A5003103747- Amyotrophic Lateral Sclerosis Research
- Epigenetics and DNA Methylation
- Neurogenetic and Muscular Disorders Research
- COVID-19 and Mental Health
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Migration, Health and Trauma
- Dementia and Cognitive Impairment Research
- Posttraumatic Stress Disorder Research
- Neurological Disorders and Treatments
- Williams Syndrome Research
- Birth, Development, and Health
- Neurological Disease Mechanisms and Treatments
- Terrorism, Counterterrorism, and Political Violence
- Traumatic Brain Injury Research
- Neuroscience of respiration and sleep
- Resilience and Mental Health
- Diet and metabolism studies
- Pharmaceutical Practices and Patient Outcomes
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Transplantation: Methods and Outcomes
- MicroRNA in disease regulation
- Autism Spectrum Disorder Research
- Health and Conflict Studies
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
2020-2024
The University of Texas Health Science Center at Houston
2010-2024
The University of Texas Southwestern Medical Center
2024
Southwestern Medical Center
2024
University of Zurich
2013-2022
ETH Zurich
2014-2022
ORCID
2022
Wright-Patterson Air Force Base
2022
UES (United States)
2022
Lahore Garrison University
2021
Accumulation of the DNA/RNA binding protein fused in sarcoma as cytoplasmic inclusions neurons and glial cells is pathological hallmark all patients with amyotrophic lateral sclerosis mutations FUS well several subtypes frontotemporal lobar degeneration, which are not associated mutations. The mechanisms leading to inclusion formation sarcoma-associated neurodegeneration only poorly understood. Because belongs a family proteins known FET, also includes Ewing's TATA-binding protein-associated...
Microglia coordinate various functions in the central nervous system ranging from removing synaptic connections, to maintaining brain homeostasis by monitoring neuronal function, and clearing protein aggregates across lifespan. Here we investigated whether increased microglial phagocytic activity that clears amyloid can also cause pathological synapse loss. We identified TDP-43, a DNA-RNA binding encoded Tardbp gene, as strong regulator of phagocytosis. Mice lacking TDP-43 microglia exhibit...
This systematic review analyzed data from studies examining memory and cognitive function in subjects with posttraumatic stress disorder (PTSD), compared exposed to trauma (but without PTSD). Based on analysis of 21 articles published English 1968 2009, the conclusion is that individuals PTSD, particularly veterans, show signs impairment when tested neuropsychological instruments, more so than who do not have PTSD.
Our objective was to test the hypothesis that changes in body mass index (BMI) are associated with clinical course of ALS. We examined relationships between BMI at first visit and up a two-year follow-up, multiple variables related ALS: age onset, rate progression motor symptoms, survival. Baseline classified according World Health Organization (WHO) criteria. Changes were as loss >1 unit, no change, or gain unit. results showed baseline not In contrast, over two years significantly shorter...
Objectives: To ascertain factors associated with worsening of psychiatric conditions during the coronavirus disease 2019 (COVID-19) pandemic. Methods: This study anonymously examined 2,734 patients worldwide for their preexisting COVID-19 An independent clinical investigation 318 from United States was used verification. Results: Valid responses mainly 12 featured countries indicated self-reported in two-thirds assessed that through significantly higher scores on scales general psychological...
Cognitive impairment secondary to frontal lobe atrophy exists in 40-60% of Amyotrophic Lateral Sclerosis (ALS) cases. We aimed determine the prevalence frontal-lobe mediated behavioral and ascertain its relationship cognitive impairment.Two-hundred twenty five patients diagnosed with sporadic ALS were evaluated for dysfunction using Frontal Systems Behavior Scale (FrSBe), a validated measure used examine behaviors, specifically apathy, executive disinhibition; total behavior score is also...
Abstract Background Compared with other major dementias, very little is known about the medical and environmental risk factors associated frontotemporal dementia (FTD). In this study, we evaluated disorders FTD in a veteran population. Methods The records of 845 consecutive veterans who were for cognitive and/or behavioral complaints at clinic an academic center between March 1, 2003, June 30, 2008, reviewed 554 patients received diagnosis dementia. Medical 63 variant compared 491 non‐FTD...
Several metabolic derangements associated with diabetes mellitus type 2 (DM) have been a better outcome in amyotrophic lateral sclerosis (ALS), including hyperlipidemia and obesity. Here, we tested the hypothesis that DM would positive effect on motor cognitive findings of ALS.We compared data from ALS patients pre-morbid (ALS-DM; n = 175) versus without (ALS; 2196) regard to age onset, rate progression, survival, neuropsychological test performance.The onset was later for women, Caucasians...
This study anonymously screened 13,332 individuals worldwide for psychological symptoms related to Corona virus disease 2019 (COVID-19) pandemic from March 29th April 14th, 2020. A total of n=12,817 responses were considered valid with 12 featured countries and five WHO regions. Female gender, pre-existing psychiatric condition, prior exposure trauma identified as notable risk factors, whereas optimism, ability share concerns family friends like usual, positive prediction about COVID-19,...
Background: Despite an alarming rise in the global prevalence of dementia, available modalities for improving cognition and mental wellbeing dementia patients remain limited. Environmental enrichment is experimental paradigm that has shown promising anti-depressive memory-enhancing effects pre-clinical studies. However, its clinical utility remained limited due to lack effective implementation strategies. Objective: The primary objective this study was evaluate usability (tolerability...
Abstract Memory formation is a complex cognitive function regulated by coordinated synaptic and nuclear processes in neurons. In mammals, it controlled multiple molecular activators suppressors, including the key signalling regulator, protein phosphatase 1 (PP1). Here, we show that memory control PP1 involves miR-183/96/182 cluster its selective regulation during formation. Inhibiting mouse brain, or training on an object recognition task similarly increases expression hippocampus. Mimicking...
Article9 October 2020Open Access Transparent process Involvement of circulating factors in the transmission paternal experiences through germline Gretchen van Steenwyk orcid.org/0000-0001-8225-3818 Laboratory Neuroepigenetics, Brain Research Institute, Medical Faculty University Zurich, Switzerland Institute for Neuroscience, Department Health Sciences and Technology, ETH Zurich Neuroscience Center, Search more papers by this author Katharina Gapp Molecular Behavioral Gurdon Cambridge, UK...
Abstract This study anonymously screened 13,332 individuals worldwide for psychological symptoms related to Corona virus disease 2019 (COVID-19) pandemic from March 29 th April 14 , 2020. A total of n=12,817 responses were considered valid with 12 featured countries and five WHO regions. Female gender, pre-existing psychiatric condition, prior exposure trauma identified as notable risk factors, whereas optimism, ability share concerns family friends like usual, positive prediction about...
OBJECTIVES This study aims to determine the diagnostic accuracy of twinkling artifact Doppler ultrasound in predicting urinary tract calculi by taking a CT scan as gold standard patients presenting radiology department at Hayatabad Medical Complex Peshawar. METHODOLOGY A cross-sectional was conducted Radiology Department Peshawar duration 22nd April 2021 October 2021A total 206 suspected having were included consecutively and subjected followed KUB. RESULTSThe mean age sample 42.3 + 9.1...