A5049361072- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Diabetes Treatment and Management
- Cardiovascular Effects of Exercise
- Regulation of Appetite and Obesity
- Atherosclerosis and Cardiovascular Diseases
- GDF15 and Related Biomarkers
- Neuroendocrine Tumor Research Advances
- Cardiomyopathy and Myosin Studies
- Biomarkers in Disease Mechanisms
- Biochemical Analysis and Sensing Techniques
- Vitamin C and Antioxidants Research
- Cardiac Imaging and Diagnostics
- Cardiac and Coronary Surgery Techniques
- COVID-19 Clinical Research Studies
- Metabolism, Diabetes, and Cancer
- Advanced Glycation End Products research
- Circular RNAs in diseases
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
Instituto de Salud Carlos III
2020-2025
Centro de Investigación Biomédica en Red
2018-2025
Universidade de Santiago de Compostela
2000-2025
Complejo Hospitalario Universitario de Santiago
2004-2025
Complexo Hospitalario Universitario A Coruña
2017-2025
Instituto de Investigación Sanitaria de Santiago
2014-2024
Centro de Investigación en Red en Enfermedades Cardiovasculares
2017-2024
Servicio Gallego de Salud
2017-2023
Amsterdam UMC Location Vrije Universiteit Amsterdam
2005-2006
Adiponectin is thought to play a decisive role in the relationships among obesity, insulin resistance and cardiovascular risk. This study investigated whether cardiomyocytes synthesize secrete adiponectin, effects of this hormone on cardiac cells. RT‐PCR showed that mouse, rat human produced mRNA for adiponectin receptors 1 2. Immunohistochemistry confirmed presence cytoplasm cultured cardiomyocytes, radioimmunoassay these cells secreted into culture medium. Exogenous enhanced glucose fatty...
Abstract Background Obesity has increased in recent years with consequences on diabetes and other comorbidities. Thus, 1 out of 3 diabetic patients suffers cardiovascular disease (CVD). The network among glucose, immune system, endothelium epicardial fat an important role pro-inflammatory thrombotic mechanisms atherogenesis. Since semaglutide, long-acting glucagon like peptide 1- receptor agonist (GLP-1-RA), a glucose-lowering drug, reduces body weight, we aimed to study its effects human...
Abstract Aims In patients with cardiovascular disease, epicardial adipose tissue (EAT) is characterized by insulin resistance, high pro-inflammatory chemokines, and low differentiation ability. As dapagliflozin reduces body fat events in diabetic patients, we would like to know its effect on EAT subcutaneous (SAT). Methods results Adipose samples were obtained from 52 undergoing heart surgery. Sodium-glucose cotransporter 2 (SGLT2) expression was determined real-time polymerase chain...
Epicardial adipose tissue (EAT) is an endocrine organ adjacent to coronary arteries and myocardium without anatomy barriers. Locally produced adipokines may reflect or affect cardiovascular physiology pathology. Our aim was study the protein expression profiles of EAT subcutaneous (SAT) identify local candidate molecules characterizing in patients with disease. SAT samples were collected from 55 undergoing heart surgery. Proteins these tissues separated by two-dimensional (2D) gel...
Abstract Background and Aims Meteorin‐like protein (Metrnl) has been recently suggested as a new adipokine with protective cardiovascular effects. Its circulating levels in patients seem to be associated heart failure (HF), although contradictory results. Our aim was ascertain whether this could estimate the prognosis of HF de novo (DNHF) patients. Methods Metrnl plasma 400 hospitalized DNHF (55% reduced ejection fraction, 17.3% mid‐range 27.8% preserved fraction) were measured by...
Retinol-binding protein 4 (RBP4), produced by adipocytes and hepatocytes, contributes to an unfavourable lipid profile insulin resistance, which can contribute the development of coronary artery disease (CAD). Recently, several studies have shown that epicardial adipose tissue (EAT) differs from subcutaneous (SAT) plays a role on physiopathology CAD because its proximity arteries. We aimed study expression secretion levels RBP4 in both fat tissues explore possible association with...
Abstract Aims Obesity, diabetes and cardiovascular disease are associated with COVID‐19 risk severity. Because epicardial adipose tissue (EAT) expresses ACE2, we wanted to identify the main factors ACE2 levels its cleavage enzyme, ADAM17, in fat. Materials methods Epicardial subcutaneous fat biopsies were obtained from 43 patients who underwent open‐heart surgery. From 36 patients, used for RNA expression analysis by real‐time PCR of ACE1, ADAM17 . 8 stromal vascular cells submitted...
Abstract Background Carbohydrate antigen 125 (CA125) is a proteolytic fragment of MUC-16 that increased in heart failure (HF) and associated with inflammation, fluid overload, worse adverse events. Our main objective was to study the expression CA125 on epicardium its association adipogenesis, fibrosis. Methods Epicardial fat biopsies blood were obtained from 151 non-selected patients undergoing open surgery. Immunohistochemistry, ELISA, or real-time PCR used for analyzing protein mRNA...
Abstract Background Combined therapy, sodium-glucose cotransporter 2 inhibitors (SGLT2i), and glucagon-like peptide-1 receptor agonists (GLP1ra), regarding monotherapy reduce causes of mortality in patients with diabetes. However, it might differ between women men because their disparate risk burden. Objectives Analyse the differential benefits combined therapy (SGLT2i GLP1ra) vs. or all-cause mortality. Methods We performed a non-concurrent observational prospective study diabetic who were...
Heart failure (HF) is associated with a pro-inflammatory state in epicardial fat, but the involved mechanisms are not entirely clear. The aim of our study was to assess relationship between p53 and adiponectin mRNA adipose tissue (EAT) subcutaneous (SAT) patients heart its sympathetic regulation.Epicardial SAT samples were obtained from 63 undergoing elective cardiac surgery. EAT explants culture seven stimulated isoprenaline 0.1 or 1 uM for 6 h. expression measured frozen biopsies both fat...