A5004016764- Neurobiology of Language and Bilingualism
- Reading and Literacy Development
- Dementia and Cognitive Impairment Research
- Cognitive and developmental aspects of mathematical skills
- EEG and Brain-Computer Interfaces
- Alzheimer's disease research and treatments
- Neural and Behavioral Psychology Studies
- Neuroscience and Music Perception
- Functional Brain Connectivity Studies
- Multisensory perception and integration
- Writing and Handwriting Education
- Health, Medicine and Society
- Action Observation and Synchronization
- Aging, Elder Care, and Social Issues
- Visual perception and processing mechanisms
- Language Development and Disorders
- Face Recognition and Perception
- Neurological disorders and treatments
- Epilepsy research and treatment
- Parkinson's Disease Mechanisms and Treatments
- Neural dynamics and brain function
- Hearing Loss and Rehabilitation
- Cancer-related cognitive impairment studies
- Motor Control and Adaptation
- Memory and Neural Mechanisms
Forschungszentrum Jülich
2024
University Hospital Cologne
2024
University of Cologne
2024
University of Brescia
2024
University of Lausanne
2014-2023
University Hospital of Lausanne
2014-2023
Inserm
2007-2023
French Clinical Research Infrastructure Network
2023
Amyloidosis Foundation
2023
University of Exeter
2021
We assessed brain activation of nine normal right-handed volunteers in a positron emission tomography study designed to differentiate the functional anatomy two major components auditory comprehension language, namely phonological versus lexico-semantic processing. The paradigm included three tasks. In reference task, subjects were asked detect rising pitch within series pure tones. they had monitor sequential phonemic organization non-words. monitored concrete nouns according semantic...
The recognition of dyslexia as a neurodevelopmental disorder has been hampered by the belief that it is not specific diagnostic entity because variable and culture-specific manifestations. In line with this belief, we found Italian dyslexics, using shallow orthography which facilitates reading, performed better on reading tasks than did English French dyslexics. However, all dyslexics were equally impaired relative to their controls phonological tasks. Positron emission tomography scans...
Brain atrophy measured by magnetic resonance structural imaging has been proposed as a surrogate marker for the early diagnosis of Alzheimer's disease. Studies on large samples are still required to determine its practical interest at individual level, especially with regards capacity anatomical disentangle confounding role cognitive reserve in One hundred and thirty healthy controls, 122 subjects mild impairment amnestic type 130 disease patients were included from ADNI database followed up...
One objective of modern neuroimaging is to identify markers that can aid in diagnosis, disease progression monitoring and long-term drug impact analysis. In this study, Parkinson-associated physiopathological modifications were characterized six subcortical structures by simultaneously measuring quantitative magnetic resonance parameters sensitive complementary tissue characteristics (i.e. volume atrophy, iron deposition microstructural damage). Thirty patients with Parkinson's 22 control...
Background: The relationship between phoneme awareness, rapid automatized naming (RAN), verbal short‐term/working memory (ST/WM) and diagnostic category is investigated in control dyslexic children, the extent to which this depends on orthographic complexity. Methods: General cognitive, phonological literacy skills were tested 1,138 1,114 children speaking six different languages spanning a large range of complexity (Finnish, Hungarian, German, Dutch, French, English). Results: Phoneme...
Abstract Reading and writing are crucial life skills but roughly one in ten children affected by dyslexia, which can persist into adulthood. Family studies of dyslexia suggest heritability up to 70%, yet few convincing genetic markers have been found. Here we performed a genome-wide association study 51,800 adults self-reporting diagnosis 1,087,070 controls identified 42 independent significant loci: 15 genes linked cognitive ability/educational attainment, 27 new potentially more specific...
The use of spoken and written language is a fundamental human capacity. Individual differences in reading- language-related skills are influenced by genetic variation, with twin-based heritability estimates 30 to 80% depending on the trait. architecture complex, heterogeneous, multifactorial, but investigations contributions single-nucleotide polymorphisms (SNPs) were thus far underpowered. We present multicohort genome-wide association study (GWAS) five traits assessed individually using...
