A5067729837- Maternal Mental Health During Pregnancy and Postpartum
- Child Abuse and Trauma
- Nicotinic Acetylcholine Receptors Study
- Homicide, Infanticide, and Child Abuse
- Cholinesterase and Neurodegenerative Diseases
- Receptor Mechanisms and Signaling
- Child and Adolescent Psychosocial and Emotional Development
- Suicide and Self-Harm Studies
- Dementia and Cognitive Impairment Research
- Psychiatric care and mental health services
- Schizophrenia research and treatment
- Attachment and Relationship Dynamics
- Child and Adolescent Health
- Memory and Neural Mechanisms
- Music Therapy and Health
- Art Therapy and Mental Health
- Homelessness and Social Issues
- Infant Health and Development
- Participatory Visual Research Methods
- Mental Health Treatment and Access
- Historical Psychiatry and Medical Practices
- Chemical Analysis and Environmental Impact
- Child Nutrition and Feeding Issues
- Primary Care and Health Outcomes
- Grief, Bereavement, and Mental Health
Bionomics (Australia)
2013-2024
Merck & Co., Inc., Rahway, NJ, USA (United States)
2020
VA Portland Health Care System
2018-2019
Somerset Partnership NHS Foundation Trust
2014
Avon and Wiltshire Mental Health Partnership NHS Trust
2008-2013
Portland VA Medical Center
2012
University of Glasgow
2003-2008
University of California, Los Angeles
2001-2005
University of California, Berkeley
2005
NHS Greater Glasgow and Clyde
2004
<h3>Objectives:</h3> Our objective was to compare long-term outcomes of deep brain stimulation (DBS) the globus pallidus interna (GPi) and subthalamic nucleus (STN) for patients with Parkinson disease (PD) in a multicenter randomized controlled trial. <h3>Methods:</h3> Patients randomly assigned GPi (n = 89) or STN DBS 70) were followed 36 months. The primary outcome motor function on stimulation/off medication using Unified Parkinson9s Disease Rating Scale subscale. Secondary included...
<h3>Background</h3> Behavioral abnormalities are common in Alzheimer disease (AD); cholinergic treatment reduces the behavioral disturbances of some patients with AD. Characterizing pretreatment profile who likely to respond therapy will aid efficient use clinical resources. <h3>Objective</h3> To determine baseline for 86 AD treated cholinesterase inhibitor donepezil hydrochloride. <h3>Methods</h3> Open-label retrospective study treatment-related assessments. Based on previous double-blind...
ABSTRACT Dechloromonas strain RCB has been shown to be capable of anaerobic degradation benzene coupled nitrate reduction. As a continuation these studies, the metabolic versatility and hydrocarbon biodegradative capability this organism were investigated. The results revealed that in addition nitrate, could alternatively degrade both aerobically anaerobically with perchlorate or chlorate [(per)chlorate] as suitable electron acceptor. Furthermore, acceptor, also utilize toluene,...
<h3>Abstract</h3> <b>Objectives</b>: To determine whether a serious paracetamol overdose in the medical television drama <i>Casualty</i> altered incidence and nature of general hospital presentations for deliberate self poisoning. <b>Design</b>: Interrupted time series analysis poisoning at accident emergency departments during three week periods before after broadcast. Questionnaire responses collected from patients same periods. <b>Setting</b>: 49 psychiatric services United Kingdom data;...
The purpose of this study was to assess the cross-sectional prevalence and characteristics anxiety among patients with Alzheimer's disease (AD), as compared frontotemporal dementia (FTD), vascular (VaD), normal control subjects. authors used subscale Neuropsychiatric Inventory (NPI), an instrument established reliability validity, compare patients. Patients were identified in a query UCLA Disease Center database included 115 probable AD, 43 VaD, 33 FTD, 40 normal, elderly Descriptive...
A surplus of general pediatricians has been predicted for 1990. This could provide both opportunity and need practitioners to identify areas maternal concern that might guide expansion marketable physician services. For this purpose, concerns were assessed by interviewing 207 mothers seeking care in private pediatric offices. Only 30% most worried about their child's physical health. The remaining 70% concerned problems falling into six categories parenting, behavior, development...
Low-income mother-infant pairs were randomly assigned to rooming-in (N = 143) or routine 158) postpartum contact determine whether affects subsequent adequacy in parenting. At mean age 17 months, two and ten control children had experienced inadequate One eight hospitalized for these problems. five families reported Protective Services mistreatment of the study child; no care adults other than their parents at time data analysis. In this study, correlated with fewer cases parenting inadequacy.
