A5091322783- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Transcranial Magnetic Stimulation Studies
- Pain Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Health, Medicine and Society
- Neurological diseases and metabolism
- Neurological and metabolic disorders
- Autism Spectrum Disorder Research
- Obsessive-Compulsive Spectrum Disorders
- Heart Rate Variability and Autonomic Control
- Epilepsy research and treatment
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Syncope and Autonomic Disorders
- Healthcare Systems and Practices
- Neuroscience and Neuropharmacology Research
- Schizophrenia research and treatment
- Neuroendocrine regulation and behavior
- Pharmacological Effects and Toxicity Studies
- Pain Management and Placebo Effect
- Electroconvulsive Therapy Studies
- Treatment of Major Depression
- Restless Legs Syndrome Research
- Opioid Use Disorder Treatment
Inserm
2015-2025
Centre Hospitalier Universitaire de Toulouse
2010-2025
Université de Toulouse
2015-2025
French Clinical Research Infrastructure Network
2020-2025
Université Toulouse III - Paul Sabatier
2012-2024
Centre National de la Recherche Scientifique
2013-2024
Université de Strasbourg
2024
Institut de génétique et de biologie moléculaire et cellulaire
2024
Hôpital Purpan
2005-2023
Hôpital Paule de Viguier
2017-2022
Abstract Patients suffering from Parkinson's disease (PD) frequently experienced painful sensations that could be in part due to central modification of nociception. We compared pain threshold before and after administration levodopa PD patients controls, investigated cerebral activity with positron emission tomography (PET) during experimental nociceptive stimulation. Pain was determined using thermal stimulation two randomized conditions: off on . performed H 2 15 O PET analysis regional...
Patients suffering from Parkinson's disease (PD) describe painful sensations that could be related to neuropathic pain. Experimental data have indicated the involvement of basal ganglia and dopaminergic pathways in central nociceptive processing.The objective this study was assess compare effect levodopa on pain threshold patients with PD healthy subjects.The assessed by flexion reflex (RIII) 13 10 subjects. subjects were evaluated under two randomised conditions: (ON) without (OFF).Levodopa...
The AMANDYSK trial was designed to assess long-term efficacy of chronic treatment with amantadine in patients Parkinson disease (PD) and levodopa-induced dyskinesia (LID).This a 3-month, multicenter, randomized, double-blind, placebo-controlled, parallel-group, wash-out study conducted 57 amantadine-treated (≥200 mg/d for ≥6 months) dyskinetic PD. primary outcome measure the change from baseline Unified Parkinson's Disease Rating Scale (UPDRS) subscore (items 32 [duration] + 33 [severity])....
Abstract The “Ardouin Scale of Behavior in Parkinson's Disease” is a new instrument specifically designed for assessing mood and behavior with view to quantifying changes related disease, dopaminergic medication, non‐motor fluctuations. This study was aimed at analyzing the psychometric attributes this scale patients disease without dementia. In addition scale, following measures were applied: Unified Disease Rating Scale, Montgomery Asberg Depression Lille Apathy Bech Rafaelsen Mania...
<h3>Objective</h3> To investigate predictors for improvement of disease-specific quality life (QOL) after deep brain stimulation (DBS) the subthalamic nucleus (STN) Parkinson disease (PD) with early motor complications. <h3>Methods</h3> We performed a secondary analysis data from previously published EARLYSTIM study, prospective randomized trial comparing STN-DBS (n = 124) to best medical treatment 127) 2 years follow-up QOL (39-item Parkinson9s Disease Questionnaire summary index...
Abnormal accumulation of ferritin was found to be associated with an autosomal dominant slowly progressing neurodegenerative disease clinically characterized by tremor, cerebellar ataxia, parkinsonism and pyramidal signs, behavioral disturbances, cognitive decline. These symptoms may appear sequentially over a period 4 decades. Pathologically, intranuclear intracytoplasmic bodies were in glia subsets neurons the central nervous system as well extraneural tissue. Biochemical analyses these...
Abstract We conducted a randomized, double‐blind, placebo‐controlled, single‐patient (N = 1) trial to evaluate the efficacy of zolpidem in 48‐year‐old woman with an akinetic mutism. Motor and cognitive examinations functional imaging were performed. Acute administration markedly improved motor performance neuropsychological status. Cerebral metabolism ( 18 F‐fluorodeoxyglucose positron emission tomography) increased postrolandic territories frontal cortex. Using H 2 15 O tomography, we found...