Voxel-based morphometry was used to assess the consistency among functional imaging and brain data in developmental dyslexia. Subjects, from three different cultural contexts (UK, France Italy), were same as those described a previous PET activation paper, which revealed common pattern of reduced during reading tasks left temporal occipital lobes. We provide evidence that altered observed within system is associated with density grey white matter specific regions, such middle inferior gyri...
Experiments previously reported in the literature suggest that people with dyslexia have a deficit categorical perception. However, it is still unclear whether specific to perception of speech sounds or more generally affects auditory function. In order investigate relationship between and dyslexia, as well nature this categorization deficit, not, discrimination responses children who those average readers sinewave analogues were compared. These presented two different conditions, either...
We previously demonstrated using PET in normal subjects (Demonet et ai, Brain 1992; 115: 1753–68) that, by comparison to a reference task of monitoring for pure tones, phoneme involving two factors complexity (sequence processing and perceptual ambiguity) activated Wernicke's area Broca's area. In the present experiment, we explored respective influence these on brain activation. addition task, four tasks non-words were used with stimuli presented binaurally. These included an easy,...
In 1881, Exner first described a "graphic motor image center" in the middle frontal gyrus. Current psycholinguistic models of handwriting involve conversion abstract, orthographic representations into before sequence appropriate hand movements is produced. Direct cortical stimulation and functional magnetic resonance imaging (fMRI) were used to study human areas involved writing.Cortical electrical mapping was intraoperatively 12 patients during removal brain tumors identify oral language...
Some neuroimaging studies have suggested that specific right hemispheric regions can compensate deficits induced by left lesions in vascular aphasia. In particular, the inferior frontal cortex might take part lexical retrieval patients presenting left-sided involving homologous area.To address whether involvement of is either unique to recovering aphasic or present also other circumstances enrichment abilities, i.e., non-brain-damaged subjects over learning new vocabulary.Ten post-stroke...
In this study, we concurrently investigated 3 possible causes of dyslexia-a phonological deficit, visual stress, and a reduced attention span-in large population 164 dyslexic 118 control French children, aged between 8 13 years old. We found that most children showed either in terms response accuracy (92.1% the sample), speed (84.8%), or both (79.3%). Deficits span, as measured by partial report ability, affected 28.1% participants, all which also deficit. Visual subjective reports...
Abstract Many hypotheses have been proposed about the brain underpinnings of developmental dyslexia, but none them accommodates variable deficits observed. To address issue anatomical in dyslexia; total and partial volumes, lateralization indices (LI), local gray matter volumes (LGMV) were measured. Analyses performed large samples control dyslexic subjects, correlation with their performance on phonological, reading, spelling tests. Results indicate an absence net differences terms...
Modern cochlear implantation technologies allow deaf patients to understand auditory speech; however, the implants deliver only a coarse input and must use long-term adaptive processes achieve coherent percepts. In adults with post-lingual deafness, high progress of speech recovery is observed during first year after implantation, but there large range variability in level implant outcomes temporal evolution recovery. It has been proposed that when profoundly subjects receive implant, visual...
Developmental dyslexia is a specific cognitive disorder in reading acquisition that has genetic and neurological origins. Despite histological evidence for brain differences dyslexia, we recently demonstrated large cohort of subjects, no between control dyslexic readers can be found at the macroscopic level (MRI voxel), because variances local volumes. In present study, aimed finding areas most discriminate from normal despite variance across subjects. After segmenting grey matter,...
Abstract Psychophysical and neuroimaging studies in both animal human subjects have clearly demonstrated that cortical plasticity following sensory deprivation leads to a brain functional reorganization favors the spared modalities. In postlingually deaf patients, use of cochlear implant (CI) allows recovery auditory function, which will probably counteract crossmodal induced by hearing loss. To study dynamics such reversed plasticity, we designed longitudinal involving follow‐up 10 adult CI...