A5103081947- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Disease and Adiposity
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Mechanical Circulatory Support Devices
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac Arrhythmias and Treatments
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Adipose Tissue and Metabolism
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Antimicrobial Resistance in Staphylococcus
- Cardiovascular Function and Risk Factors
- Transplantation: Methods and Outcomes
- Cardiac tumors and thrombi
- Atrial Fibrillation Management and Outcomes
- Streptococcal Infections and Treatments
- Pericarditis and Cardiac Tamponade
- Cardiac and Coronary Surgery Techniques
- Congenital Heart Disease Studies
- Historical and socio-economic studies of Spain and related regions
- Aortic aneurysm repair treatments
- Archaeological and Historical Studies
- Cardiovascular Effects of Exercise
Complejo Hospitalario Universitario de Santiago
2016-2025
Universidade de Santiago de Compostela
2015-2024
Complexo Hospitalario Universitario A Coruña
2019-2024
Center of Regenerative Medicine in Barcelona
2024
Universitat de Barcelona
2024
Institut d'Investigació Biomédica de Bellvitge
2024
Universitat Pompeu Fabra
2024
Hospital Regional de Alta Especialidad del Bajío
2024
Hospital Clínico Universitario Virgen de la Victoria
2024
Centro de Investigación en Red en Enfermedades Cardiovasculares
2017-2023
Abstract Background Obesity has increased in recent years with consequences on diabetes and other comorbidities. Thus, 1 out of 3 diabetic patients suffers cardiovascular disease (CVD). The network among glucose, immune system, endothelium epicardial fat an important role pro-inflammatory thrombotic mechanisms atherogenesis. Since semaglutide, long-acting glucagon like peptide 1- receptor agonist (GLP-1-RA), a glucose-lowering drug, reduces body weight, we aimed to study its effects human...
Abstract Aims In patients with cardiovascular disease, epicardial adipose tissue (EAT) is characterized by insulin resistance, high pro-inflammatory chemokines, and low differentiation ability. As dapagliflozin reduces body fat events in diabetic patients, we would like to know its effect on EAT subcutaneous (SAT). Methods results Adipose samples were obtained from 52 undergoing heart surgery. Sodium-glucose cotransporter 2 (SGLT2) expression was determined real-time polymerase chain...
Epicardial adipose tissue (EAT) is an endocrine organ adjacent to coronary arteries and myocardium without anatomy barriers. Locally produced adipokines may reflect or affect cardiovascular physiology pathology. Our aim was study the protein expression profiles of EAT subcutaneous (SAT) identify local candidate molecules characterizing in patients with disease. SAT samples were collected from 55 undergoing heart surgery. Proteins these tissues separated by two-dimensional (2D) gel...
Objectives: To study the effects of levodopa and walking speed on gait variability in individuals with Parkinson's disease (PD). Methods: Thirty-three PD were studied. Their mean age was 70·61±9·23 year. The average time since diagnosis 9·65±5·80 Gait studied while 'OFF' 'ON' dopaminergic medication when subjects walked at their usual fastest speeds. Results: Variability step time, double support stride length velocity decreased significantly (P=0·037; P=0·037; P=0·022; P=0·043,...
The functional unit molecular size of the intestinal brush border membrane-bound Na+/glucose cotransporter was determined by radiation inactivation. Purified membrane vesicles preserved in cryoprotectant buffer were irradiated (-135 degrees C) with high-energy electrons from a 13-MeV (1 eV = 1.602 x 10(-19) J) linear accelerator at doses 0 to 70 Mrad rad 0.01 Gy). After each dose, investigated respect (i) Na(+)-dependent transport activity and (ii) immunologic blot analysis antibodies...
Abstract Background Carbohydrate antigen 125 (CA125) is a proteolytic fragment of MUC-16 that increased in heart failure (HF) and associated with inflammation, fluid overload, worse adverse events. Our main objective was to study the expression CA125 on epicardium its association adipogenesis, fibrosis. Methods Epicardial fat biopsies blood were obtained from 151 non-selected patients undergoing open surgery. Immunohistochemistry, ELISA, or real-time PCR used for analyzing protein mRNA...
Objective: To determine if preoperative statin treatment is associated with a reduction in systemic inflammatory response (SIR) and myocardial damage markers following cardiac surgery cardiopulmonary bypass (CPB). Methods: We study prospective cohort of 138 patients who underwent coronary valvular CPB. differentiate two groups: (group A, n = 72) or without B, 66) statins. Plasma levels pro-inflammatory interleukins (tumour necrosis factor-alpha (TNF-α), interleukin (IL)-6, IL-8 IL-2R),...
Abstract Aims Obesity, diabetes and cardiovascular disease are associated with COVID‐19 risk severity. Because epicardial adipose tissue (EAT) expresses ACE2, we wanted to identify the main factors ACE2 levels its cleavage enzyme, ADAM17, in fat. Materials methods Epicardial subcutaneous fat biopsies were obtained from 43 patients who underwent open‐heart surgery. From 36 patients, used for RNA expression analysis by real‐time PCR of ACE1, ADAM17 . 8 stromal vascular cells submitted...
Background: High thoracic epidural techniques are increasingly being used in patients scheduled for cardiothoracic surgery, including coronary artery bypass grafting. In the present study, we evaluated acute effects of blockade on myocardial oxygen availability by means tissue pressure monitoring submitted surgical revascularization. Methods: Fifty adult were included a prospective, randomized, double‐blind study. After placement an catheter space T1–T2, and under general anesthesia, 5–10 ml...
<b><i>Objective:</i></b> To characterize non-motor symptoms in individuals with Parkinson’s disease (PD) who experience falls compared to those do not fall. <b><i>Methods:</i></b> Fifty-four PD were studied. Thirty-six fallers and 18 non-fallers. Fatigue was assessed by the Iowa Scale. Excessive daytime sleepiness Epworth Sleepiness Scale, depressive symptomatology short-form Center for Epidemiologic Studies Depression...
The thickness of epicardial adipose tissue (EAT), which is an inflammatory source for coronary artery disease (CAD), correlates with insulin resistance. One trigger factor impaired adipogenesis. Here, our aim was to clarify the underlying mechanisms resistance on EAT-mesenchymal cells (MC). EAT and subcutaneous (SAT) were collected from 19 patients who undergoing heart surgery. Their dedifferentiated adipocytes (DAs) and/or MCs cultured. After induction adipogenesis or stimulation insulin,...