A5061035625- Circadian rhythm and melatonin
- Sleep and related disorders
- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- Sleep and Wakefulness Research
- Sleep and Work-Related Fatigue
- Respiratory Support and Mechanisms
- Telemedicine and Telehealth Implementation
- Obesity, Physical Activity, Diet
- Blood Pressure and Hypertension Studies
- Dietary Effects on Health
- Mobile Health and mHealth Applications
- Nutritional Studies and Diet
- Electronic Health Records Systems
- Diet and metabolism studies
- Diabetes Management and Education
- Tracheal and airway disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Complex Systems and Time Series Analysis
- Cardiovascular Health and Disease Prevention
- Lipoproteins and Cardiovascular Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Birth, Development, and Health
Oregon Health & Science University
2016-2025
Columbia University
2012-2025
University of Minnesota
2023
Johns Hopkins University
2014-2023
National Institute for Occupational Safety and Health
2023
Centers for Disease Control and Prevention
2023
United States Nuclear Regulatory Commission
2023
Henan Province Quality and Technical Supervision Bureau
2023
University of Washington
2014-2023
Portland State University
2017-2023
There is considerable epidemiological evidence that shift work associated with increased risk for obesity, diabetes, and cardiovascular disease, perhaps the result of physiologic maladaptation to chronically sleeping eating at abnormal circadian times. To begin understand underlying mechanisms, we determined effects such misalignment between behavioral cycles (fasting/feeding sleep/wake cycles) endogenous on metabolic, autonomic, endocrine predictors risk. Ten adults (5 female) underwent a...
Epidemiological studies link short sleep duration and circadian disruption with higher risk of metabolic syndrome diabetes. We tested the hypotheses that prolonged restriction concurrent disruption, as can occur in people performing shift work, impairs glucose regulation metabolism. Healthy adults spent >5 weeks under controlled laboratory conditions which they experienced an initial baseline segment optimal sleep, 3 (5.6 hours per 24 hours) combined (recurring 28-hour "days"), followed by 9...
The prevalence of Alzheimer disease (AD) is increasing in the elderly, and vascular risk factors may increase its risk.To explore association aggregation with AD.The authors followed 1,138 individuals without dementia at baseline (mean age 76.2) for a mean 5.5 years. presence was related to incident possible probable AD.Four (diabetes, hypertension, heart disease, current smoking) were associated higher AD (p < 0.10) when analyzed individually. increased number (diabetes + hypertension...
<b><i>Objective:</i></b> To explore the association between fasting insulin levels and dementia. <b><i>Methods:</i></b> Fasting were measured from frozen sera using solid-phase chemiluminescent enzyme immunoassay in a sample of elderly subjects chosen at random cohort persons aged 65 years older northern Manhattan. Dementia was diagnosed standard methods. Neuropsychiatric testing available on all each follow-up interval. <b><i>Results:</i></b> A total 683 without prevalent dementia followed...
It has been suggested that deposition of fat in the soft tissues surrounding upper airway may be an important factor pathogenesis obstructive sleep apnoea (OSA) obese subjects. We have used magnetic resonance imaging to determine site(s) and size(s) deposits around six patients with OSA (116-153% ideal body weight) five weight-matched controls without (107-152% weight). In all subjects, large were present postero-lateral oropharyngeal airspace at level palate. Significantly more was these...
Background: Diet may play a role in Alzheimer disease (AD).Objective: To examine the association between caloric intake and AD.Methods: Elderly individuals free of dementia at baseline (N=980) were followed for mean 4 years.Daily calories, carbohydrates, fats, protein recalled using semiquantitative food frequency questionnaire administered first follow-up visits.Proportional hazards models used to associations quartiles incident AD, adjusting confounders.Results: There 242 cases AD during...
Background:The generation of oxygen free radicals is involved in the pathogenesis Alzheimer disease (AD).Objective: To determine whether intake antioxidant vitamins decreases risk AD. Methods:We investigated relationship between AD and carotenes, vitamin C, E 980 elderly subjects Washington Heights-Inwood Columbia Aging Project who were dementia at baseline followed for a mean time 4 years.Semiquantitative food frequency questionnaires administered first follow-up visit.Cox proportional...
Glucose tolerance is lower in the evening and at night than morning. However, relative contribution of circadian system vs. behavioral cycle (including sleep/wake fasting/feeding cycles) unclear. Furthermore, although shift work a diabetes risk factor, separate impact on glucose cycle, phase, disruption (i.e., misalignment between central pacemaker cycle) has not been systematically studied. Here we show--by using two 8-d laboratory protocols--in healthy adults that have distinct influences...
<h3>Context</h3>Sleep disorders often remain undiagnosed. Untreated sleep among police officers may adversely affect their health and safety pose a risk to the public.<h3>Objective</h3>To quantify associations between disorder self-reported health, safety, performance outcomes in officers.<h3>Design, Setting, Participants</h3>Cross-sectional prospective cohort study of North American participating either an online or on-site screening (n=4957) monthly follow-up surveys (n=3545 representing...
