A5017326949- Voice and Speech Disorders
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Dysphagia Assessment and Management
- Phonetics and Phonology Research
- Botulinum Toxin and Related Neurological Disorders
- Stuttering Research and Treatment
- Neuroscience and Music Perception
- Transcranial Magnetic Stimulation Studies
- Tactile and Sensory Interactions
- Spondyloarthritis Studies and Treatments
- Genetic Neurodegenerative Diseases
- Functional Brain Connectivity Studies
- French Language Learning Methods
- Psoriasis: Treatment and Pathogenesis
- Pregnancy and Medication Impact
- EEG and Brain-Computer Interfaces
- Multisensory perception and integration
- Natural Language Processing Techniques
- Cerebral Palsy and Movement Disorders
- Autism Spectrum Disorder Research
- Language Development and Disorders
- Rheumatoid Arthritis Research and Therapies
- Gestational Diabetes Research and Management
- Linguistics and Discourse Analysis
Universidade Estadual de Santa Cruz
2025
Centre National de la Recherche Scientifique
2015-2024
Aix-Marseille Université
2015-2024
Inserm
2001-2024
Sorbonne Université
2023-2024
Assistance Publique – Hôpitaux de Paris
2020-2024
Institut Pierre Louis d‘Épidémiologie et de Santé Publique
2023-2024
Google (United States)
2024
Laboratoire Parole et Langage
2013-2023
Pitié-Salpêtrière Hospital
2023
Background: Parkinson’s disease (PD) is a complex neurodegenerative disorder impacting everyday function and quality of life. Rehabilitation plays crucial role in improving symptoms, function, life reducing disability, particularly given the lack disease-modifying agents limitations medications surgical therapies. However, rehabilitative care under-recognized under-utilized PD often only utilized later stages, despite research guidelines demonstrating its positive effects. Currently, there...
<h3>Objective:</h3> Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment for advanced Parkinson disease (PD). Following STN-DBS, speech intelligibility can deteriorate, limiting its beneficial effect. Here we prospectively examined the short- and long-term response to STN-DBS in a consecutive series of patients identify clinical surgical factors associated with change. <h3>Methods:</h3> Thirty-two were assessed before surgery, then 1 month, 6 months, year after 4...
<h3>Objective</h3> To investigate predictors for improvement of disease-specific quality life (QOL) after deep brain stimulation (DBS) the subthalamic nucleus (STN) Parkinson disease (PD) with early motor complications. <h3>Methods</h3> We performed a secondary analysis data from previously published EARLYSTIM study, prospective randomized trial comparing STN-DBS (n = 124) to best medical treatment 127) 2 years follow-up QOL (39-item Parkinson9s Disease Questionnaire summary index...
Abstract Background: Parkinsonian dysarthria (as typically characterized by hypophonia, monotony of pitch, and rhythm abnormalities) is often accompanied gait disturbances. The long‐term effect subthalamic nucleus deep brain stimulation (STN DBS) on remains unclear. Methods: Given STN DBS's known improvement disorders, we analyzed speech intelligibility aerodynamic acoustic parameters in 11 advanced PD patients three double‐blind, randomized conditions: “defined Off,” 60 Hz DBS 130 DBS....
In Parkinson's disease, functional imaging studies during limb motor tasks reveal cerebral activation abnormalities that can be reversed by subthalamic nucleus (STN) stimulation. The effect of STN stimulation on parkinsonian dysarthria has not, however, been investigated using PET. aim the present study was to evaluate regional blood flow (rCBF) speech production and silent articulation in patients with disease. Ten disease surgically implanted bilaterally significant improvement their...
Abstract Levodopa ( L ‐dopa) and subthalamic nucleus (STN) stimulation treatments have been associated with both improvement exacerbation of dysarthria in Parkinson's disease (PD). We report four cases illustrating variant responses to dopaminergic STN therapies. Patients' motor disability were perceptually rated by the Unified Disease Rating Scale (UPDRS) conditions according medication stimulation. Dedicated software packages allowed acquisition analysis acoustic recordings. Case 1, who...
Cross-linguistic studies aim at determining the similarities and differences in speech production by uncovering linguistic adaptations to specific constraints environments. In field of motor disorders, such a cross-language approach could be great interest understand not only deficits that are induced pathology, but also difficulties patients' language. From more clinical point view, cross-linguistic should specifically focus on relationship between disorders intelligibility. The this...
To investigate the effects of bilateral subthalamic nucleus (STN) stimulation on patterns brain activation during random number generation (RNG), a task that requires suppression habitual counting and response selection under competition. We used [Formula: see text] positron emission tomography to changes regional cerebral blood flow (rCBF) induced by STN RNG task, in six patients with Parkinson's disease. Paced at 1 Hz was compared control task. Both tasks were performed off medication deep...
Levodopa (L-dopa) effects on the cardinal and axial symptoms of Parkinson's disease (PD) differ greatly, leading to therapeutic challenges for managing disabilities in this patient's population. In context, we studied cerebral networks associated with production a unilateral hand movement, speech production, task combining both tasks 12 individuals PD, off levodopa (L-dopa). Unilateral movements medication state elicited brain activations motor regions (primary cortex, supplementary area,...
Improvement of gait disorders following pedunculopontine nucleus area stimulation in patients with Parkinson's disease has previously been reported and led us to propose this surgical treatment who progressively developed severe freezing despite optimal dopaminergic drug subthalamic stimulation. The outcome our prospective study on the first six was somewhat mitigated, as falls related were improved by low frequency electrical some, but not all, patients. Here, we report speech data...
Individuals with Parkinson's disease (PD) have to deal several aspects of voice and speech decline thus alteration communication ability during the course disease. Among these impairments, 3 major challenges include: (1) dysarthria, consisting orofacial motor dysfunction dysprosody, which is linked neurodegenerative processes; (2) effects pharmacological treatment, vary according stage; (3) particular modifications that may be language-specific, is, dependent on language spoken by patients....