Eating at a time when the internal circadian clock promotes sleep is novel risk factor for weight gain and obesity, yet little known about mechanisms by which misalignment leads to metabolic dysregulation in humans. We studied 14 adults 6-d inpatient simulated shiftwork protocol quantified changes energy expenditure, macronutrient utilization, appetitive hormones, sleep, phase during day versus nightshift work. found that total daily expenditure increased ∼4% on transition first nightshift,...

Wearable and mobile devices that capture multimodal data have the potential to identify risk factors for high stress poor mental health provide information improve well-being.

Caffeine delays the human circadian clock and affects cellular timekeeping through an adenosine receptor–dependent mechanism.

What can wearable sensors and usage of smart phones tell us about academic performance, self-reported sleep quality, stress mental health condition? To answer this question, we collected extensive subjective objective data using mobile phones, surveys, worn day night from 66 participants, for 30 days each, totaling 1,980 data. We analyzed daily monthly behavioral physiological patterns identified factors that affect performance (GPA), Pittsburg Sleep Quality Index (PSQI) score, perceived...

Short sleep duration and circadian misalignment are hypothesized to causally contribute health problems including obesity, diabetes, metabolic syndrome, heart disease, mood disorders, cognitive impairment, accidents [1Depner C.M. Stothard E.R. Wright Jr., K.P. Metabolic consequences of disorders.Curr. Diab. Rep. 2014; 14: 507Crossref PubMed Scopus (253) Google Scholar, 2Newman A.B. Enright P.L. Manolio T.A. Haponik E.F. Wahl P.W. Sleep disturbance, psychosocial correlates, cardiovascular...

Abstract: Sleep inertia, or the grogginess felt upon awakening, is associated with significant cognitive performance decrements that dissipate as time awake increases. This impairment in has been observed both tightly controlled in-laboratory studies and real-world scenarios. Further, these are exaggerated by prior sleep loss of day which a person awakens. review will examine current insights into causes factors may positively negatively influence degree consequences inertia laboratory...

Significance Circadian misalignment (i.e., behavioral processes such as food intake or sleep occurring at inappropriate endogenous circadian times) commonly occurs during shift work and is associated with health problems. Identifying mechanisms underlying problems will help develop precision medicine countermeasures. Thus, we investigated the impact of on human plasma proteome using a simulated nightshift protocol in healthy volunteers. We demonstrate that and/or wake–sleep/food...

Abstract Study Objectives Sleep regularity, in addition to duration and timing, is predictive of daily variations well-being. One possible contributor changes these sleep dimensions are early morning scheduled events. We applied a composite metric—the Composite Phase Deviation (CPD)—to assess mistiming irregularity both event schedules examine their relationship with self-reported well-being US college students. Methods Daily well-being, actigraphy, timing first events...

Significance Millions of individuals obtain insufficient sleep on a daily basis, which leads to impaired performance. Whether these decrements are caused by short duration or extended wakefulness is unknown. In this study, healthy volunteers were randomized into either chronically sleep-restricted control protocol while living 20-h “day,” thus enabling without wakefulness. We demonstrate that chronic sleep, even wakefulness, neurobehavioral performance at all times the day, when circadian...

On March 11th, 2020, the National Basketball Association (NBA) paused its season after ~ 64 games due to Coronavirus 2019 (COVID-19) outbreak, only resume 5 months later with top 22 teams isolated together (known as "bubble") in Orlando, Florida play eight each an end regular season. This restart, no new travel by teams, provided a natural experiment whereby impact of and home-court advantage could be systematically examined. We show here that pre-COVID-19 season, traveling across time zones...

We collected and analyzed subjective objective data using surveys wearable sensors worn day night from 68 participants for ~30 days each, to address questions related the relationships among sleep duration, irregularity, self-reported Happy-Sad mood other daily behavioral factors in college students. this physiological (i) identify that classified into support vector machines (SVMs); (ii) analyze how accurately duration regularity past 1-5 morning mood. found statistically significant...

Objective- Adverse cardiovascular events occur more frequently in the morning than at other times of day. Vascular endothelial function (VEF)-a robust risk marker-is impaired during this period. We recently discovered that impairment VEF is not caused by either overnight sleep or inactivity accompanies sleep. determined whether endogenous circadian system responsible for VEF. also assessed affects mechanistic biomarkers, is, oxidative stress (malondialdehyde adducts), endothelin-1, blood...

The timing of caloric intake is a risk factor for excess weight and disease. Growing evidence suggests, however, that the impact consumption on metabolic health depends its circadian phase, not clock hour. objective current study was to identify how individuals consume calories macronutrients relative phase in real-world settings. Young adults (n = 106; aged 19 ± 1 years; 45 females) photographically recorded content all seven consecutive days using smartphone application during 30-day...

Caffeine promotes wakefulness during night shift work, although it also disturbs subsequent daytime sleep. Increased alertness by caffeine is associated with a higher core body temperature (CBT). A lower CBT and narrow distal-to-proximal skin gradient (DPG) have been reported to be improved sleep, yet whether influences the DPG unknown. We tested hypothesis that use nighttime total sleep deprivation would reduce DPG, increase alertness, disturb recovery expected greater widening of prior...

Demands of modern society force many work operations into the night when internal circadian timekeeping system is promoting sleep. The combination disturbed daytime sleep and misalignment, which common in overnight shift work, decreases cognitive performance, yet how performance may differ across multiple consecutive nights not fully understood. Therefore, primary aim this study was to use a simulated night-shift protocol examine ratings sleepiness clear-headedness hours typical shift, first...

Sleep inertia, subjectively experienced as grogginess felt upon awakening, causes cognitive performance impairments that can require up to 1.5 hr dissipate. It is unknown, however, how chronic sleep restriction (CSR) influences the magnitude and duration of inertia–related deficits. Twenty-six healthy participants were enrolled in one two in-laboratory protocols (one 32 day randomized control 38 protocol) separated influence circadian effects on using different "day"-lengths (20 42.85...

Chronic circadian disruption (CCD), such as occurs during rotating shiftwork, and insufficient sleep are each independently associated with poor health outcomes, including obesity glucose intolerance. A potential mechanism for is increased energy intake (i.e., eating), particularly the night, when physiological response to altered. However, contributions of CCD subjective hunger, appetite, food preference, appetitive hormones not clear. To disentangle influences these factors, we studied...