A5067762225- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Cerebral Palsy and Movement Disorders
- Mitochondrial Function and Pathology
- Balance, Gait, and Falls Prevention
- Metabolomics and Mass Spectrometry Studies
- Neurobiology of Language and Bilingualism
- Vitamin D Research Studies
- Autism Spectrum Disorder Research
- Diet and metabolism studies
- Health, Environment, Cognitive Aging
- Nuclear Receptors and Signaling
- Tryptophan and brain disorders
- Neuroscience of respiration and sleep
- Ginkgo biloba and Cashew Applications
- Dementia and Cognitive Impairment Research
- Neuroscience and Neural Engineering
- Voice and Speech Disorders
- Treatment of Major Depression
- Restless Legs Syndrome Research
- Congenital Ear and Nasal Anomalies
- Ziziphus Jujuba Studies and Applications
- Natural Compound Pharmacology Studies
- Medical Imaging and Pathology Studies
Oregon Health & Science University
2016-2025
VA Portland Health Care System
2018-2025
Portland VA Medical Center
2016-2023
University of Washington
2023
Veterans Health Administration
2018
Objectives To explore if short term, high dose vitamin D supplementation is safe and improves balance in persons with Parkinson's disease (PD). Methods A pilot randomized, double-blind intervention trial to measure the effects of 16 weeks (10,000 IU/day) on as well other motor non-motor features PD. We measured balance, gait, strength, falls, cognition, mood, PD severity, quality life before after or placebo. All participants also received 1000 mg calcium once daily. Results Fifty-one...
Quantifying the physiology of aging is essential for improving our understanding age-related disease and heterogeneity healthy aging. Recent studies have shown that, in regression models using "-omic" platforms to predict chronological age, residual variation predicted age correlated with health outcomes, suggest that these "omic clocks" provide measures biological age. This paper presents predictive metabolomic profiles cerebrospinal fluid (CSF) from human subjects finds metabolite lipid...
Huntington’s disease (HD) is a devastating neurodegenerative disorder characterized by variety of debilitating symptoms including abnormal motor control, cognitive impairment, and psychiatric disturbances. Despite significant efforts, efficacious treatments to alter the course HD remain elusive, highlighting need explore new therapeutic strategies, lifestyle changes that may delay onset slow progression. Recent research indicates time-restricted eating (TRE), type intermittent fasting where...
Abstract Cognitive impairment in Parkinson’s disease (PD) is pervasive with potentially devastating effects. Identification of those at risk for cognitive decline vital to identify and implement appropriate interventions. Robust multivariate approaches, including fixed-effect, mixed-effect, multitask learning models, were used study associations between biological, clinical, factors predicting status longitudinally a well-characterized prevalent PD cohort ( n = 827). Age, duration, sex, GBA...
Abstract Background As Parkinson's disease progresses, levodopa treatment loses efficacy, partly through the loss of endogenous dopamine‐synthesizing enzyme L‐amino acid decarboxylase (AADC). In phase I PD‐1101 study, putaminal administration VY‐AADC01, an investigational adeno‐associated virus serotype‐2 vector for delivery AADC gene in patients with advanced disease, was well tolerated, improved motor function, and reduced antiparkinsonian medication requirements. Objectives This substudy...
To clarify the specificity of 'hot cross bun' sign (HCBS) for multiple system atrophy (MSA) in adult cerebellar ataxia or parkinsonism.The radiologic information systems at an academic center and affiliated veterans' hospital were queried using keywords bun,' 'pontocerebellar,' 'cruciate,' 'cruciform,' 'MSA,' 'multiple atrophy,' 'multisystem atrophy.' Scans reviewed by a neurologist neuroradiologist to identify HCBS. Subjects with HCBS 2 neurologists most likely etiology patient's neurologic...
Cognitive impairment is a common complication of Parkinson's disease (PD) and identifying risk factors for progression to dementia (PDD) important. However, little research has been done comparing the utility commonly used cognitive screening tests in predicting PD. We retrospectively reviewed data from patients with PD enrolled Pacific Udall Center who had baseline longitudinal neuropsychological global tests. The diagnostic accuracies 3 were compared: Montreal Assessment (MoCA), Mattis...