Objectives To explore if short term, high dose vitamin D supplementation is safe and improves balance in persons with Parkinson's disease (PD). Methods A pilot randomized, double-blind intervention trial to measure the effects of 16 weeks (10,000 IU/day) on as well other motor non-motor features PD. We measured balance, gait, strength, falls, cognition, mood, PD severity, quality life before after or placebo. All participants also received 1000 mg calcium once daily. Results Fifty-one...
(1) To investigate the prevalence and characteristics of agitation in patients with Alzheimer's disease (AD) other forms dementia; (2) to explore association between clinical variables, including severity, functional impairment neuropsychiatric symptoms, (3) determine predictors agitation.Data for 427 men women dementia from outpatient clinics University California, Los Angeles Disease Center were analyzed. There 277 AD, 43 vascular dementia, 47 mixed 45 frontotemporal 15 Lewy bodies....
It has been argued that a negative view of the future characterised by impaired positive thinking is associated with increased hopelessness and suicide risk (e.g., MacLeod & Moore, 2000). Hence, central focus two studies reported in this paper was to extend our knowledge investigating its relationship established factors: stress, perfectionism, hopelessness. Study 1 demonstrates, for first time, moderates between stress The findings 2 replicated those found they also supported notion...
<h3>Background</h3> Regional brain correlates of treatment with cholinesterase inhibitors in those Alzheimer disease are unknown. <h3>Objective</h3> To map metabolism associated the response to galantamine fludeoxyglucose F 18 positron emission tomography patients disease. <h3>Design</h3> This is a hypothesis-driven, prospective, open-label study 19 mild moderate examined before and after inhibitor galantamine. Clinical examinations included cognitive portion Disease Assessment Scale,...
<b>Objective</b> To determine the risk of non-fatal self harm in 12 months after discharge from psychiatric inpatient care. <b>Design</b> Cohort study based on national hospital episode statistics. <b>Setting</b> England. <b>Population</b> Patients aged 16-64 years discharged care between 1 April 2004 and 31 March 2005 followed up for one year. <b>Results</b> 75 401 people were over period, 4935 (6.5%) whom admitted at least once following months. Risk was greatest four weeks discharge;...
Abstract Drugs that are clinically effective against anxiety disorders modulate the innate defensive behaviour of rodents, suggesting these illnesses reflect altered functioning in brain systems process threat. This hypothesis is supported humans by discovery intensity threat-avoidance benzodiazepine anxiolytic lorazepam. However, studies used healthy human participants, raising questions as to their validity disorder patients, well generalisability beyond GABAergic drugs. BNC210 a novel...
This work describes the characterization of BNC210 (6-[(2,3-dihydro-1H-inden-2-yl)amino]-1-ethyl-3-(4-morpholinylcarbonyl)-1,8-naphthyridin-4(1H)-one), a selective, small molecule, negative allosteric modulator (NAM) α7 nicotinic acetylcholine receptors (α7 nAChR). With aim to discover non-sedating, anxiolytic compound, was identified during phenotypic screening focused medicinal chemistry library using mouse Light Dark (LD) box evaluate anxiolytic-like activity and Open Field (OF) (dark)...
To examine the relation between rates of psychiatric admissions and both rate unemployment underprivileged area score within small areas.Calculation correlation coefficients explanatory power by using data on from April 1990 to March 1992. Crude age standardised were used based all also number people admitted regardless times each person was admitted.Sectors with an average population 45,000 consisting aggregations neighbouring wards in Bristol District Health Authority electoral 9400 city...
ABSTRACT The dismutation of chlorite into chloride and O 2 represents a central step in the reductive pathway perchlorate that is common to all dissimilatory perchlorate-reducing bacteria mediated by single enzyme, dismutase. dismutase gene cld was isolated sequenced from bacterium Dechloromonas agitata strain CKB. Sequence analysis identified an open reading frame 834 bp would encode mature protein with N-terminal sequence identical previously purified D. enzyme. predicted translation...
The authors retrospectively explored the behavioral and functional imaging profile of Alzheimer's disease (AD) patients who respond to cholinesterase inhibitor therapy by using Neuropsychiatric Inventory (NPI) baseline [99mTc]HMPAO SPECT. Thirty AD were divided into three groups (Responders, Nonresponders, Unchanged) based on their response donepezil. Responders had significantly (P≤0.01) more pretreatment irritability, disinhibition (P≤0.05), euphoria (P=0.05) than Nonresponders lower...