A5083734871- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Restless Legs Syndrome Research
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Neuroscience and Neural Engineering
- Functional Brain Connectivity Studies
- Nuclear Receptors and Signaling
University of Nebraska Medical Center
2018-2024
Oregon Health & Science University
2017
Portland VA Medical Center
2017
Oregon Medical Research Center
2016
To compare motor and nonmotor outcomes at 6 months of asleep deep brain stimulation (DBS) for Parkinson disease (PD) using intraoperative imaging guidance to confirm electrode placement vs awake DBS microelectrode recording placement.DBS candidates with PD referred Oregon Health & Science University underwent guidance. Six-month were compared those patients who previously by the same surgeon center. Assessments included an "off"-levodopa Unified Parkinson's Disease Rating Scale (UPDRS) II...
DBS in the ventral intermediate nucleus (VIM) of thalamus has been a revolutionary treatment for patients with essential tremor (ET) by reducing tremor. Unfortunately, some develop habituation to and thus experience reduced efficacy loss control. There are no standardized methods addressing DBS. We propose alternating stimulation patterns as way reduce habituation.This was randomized, placebo-controlled trial VIM ET. Patients were randomized either experimental arm on weekly basis or...
Objective: To compare the difference in deep brain stimulation (DBS) surgery outcomes for Parkinson's disease (PD) comparing targeting via intraoperative computed tomography imaging (ICT) to microelectrode recording (MER). Background: MER has been gold standard DBS targeting, however it requires more penetrations, patients are awake, and operative time is longer. ICT allows equal accuracy of placement, appealing since performed under anesthesia, may result lower morbidity. Methods: PD...