SRX246 is a vasopressin (AVP) 1a receptor antagonist that crosses the blood-brain barrier. It reduced impulsive aggression, fear, depression and anxiety in animal models, blocked actions of intranasal AVP on aggression/fear circuits an experimental medicine fMRI study demonstrated excellent safety Phase 1 multiple-ascending dose clinical trials. The present was 3-arm, multicenter, randomized, placebo-controlled, double-blind, 12-week, escalation early symptomatic Huntington’s disease (HD)...
DBS in the ventral intermediate nucleus (VIM) of thalamus has been a revolutionary treatment for patients with essential tremor (ET) by reducing tremor. Unfortunately, some develop habituation to and thus experience reduced efficacy loss control. There are no standardized methods addressing DBS. We propose alternating stimulation patterns as way reduce habituation.This was randomized, placebo-controlled trial VIM ET. Patients were randomized either experimental arm on weekly basis or...
In recent years, metabolomics has been used as a powerful tool to better understand the physiology of neurodegenerative diseases and identify potential biomarkers for progression. We targeted untargeted aqueous, lipidomic profiles metabolome from human cerebrospinal fluid build multivariate predictive models distinguishing patients with Alzheimer's disease (AD), Parkinson's (PD), healthy age-matched controls. emphasize several statistical challenges associated metabolomic studies where...
Mucuna pruriens (MP) seeds contain levodopa (up to 2% by weight) and have been used in traditional Indian medicine treat an illness named "Kampavata," now understood be Parkinson's disease (PD). Studies shown MP beneficial, even superior, alone treating PD symptoms. Commercial products containing are readily available from online retail sources patients physicians. Products often extracts of seeds, with significantly higher content than the seeds. However, limited regulatory controls respect...
Introduction: Parkinson's disease (PD) is associated with a range of cognitive deficits. Few studies have carefully examined the subtle impacts PD on cognition among patients who do not meet formal criteria for MCI or dementia. The aim current study was thus to describe impact in those without impairment well-characterized cohort.Methods: Non-cognitively impaired participants (122 PD, 122 age- and sex-matched healthy volunteers) underwent extensive testing. Linear regression analyses...
Cognitive dysfunction is common in Parkinson's disease (PD) and associated with reduced functional abilities increased dependence. To date, however, little known about the relationship between performance of instrumental activities daily living (IADLs) cognitive stages PD, there are conflicting reports as to whether declines specific domains predict IADL impairment.Participants PD were drawn from Pacific Udall Center included study if both participant partner ratings tests completed (n =...
Reduced cortical sensorimotor inhibition is associated with mobility and cognitive impairments in people Parkinson's disease (PD) older adults (OAs). However, there a lack of clarity regarding the relationships among sensorimotor, cognitive, impairments. The purpose this study was to determine how relates cognition PD OAs. Cortical characterized short-latency afferent (SAI) 81 69 Six inertial sensors recorded single- dual-task gait postural sway characteristics during 2-minute walk 1-minute...
Abstract The extent to which the heterogeneity of gait and balance problems in PD may be explained by genetic variation is unknown. Variants glucocerebrosidase ( GBA ) gene are strongest known risk factor for associated with greater motor cognitive severity. However, impact variants on comprehensive measures their relationship cognition remains We aimed determine differences impairments those without (mutation carriers E326K polymorphism) explore direct indirect effects status gait, balance,...
Introduction: Amantadine anecdotally improves gait in progressive supranuclear palsy (PSP) but definitive data is lacking. We investigated associations between amantadine usage, gait, cognition, and activities of daily living 310 subjects with PSP using from the davunetide trial. Method: compared baseline demographics, Rating Scale (PSPRS), Repeat Battery for Assessment Neuropsychological Status (RBANS), Schwab England Activities Daily Living (SEADL) scores taking vs. not chi-square tests...
Traditionally, the standard of care for medication refractory essential tremor has been to utilize omnidirectional deep brain stimulation ventral intermediate nucleus. The advent directional allows spatial restriction on selected targets without involving neighboring structures, thereby limiting off-target side effects and improving clinical utility.We performed a retrospective review patients between February 2017 September 2019 who had received nucleus that allowed programming...
Objective: To examine the relationship between psychological stress and Parkinson’s disease progression. Background: Animal studies suggest that (PD) pathology is negatively affected by stress. More stressful life events may increase risk of PD. Stress increases damage to dopamine cells results in more severe parkinsonian symptoms animal studies. In humans, acute can worsen bradykinesia, motor blocking (freezing), tremor it hypothesized affect synthesis release. Design/Methods: Data from...