Zhijie Liao
A5064589849- Genetics and Neurodevelopmental Disorders
- Hormonal and reproductive studies
- Functional Brain Connectivity Studies
- Reading and Literacy Development
- Hypothalamic control of reproductive hormones
- Genetic Associations and Epidemiology
- Congenital heart defects research
- Language Development and Disorders
- Stress Responses and Cortisol
- Birth, Development, and Health
- Neurological Disease Mechanisms and Treatments
- Hemispheric Asymmetry in Neuroscience
- Global Educational Reforms and Inequalities
- Primate Behavior and Ecology
- Traditional Chinese Medicine Studies
- Fractal and DNA sequence analysis
- Evolutionary Psychology and Human Behavior
- Genomics and Rare Diseases
- Health, Environment, Cognitive Aging
- Mitochondrial Function and Pathology
- Radiomics and Machine Learning in Medical Imaging
- Cognitive and developmental aspects of mathematical skills
- Traumatic Brain Injury and Neurovascular Disturbances
- Face Recognition and Perception
- Diverse Education Studies and Reforms
Centre Hospitalier Universitaire Sainte-Justine
2023-2025
Université de Montréal
2023-2024
University of Toronto
2020-2023
Holland Bloorview Kids Rehabilitation Hospital
2020-2021
Sun Yat-sen University
2017
Nanfang Hospital
2008
Abstract Reading and writing are crucial life skills but roughly one in ten children affected by dyslexia, which can persist into adulthood. Family studies of dyslexia suggest heritability up to 70%, yet few convincing genetic markers have been found. Here we performed a genome-wide association study 51,800 adults self-reporting diagnosis 1,087,070 controls identified 42 independent significant loci: 15 genes linked cognitive ability/educational attainment, 27 new potentially more specific...
The use of spoken and written language is a fundamental human capacity. Individual differences in reading- language-related skills are influenced by genetic variation, with twin-based heritability estimates 30 to 80% depending on the trait. architecture complex, heterogeneous, multifactorial, but investigations contributions single-nucleotide polymorphisms (SNPs) were thus far underpowered. We present multicohort genome-wide association study (GWAS) five traits assessed individually using...
The tangential expansion of the human cerebral cortex, indexed by its surface area (SA), occurs mainly during prenatal and early postnatal periods, is influenced genetic factors. Here we investigate role rare copy number variants (CNVs) in shaping SA, underlying mechanisms, aggregating CNVs across genome community-based cohorts (N = 39,015). We reveal that genome-wide CNV deletions duplications are associated with smaller SA. Subsequent analyses gene expression fetal cortex suggest influence...
The social relationships that individuals experience at different life stages have a non-negligible influence on their lives, and this is particularly true for group living animals. long lifespan of many primates makes it likely these animals various tactics interaction to adapt complex changes in environmental or physical conditions. strategies used by stages, whether the position (central peripheral) role (initiator recipient) an individual network with age, are intriguing questions remain...
Prenatal stress influences brain development and mood disorder vulnerability. Brain structural covariance network (SCN) properties based on inter-regional volumetric correlations may reflect developmentally-mediated shared plasticity among regions. Childhood trauma is associated with amygdala-centric SCN reorganization patterns, however, the impact of prenatal remains unknown. The study included participants from European Longitudinal Study Pregnancy (ELSPAC) archival data MRI acquired in...
<h3>Importance</h3> Nonverbal learning disability (NVLD) is a neurodevelopmental disorder characterized by deficits in visual-spatial processing but not reading or verbal ability; addition, problems math calculation, visual executive functioning, fine-motor skills, and social skills are often present. To our knowledge, there no population-based estimates of the prevalence NVLD community samples. <h3>Objective</h3> estimate cognitive profile 3 independent samples children adolescents from...
Abstract Adolescence is a period of brain maturation that may involve second wave organizational effects sex steroids on the brain. Rodent studies suggest that, overall, gonadal steroid hormones decrease from prenatal/perinatal to adulthood. Here we used multimodal magnetic resonance imaging investigate whether 1) testosterone exposure during adolescence (9–17 years) correlates with structure cerebral cortex in young men (n = 216, 19 years age); 2) this relationship modulated by timing surge...
Abstract The use of spoken and written language is a capacity that unique to humans. Individual differences in reading- language-related skills are influenced by genetic variation, with twin-based heritability estimates 30-80%, depending on the trait. relevant architecture complex, heterogeneous, multifactorial, yet be investigated well-powered studies. Here, we present multicohort genome-wide association study (GWAS) five traits assessed individually using psychometric measures: word...
Abstract Context Sex hormone-binding globulin (SHBG) is associated with levels of total testosterone (total-T), and both total-T SHBG are obesity. Objective We aimed to clarify the nature relationship between improve our understanding their relationships hypothesize that hypothalamic-pituitary-gonadal axis contributes homeostasis by increasing production gonadal through a feedback mechanism might operate differently at different pubertal stages. Methods investigated dynamics SHBG, total-T,...
Hemispheric lateralization and its origins have been of great interest in neuroscience for over a century. The left–right asymmetry cortical thickness may stem from differential maturation the cerebral cortex two hemispheres. Here, we investigated spatial pattern hemispheric differences thinning during adolescence, relationship with density neurotransmitter receptors homotopic functional connectivity. Using longitudinal data IMAGEN study (N = 532), found that many regions frontal temporal...
According to the organizational-activational hypothesis, organizational effects of testosterone during (prenatal) brain development moderate activational adult on behavior. Accumulating evidence supports notion that adolescence is another period which sex hormones organize nervous system. Here we investigate how pubertal social cognition in humans. To do so, recruited a sample young men ( n = 507; age, ∼19 years) from longitudinal birth cohort and investigated whether exposure (from 9 17...
The ability to extract cues from faces is fundamental for social animals, including humans. An individual's profile of functional connectivity across a face network can be shaped by common organizing principles, stable individual traits, and time-varying mental states. In the present study, we used data obtained with magnetic resonance imaging in two cohorts, IMAGEN (N = 534) ALSPAC 465), investigate - both at group levels consistency regional populations (IMAGEN, ALSPAC) time (Visits 1 3...