), but there no consensus on which neuropsychological tests to use or how interpret cognitive battery results. A summary score (CSS) combines the richness a with simplicity single score. Objective The objective this study was determine whether CSS created using robust norming can detect early deficits in de novo, untreated PD. Methods Baseline data from PD participants and healthy control (HCs)...
Objective: To evaluate the role of neurocognitive impairment on retention in care across lifespan antiretroviral-naïve persons newly diagnosed with HIV. Design: A prospective observational study 138 antiretroviral-naive HIV-positive participants who presented to an urban clinic between August 2010 and April 2013. Methods: All underwent a baseline evaluation that included neuromedical examination brief neuropsychological test battery. Retention was operationalized as attending at least two...
Assessment of instrumental activities daily living (IADL) is essential for the diagnosis and staging dementia. However, current IADL assessments are subjective cannot be administered remotely. We proposed a smart-home design, called IADLSys, remote monitoring IADL. IADLSys consists three major components: (1) wireless physical tags (pTAG) attached to objects interest, (2) pendant-sensor monitor detect interaction with pTAGs, (3) an interactive tablet as gateway transfer data secured cloud....
Improved life expectancy is increasing the number of older adults who suffer from motor-cognitive decline. Unfortunately, conventional balance exercise programs are not tailored to patients with cognitive impairments, and adherence often poor due unsupervised settings. This study describes acceptability feasibility a sensor-based in-home interactive system, called tele-Exergame, used by mild impairment (MCI) or dementia. Our tele-Exergame specifically designed improve cognition during...