A5008904738- Parkinson's Disease Mechanisms and Treatments
- Balance, Gait, and Falls Prevention
- Cerebral Palsy and Movement Disorders
- Neurological disorders and treatments
- Muscle activation and electromyography studies
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Botulinum Toxin and Related Neurological Disorders
- Autism Spectrum Disorder Research
- Genetic Neurodegenerative Diseases
- Pain Management and Treatment
- Mitochondrial Function and Pathology
- Stroke Rehabilitation and Recovery
- Histone Deacetylase Inhibitors Research
- Glycogen Storage Diseases and Myoclonus
- Medication Adherence and Compliance
- Neuroscience and Neuropharmacology Research
- Pharmaceutical Practices and Patient Outcomes
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Transcranial Magnetic Stimulation Studies
- Children's Physical and Motor Development
- Dementia and Cognitive Impairment Research
- Voice and Speech Disorders
- Infant Health and Development
Lehigh Valley Hospital-Pocono
2014-2018
Lehigh Valley Health Network
2014-2018
University of South Florida
2018
Baylor College of Medicine
2001-2015
Michael E. DeBakey VA Medical Center
2011-2015
Swedish Civil Contingencies Agency
2015
Ralph Lauren Center for Cancer Care and Prevention
2015
Icahn School of Medicine at Mount Sinai
1996-1997
The Graduate Center, CUNY
1996
<h3>Objectives:</h3> Our objective was to compare long-term outcomes of deep brain stimulation (DBS) the globus pallidus interna (GPi) and subthalamic nucleus (STN) for patients with Parkinson disease (PD) in a multicenter randomized controlled trial. <h3>Methods:</h3> Patients randomly assigned GPi (n = 89) or STN DBS 70) were followed 36 months. The primary outcome motor function on stimulation/off medication using Unified Parkinson9s Disease Rating Scale subscale. Secondary included...
Studies have demonstrated strong associations between the prone sleep position (on stomach) and sudden infant death syndrome (SIDS). In 1992, American Academy of Pediatrics recommended that infants be placed to laterally their side) or supine back) reduce SIDS risk, in 1994, national public education campaign "Back Sleep" was launched.To determine typical younger than 8 months United States, changes occurred after these recommendations, factors associated with placement supine.Annual...
The effect of glial cell line-derived neurotrophic factor (GDNF) on the growth mesencephalic dopaminergic neurons and their survival following exposure to neurotoxin 1-methyl-4-phenylpyridinium (MPP+) was examined in vitro. In cultures developing under normal conditions, GDNF at 1 ng/ml optimally improved stimulated without affecting growth. treated with MPP+, could not prevent toxicity neurons. uptake [3H]dopamine number tyrosine hydroxylase-positive were similarly reduced by MPP+ presence...
Objectives: To study the effects of levodopa and walking speed on gait variability in individuals with Parkinson's disease (PD). Methods: Thirty-three PD were studied. Their mean age was 70·61±9·23 year. The average time since diagnosis 9·65±5·80 Gait studied while 'OFF' 'ON' dopaminergic medication when subjects walked at their usual fastest speeds. Results: Variability step time, double support stride length velocity decreased significantly (P=0·037; P=0·037; P=0·022; P=0·043,...
To investigate the relationships between falls, fear of falling, and activity limitations in individuals with Parkinson's disease (PD).Cross-sectional study mild to moderate PD (N = 83). Associations among demographic data, fall frequency, severity, motor impairment, ability perform activities daily living (ADL), Activities Balance Confidence Scale, Iowa Fatigue Comorbidity Index, Physical Activity Scale for Elders were studied.Frequent fallers had more ADL than nonfallers (p < .001) rare...
Abstract: Neurotrophic factors have been shown to support the survival and promote recovery of injured neurons both in vivo vitro. Here, we investigated whether glial cell line‐derived neurotrophic factor (GDNF) basic fibroblast growth (bFGF) could modify damage dopamine (DA) mesencephalic cultures caused by neurotoxin 6‐hydroxydopamine (6‐OHDA). The data show that bFGF, but not GDNF, effectively protected DA from 6‐OHDA toxicity. Because bFGF is a mitogen, whereas GDNF not, tested cells...
Background Levodopa treatment has been shown to improve gait spatio-temporal characteristics in both forward and backward walking. However, effect of levodopa on variability during walking compared with not reported. Aims study To the effects individuals Parkinson's disease (PD). Methods Forty PD were studied. Their mean age was 68.70 ± 7.46 year. The average time since diagnosis 9.41 5.72 Gait studied while 'OFF' 'ON' when participants walked at their usual speed. Variability step time,...
The objective of this study was to investigate the relationships between motor symptoms Parkinson disease (PD) and activity limitations in persons with PD.This is a cross-sectional mild moderate PD (N = 90). Associations among axial features, limb signs, Physical Activity Scale for Elderly, ability perform Activities Daily Living (ADLs), level ADL dependency were studied. A composite score features included following Unified Disease Rating items: speech, rigidity neck, arising from chair,...
Abstract Background Treadmill training has been shown to be a promising rehabilitation strategy for improving gait and balance in persons with Parkinson disease (PD). Most studies have involved only forward walking as an intervention. The effects of multidirectional treadmill (forward, backward, left right sideways) on not reported. Objective To investigate the acute long‐term (MDTT) PD, determine optimal duration. Design Single group, repeated‐measures design. Setting Research laboratory...
Aim: To investigate the relationships between falls, fear of falling, and activity limitations in individuals with Parkinson's disease (PD). Design/methods: Cross-sectional study mild to moderate PD (N = 83). Associations among demographic data, fall frequency, severity, motor impairment, ability perform activities daily living (ADL), Activities Balance Confidence Scale, Iowa Fatigue Comorbidity Index, Physical Activity Scale for Elders were studied. Results: Frequent fallers had more ADL...
Abstract: Parkinson's disease (PD) is a progressive neurological disorder that primarily affects older adults. The number of patients who receive specialty care continues to be limited, even though the benefits seeing movement specialist for management PD have been well established. Telemedicine has suggested as useful tool in addressing problem access care. As evidenced by literature, it using telemedicine treat feasible and economically advantageous both providers. A high level interest...
Parkinson’s disease (PD) is a progressive, neurodegenerative disease, but responses to exercise tests with different severity have not been investigated. PURPOSE: To examine whether cardiovascular treadmill differed among persons PD who severity. METHODS: A retrospective review of the results from 41 underwent symptom limited test using modified Bruce protocol. Thirty (73.2%) subjects were male and 11 female (26.8%). The average age was 69.1 year duration 7.9 years. Fourteen in Hoehn Yahr...
Objective: This study is to test the reliability and validity of an overground walk in patients with Parkinson9s disease (PD). Background The gait has been used extensively functional ability measure progress various neurological deficits. It refers physical therapists9 observation cuing patient9s walking pattern. In effort make easier administer, some conduct this on speed-adjustable apparatus. modification compared traditional electronic walkway had not studied PD. Design/Methods: Thirty...