A5004947713- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Animal Behavior and Reproduction
- Pain Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Transcranial Magnetic Stimulation Studies
- Plant and animal studies
- Spinal Cord Injury Research
- Intraoperative Neuromonitoring and Anesthetic Effects
- Neuroscience and Neural Engineering
- Anesthesia and Pain Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Nerve injury and regeneration
- Ion channel regulation and function
- EEG and Brain-Computer Interfaces
- Animal Vocal Communication and Behavior
- Neuroscience and Neuropharmacology Research
- Traumatic Ocular and Foreign Body Injuries
- Avian ecology and behavior
- Trauma Management and Diagnosis
- Pain Management and Treatment
- Nerve Injury and Rehabilitation
- Cerebrospinal fluid and hydrocephalus
- Intracranial Aneurysms: Treatment and Complications
Nature Conservancy of Canada
2023
Arizona State University
2015-2021
University of Windsor
2018-2021
Houston Methodist
2009-2018
Methodist Hospital
2017-2018
Methodist Hospital
2009-2017
Baylor College of Medicine
1997-2015
Trinity University
2014-2015
Richard Wolf (Germany)
2015
Google (United States)
2015
Deep-brain stimulation is the surgical procedure of choice for patients with advanced Parkinson's disease. The globus pallidus interna and subthalamic nucleus are accepted targets this procedure. We compared 24-month outcomes who had undergone bilateral (pallidal stimulation) or (subthalamic stimulation).At seven Veterans Affairs six university hospitals, we randomly assigned 299 idiopathic disease to undergo either pallidal (152 patients) (147 patients). primary outcome was change in motor...
To assess the safety, tolerability, and biological activity of glial cell line-derived neurotrophic factor (GDNF) administered by an implanted intracerebroventricular (ICV) catheter access port in advanced PD.GDNF is a peptide that promotes survival dopamine neurons. It improved 6-OHDA- or MPTP-induced behavioral deficits rodents monkeys.A multicenter, randomized, double-blind, placebo-controlled, sequential cohort study compared effects monthly ICV administration placebo 25, 75, 150, 300,...
<h3>Objectives:</h3> Our objective was to compare long-term outcomes of deep brain stimulation (DBS) the globus pallidus interna (GPi) and subthalamic nucleus (STN) for patients with Parkinson disease (PD) in a multicenter randomized controlled trial. <h3>Methods:</h3> Patients randomly assigned GPi (n = 89) or STN DBS 70) were followed 36 months. The primary outcome motor function on stimulation/off medication using Unified Parkinson9s Disease Rating Scale subscale. Secondary included...
Deep brain stimulation (DBS) surgery is increasingly prominent in the treatment of various disorders refractory to medication. Despite procedure's efficacy, community at large continues be hesitant about presumed associated risks. The main object this study was assess incidence surgical complications occurring both during and after DBS device implantation a population patients with movement an effort better quantify patient risk, define management plans, develop methods for risk avoidance. A...
Object The effects of thalamic deep brain stimulation (DBS) on essential tremor (ET) and Parkinson disease (PD) have been well documented, but there is a paucity long-term data. aim this study was to evaluate the longterm safety efficacy DBS ventralis intermedius nucleus (VIM) thalamus for PD ET. Methods Thirty-eight 45 patients enrolled at five sites completed 5-year follow-up study. There were 26 with ET 19 undergoing 29 unilateral (18 ET/11 PD) 16 bilateral (eight ET/eight procedures....
Objective A 12‐month double‐blind sham‐surgery–controlled trial assessing adeno‐associated virus type 2 (AAV2)‐neurturin injected into the putamen bilaterally failed to meet its primary endpoint, but showed positive results for endpoint in subgroup of subjects followed 18 months and several secondary endpoints. Analysis postmortem tissue suggested impaired axonal transport neurturin from substantia nigra. In present study, we tested safety efficacy AAV2‐neurturin delivered Methods We...
<b>Objective: </b> To determine the efficacy and tolerability of unilateral thalamic deep brain stimulation (DBS) for patients with medically refractory essential tremor (ET) associated Parkinson9s disease (PD). <b>Background: The ET PD may produce functional disability despite optimal medical therapy. Several reports have demonstrated DBS in this scenario. <b>Methods: Preoperative 3-month postoperative ratings were compared 33 (14 19 PD) severe tremor. Evaluations included Unified Disease...
Object The object of this study was to assess the long-term safety deep brain stimulation (DBS) in a large population patients with variety movement disorders. Methods All treated DBS at authors' center between 1995 and 2005 were assessed for intraoperative, perioperative, adverse events (AEs). A total 319 underwent device implantation. Of these 319, 182 suffered from medically refractory Parkinson disease; other had essential tremor (112 patients), dystonia (19 hyperkinetic disorders (six...
Tourette syndrome (TS) is characterized by phonic and motor tics psychiatric comorbidities including attention-deficit (± hyperactivity) disorder (AD/HD), obsessive-compulsive behavior (OCB), anxiety, depression, others.1 The efficacy safety of deep brain stimulation (DBS) in movement disorders are established, their applicability to neuropsychiatric conditions expanding. We describe the results bilateral DBS globus pallidus interna (GPi) a 16-year-old boy with severe, medication-refractory...
Wound complications are uncommon following deep brain stimulation (DBS) surgery. However, certain key technical steps can be performed in each procedure to minimize this still troublesome risk. The authors reviewed the incidence and management of all hardware-related wound dehiscences infections a large patient series.All patients undergoing new DBS hardware implantation surgery between 2002 2010 by single surgeon (R.K.S.) were entered into database after verification cross-referencing...
Background: Unilateral thalamic deep brain stimulation (DBS) is accepted as an effective treatment for essential tremor (ET) and the of Parkinson disease (PD).There are, however, relatively little data concerning bilateral DBS no thorough comparisons between 2 methods.Methods: To assess relative benefit a staged second contralateral placement in patients with PD ET, we compared preoperative baseline assessments those at 3 months after initial implantation, again implantation.The included...
<b><i>Background:</i></b> Deep brain stimulation (DBS) has proven to be an effective treatment for Parkinson’s disease (PD) and other movement disorders, but its usefulness is limited by complications related the hardware. <b><i>Methods:</i></b> We reviewed records of all our patients treated with DBS from January 1996 August 2010 analyzed those hardware reasons surgical revision. <b><i>Results:</i></b> A total 512...
Background and purpose: Subthalamic nucleus deep brain stimulation (STN‐DBS) has been shown to have beneficial effects on the motor features of Parkinson’s disease (PD), but its impact non‐motor symptoms, most notably mood, not fully explored. Methods: In first study independently compare emotional‐cognitive somatic/physiological symptoms depression, we examined mood differences in 17 bilateral STN‐DBS 22 matched non‐surgical PD patients at baseline 6 months. Results: The group reported...
The mechanisms underlying evolutionary changes in sexual dimorphism have long been of interest to biologists. A striking gradient dichromatism exists among songbirds North America, including the wood-warblers (Parulidae): males are generally more colourful than females at northern latitudes, while sexes similarly ornamented lower latitudes. We use phylogenetically controlled comparative analysis test three non-mutually exclusive hypotheses for evolution wood-warblers. first two focus on loss...