A5077326850- Cerebral Palsy and Movement Disorders
- Muscle activation and electromyography studies
- Neonatal and fetal brain pathology
- EEG and Brain-Computer Interfaces
- Balance, Gait, and Falls Prevention
- Botulinum Toxin and Related Neurological Disorders
- Motor Control and Adaptation
- Stroke Rehabilitation and Recovery
- Neural dynamics and brain function
- Infant Development and Preterm Care
- Robotic Locomotion and Control
- Lower Extremity Biomechanics and Pathologies
- Children's Physical and Motor Development
- Functional Brain Connectivity Studies
- Spinal Cord Injury Research
- Tactile and Sensory Interactions
- Sports injuries and prevention
- Parkinson's Disease Mechanisms and Treatments
- Multiple Sclerosis Research Studies
- Neuroscience and Neural Engineering
- Transcranial Magnetic Stimulation Studies
- Bat Biology and Ecology Studies
- Effects of Vibration on Health
- Sports Dynamics and Biomechanics
- Neurological disorders and treatments
Boys Town National Research Hospital
2020-2024
Boys Town
2020-2024
Creighton University
2022-2024
HumanN (United States)
2024
University of Stuttgart
2021
Nebraska Medical Center
2011-2020
University of Nebraska Medical Center
2011-2020
Meyer (China)
2018
American Association of University Women
2018
World Bank
2018
Abstract Background Animal models of Parkinson's disease have been widely used for investigating the mechanisms neurodegenerative process and discovering alternative strategies treating disease. Following 10 injections with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 25 mg/kg) probenecid (250 over 5 weeks in mice, we established characterized a chronic mouse model (MPD), which displays severe long-term neurological pathological defects resembling that human advanced stage. The...
In the largest and most expansive lifespan magnetoencephalography (MEG) study to date (n = 434, 6 84 y), we provide critical data on normative trajectory of resting-state spontaneous activity its temporal dynamics. We perform cutting-edge analyses examine age sex effects whole-brain, spatially-resolved relative absolute power maps, find significant in all spectral bands both types maps. Specifically, lower frequencies showed a negative correlation with age, while higher positively correlated...
Aim This investigation used magnetoencephalography ( MEG ) to examine the neural oscillatory responses of sensorimotor cortices during motor planning and movement execution stages children with typical development cerebral palsy CP ). Method The study involved 13 (nine males, four females; mean [ SD ] age 14y 3mo [9mo], range 10–18y; height 1.61m [0.08m]; weight 52.65kg [13kg]), age‐ sex‐matched typically developing (height 1.64m [0.06m]; 56.88kg [10kg]). experiment required extend their...
Parkinson's disease (PD) is a progressive debilitating neurodegenerative disorder clinically manifest by motor, posture and gait abnormalities. Human neurophysiological studies recording local field potentials within the subthalamic nucleus scalp-based electroencephalography have shown pathological beta synchrony throughout basal ganglia-thalamic-cortical motor network in PD. Notably, suppression of this dopamine replacement therapy or deep-brain stimulation has been associated with improved...
Cerebral palsy (CP) results from a perinatal brain injury that often in sensory impairments and greater errors motor performance. Although these have been well catalogued, the relationship between processing networks performance has not explored. Children with CP typically developing age-matched controls participated this investigation. We used high-density magnetoencephalography to measure event-related oscillatory changes somatosensory cortices following tactile stimulation bottom of foot....
The noted disruption of thalamocortical connections and abnormalities in tactile sensory function has resulted a new definition cerebral palsy (CP) that recognizes the sensorimotor integration process as central to motor impairments seen these children. Despite this updated definition, connection between child's somatosensory processing remains almost entirely unknown. In investigation, we explored relationship magnitude neural activity within cortices, strength ankle plantarflexors, gait...
We currently have a substantial knowledge gap in our understanding of the neurophysiological underpinnings sensory perception deficits often reported clinic for children with cerebral palsy (CP). In this investigation, we begun to address by using magnetoencephalography (MEG) brain imaging evaluate gating neural oscillations somatosensory cortices. A cohort CP (Gross Motor Function Classification System II-III) and typically developing underwent paired-pulse electrical stimulation tibial...
In Brief Purpose: To examine the feasibility of using lower body positive pressure supported (LBPPS) treadmill training to improve walking abilities, balance and extremity strength children with cerebral palsy (CP). Methods: Nine CP (GMFCS II-IV) participated in LBPPS 2 days per week for 6 weeks. Pre post measures preferred speed, spatiotemporal kinematics, strength, BESTest were used assess potential improvements from training. Results: resulted significantly faster less time double...
Sensory gating is important for preventing excessive environmental stimulation from overloading neural resources. Gating in the human somatosensory cortices a critically understudied topic, particularly lower extremities. We utilize unique capabilities of magnetoencephalographic neuroimaging to quantify normative population responses and dynamic functional connectivity extremities healthy participants. show that processing subserved by robust effect oscillatory domain, as well on...
This study investigated intralimb coordination during walking in young and elderly women using the theoretical model of dynamical systems. 20 women, 10 Young (M age=24.6 yr., SD= 3.2 yr.) Elderly age=73.7 SD=4.9 yr.), were videotaped free speed gait perturbed by an ankle weight. Two parameters, one describing phasing relationship between segments (mean absolute relative phase) other variability this (deviation phase), calculated from kinematics. Two-way analysis variance (age weight) with...
The neuroimaging literature on cerebral palsy (CP) has predominantly focused identifying structural aberrations within the white matter (e.g., fiber track integrity), with very few studies examining neural activity key networks that serve production of motor actions. current investigation used high-density magnetoencephalography to begin fill this knowledge gap by quantifying temporal dynamics alpha and beta cortical oscillations in children CP (age = 15.5 ± 3 years; GMFCS levels II–III)...