The risk of adverse cardiovascular events peaks in the morning (≈9:00 AM) with a secondary peak evening (≈8:00 PM) and trough at night. This pattern is generally believed to be caused by day/night distribution behavioral triggers, but it unknown whether endogenous circadian system contributes these daily fluctuations. Thus, we tested hypotheses that modulates autonomic, hemodynamic, hemostatic markers rest, stressors have different effects when they occur internal phases. Twelve healthy...
Abstract Objective: Despite the extended overnight fast, paradoxically, people are typically not ravenous in morning and breakfast is smallest meal of day. We assessed whether this paradox could be explained by an endogenous circadian influence on appetite with a trough, while controlling for sleep/wake fasting/feeding effects. Design Methods: Twelve healthy non‐obese adults (six males; age, 20‐42 years) were studied throughout 13‐day laboratory protocol that balanced all behaviors,...
Telemedicine is a promising but largely unproven technology for providing case management services to patients with chronic conditions who experience barriers access care or high burden of illness.The authors conducted randomized, controlled trial comparing telemedicine usual care, blinding those obtaining outcome data, in 1,665 Medicare recipients diabetes, aged 55 years greater, and living federally designated medically underserved areas New York State. The primary endpoints were HgbA1c,...
To establish the evidence base for diagnosis of sleep apnea (SA) in adult patients, a systematic review literature from 1980 through November 1, 1997 was performed. Diagnostic studies were included if they reported results any test to or support SA, comparison full polysomnogram (PSG). Test meta-analyzed using fixed effects models and summary receiver operating characteristic curves (ROCs) examine consistency tests within between diagnostics vs. "gold standard" PSG. From total 937 studies,...
Leptin and adiponectin play important physiological roles in regulating appetite, food intake, energy balance have pathophysiological obesity anorexia nervosa. To assess the relative contributions of day/night patterns behaviors (sleep/wake cycle intake) endogenous circadian pacemaker on observed adipokines, six healthy subjects we measured circulating leptin, soluble leptin receptor, adiponectin, glucose, insulin levels throughout a constant routine protocol (38 h wakefulness with posture,...
To describe the development and validation of low literacy English Spanish versions 26-item Telemedicine Satisfaction Usefulness Questionnaire (TSUQ), report telemedicine satisfaction usefulness ratings urban rural participants in Informatics for Diabetes Education (IDEATel) project, explore relationships between utilization perceptions usefulness.Data sources included TSUQ, data from IDEATel log files, sociodemographic annual interview. Psychometric analyses were conducted to examine...
The reliability of the Behavioral Risk Factor Surveillance System questionnaire was assessed in a random sample adults (n = 122) and separate Black Hispanic 200) Massachusetts. administered twice, 21 to 44 days apart, by telephone (210 completed reinterviews, 65% response rate for second administration). There were no statistically significant differences distribution demographic or risk factor variables across administrations. Individual-level (kappa categorical variables, correlation...
Pharyngeal dilator muscle activation (GGEMG) during wakefulness is greater in patients with obstructive sleep apnea (OSA) than healthy control subjects, representing a neuromuscular compensatory mechanism for more collapsible airway. As previous work from our laboratory has demonstrated close relationship between GGEMG and epiglottic pressure, we examined the genioglossal activity pressure subjects across wide range of pressures basal breathing, negative-pressure (iron-lung) ventilation,...
<h3>Background</h3> Borderline personality disorder (BPD) is a severe and chronic psychiatric characterized by marked impulsivity, instability of affect interpersonal relationships, suicidal behavior that can complicate medical care. Few data are available on its prevalence or clinical presentation outside specialty mental health care settings. <h3>Methods</h3> We examined from survey conducted systematic sample (N = 218) an urban primary practice to study the prevalence, features,...
Platelets are involved in the thromboses that central to myocardial infarctions and ischemic strokes. Such adverse cardiovascular events have day/night patterns with peaks morning (~9 AM), potentially related endogenous circadian clock control of platelet activation. The objective was test if human system influences (1) function (2) response standardized behavioral stressors. We also aimed compare magnitude any effects on caused by varied stressors, including mental arithmetic, passive...
The present study was designed to determine the effect of sleep on reflex pharyngeal dilator muscle activation by stimuli negative airway pressure in human subjects. Intra-oral bipolar surface electrodes were used record genioglossus electromyogram (EMG) responses 500 ms duration 0 and -25 cmH2O applied, via a face-mask, four normal Stimuli applied during early inspiration wakefulness periods non-rapid-eye-movement (non-REM) sleep, defined electroencephalographic (EEG) criteria. rectified...
Computed tomography has been used to study the pharyngeal airway during tidal breathing in wakefulness and obstructive apnoeas Non-REM sleep patients with apnoea. In supine subjects, contiguous transverse 10 mm sections were taken perpendicular posterior wall a 2.1 s scan time. Studies showed that narrowest section of airspace was region soft palate minimal cross-sectional areas significantly reduced group apnoea compared control subjects without The studies all patients, site apnoeas....