Abstract We sought to define the influence of ageing in clinical, cognitive, and quality‐of‐life outcomes after subthalamic nucleus deep brain stimulation (STN‐DBS) Parkinson's disease (PD). performed motor assessment (UPDRS), mood tests, quality life evaluation (PDQ‐39) on PD patients before surgery, 12 24 months after, we recorded adverse events. The variations these parameters surgery were correlated with age using regression statistical tests. Cerebral bleeding risk was evaluated by a...
Abstract Patients with Parkinson's disease (PD) frequently experience pain that could be in part due to central modification of nociception. In this randomized controlled double blind study, we compared the effect apomorphine versus placebo on thresholds and pain‐induced cerebral activity 25 patients PD. Subjective threshold (using thermal stimulation, thermotest), objective (nociceptive flexion reflex), (H O PET) during noxious innocuous stimulations were performed. Neither subjective nor...
<h3>Objective:</h3> To confirm the efficacy and safety of deep brain stimulation (DBS) internal part globus pallidus in improving severe tardive dyskinesia (TD). <h3>Methods:</h3> Nineteen patients with pharmacoresistant TD were included. All assessed at baseline 3, 6 (main outcome measure), 12 months, long term (6–11 years) for 14 patients, after bilateral pallidal DBS, using motor scales (Extrapyramidal Symptoms Rating Scale [ESRS], Abnormal Involuntary Movement [AIMS]), cognitive scales,...
Abstract Background Effects of DBS on freezing gait and other axial signs in PD patients are unclear. Objective Secondary analysis to assess whether affects these symptoms within a large randomized controlled trial comparing the STN combined with best medical treatment alone early motor complications (EARLYSTIM‐trial). Methods One hundred twenty‐four were stimulation group 127 group. Presence was assessed worst condition based item‐14 UPDRS‐II at baseline follow‐up. The posture, instability,...
Painful sensations are common in Parkinson's disease. In many patients, such correspond to neuropathic pain and could be related central alterations of processing. Subthalamic nuclei deep brain stimulation improves motor function Several structures the basal ganglia involved nociceptive function, thus also modify perception To test this hypothesis, we compared subjective heat thresholds, OFF ON conditions 2 groups disease patients with or without pain. We pain-induced cerebral activations...
After more than 50 years of treating Parkinson's disease with l-DOPA, there are still no guidelines on setting the optimal dose for a given patient. The dopamine transporter type 1, now known as solute carrier family 6 (neurotransmitter transporter), member 3 (SLC6A3) is most powerful determinant neurotransmission and might therefore influence treatment response. We recently demonstrated that methylphenidate (a inhibitor) effective in patients motor gait disorders. objective present study...
Abstract Background Among the different types of pain related to Parkinson's disease (PD), parkinsonian central (PCP) is most disabling. Objectives We investigated analgesic efficacy two therapeutic strategies (opioid with oxycodone‐ prolonged‐release (PR) and higher dose levodopa/benserazide) compared placebo in patients PCP. Methods OXYDOPA was a randomized, double‐blind, double‐dummy, placebo‐controlled, multicenter parallel‐group trial run at 15 centers within French NS‐Park network. PD...
ABSTRACT Objectives The objective of this study was to compare the effect on functional tremor active versus sham repetitive transcranial magnetic stimulation and investigate whether addition hypnosis might help prolong any stimulation–induced therapeutic effect. Methods We compared 5 consecutive daily sessions active/sham tremor, at 1 2 months, in a randomized, double‐blind, 2‐arm, parallel‐controlled study. In second open‐label phase, all patients underwent 3 weekly combined with single...
Freezing of gait (FoG) is a debilitating symptom Parkinson's disease (PD) with limited response to dopaminergic medication and subthalamic deep brain stimulation (STN-DBS). Substantia nigra pars reticulata (SNr) could improve FoG. To analyze the effect combined STN-SNr at different frequencies on We performed double-blind, cross-over, randomized pilot trial involving STN-DBS treated PD patients Participants received: high-frequency (HF) (S), HF-STN SNr (C1), low-frequency (LF) (C2), for one...