A5086976809- Genetics and Neurodevelopmental Disorders
- Reading and Literacy Development
- Attachment and Relationship Dynamics
- Child and Adolescent Psychosocial and Emotional Development
- Language Development and Disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Veterinary Practice and Education Studies
- Autism Spectrum Disorder Research
- Cognitive and developmental aspects of mathematical skills
- Genetic Associations and Epidemiology
- Congenital heart defects research
- Agriculture and Farm Safety
- Education Methods and Practices
- Diverse Educational Innovations Studies
- Parental Involvement in Education
- Cardiomyopathy and Myosin Studies
- Cardiac Valve Diseases and Treatments
- Diverse Education Studies and Reforms
- Child Abuse and Trauma
- Ethics in medical practice
- Human-Animal Interaction Studies
- Psychotherapy Techniques and Applications
- Musculoskeletal pain and rehabilitation
- Child Development and Digital Technology
- Cardiac Arrhythmias and Treatments
University of Guelph
2023-2025
Hospital for Sick Children
1996-2023
SickKids Foundation
2011
University of Toronto
2009
University of Rochester
2009
Abstract Reading and writing are crucial life skills but roughly one in ten children affected by dyslexia, which can persist into adulthood. Family studies of dyslexia suggest heritability up to 70%, yet few convincing genetic markers have been found. Here we performed a genome-wide association study 51,800 adults self-reporting diagnosis 1,087,070 controls identified 42 independent significant loci: 15 genes linked cognitive ability/educational attainment, 27 new potentially more specific...
The use of spoken and written language is a fundamental human capacity. Individual differences in reading- language-related skills are influenced by genetic variation, with twin-based heritability estimates 30 to 80% depending on the trait. architecture complex, heterogeneous, multifactorial, but investigations contributions single-nucleotide polymorphisms (SNPs) were thus far underpowered. We present multicohort genome-wide association study (GWAS) five traits assessed individually using...
The data for 197 mother–infant pairs from two longitudinal studies were analyzed to assess relations between maternal attachment representations; atypical behavior, coded with a new tool, Atypical Maternal Behavior Instrument Assessment and Classification (AMBIANCE), infant attachment. Both systematically related behavior: mothers who Unresolved on the Adult Attachment Interview those whose infants disorganized in Strange Situation Procedure engaged more behaviors than not showed organized...
Abstract Although central to attachment theory, internal working models remain a useful heuristic in need of concretization. We compared the selective attention organized and disorganized mothers using emotional Stroop task. Both response involve coordination strongly conflicting motivations under conditions arousal. Furthermore, much is known about cognitive neuromodulatory correlates that may inform attempts substantiate model construct. assessed 47 community with Adult Attachment...
Reading disabilities (RD) are the most common neurocognitive disorder, affecting 5% to 17% of children in North America. These often have comorbid neurodevelopmental/psychiatric disorders, such as attention deficit/hyperactivity disorder (ADHD). The genetics RD and their overlap with other disorders is incompletely understood. To contribute this, we performed a genome-wide association study (GWAS) for word reading. Then, using summary statistics from computed polygenic risk scores (PRS) used...
To describe veterinary professionals' perceptions of relational coordination (RC) within their hospital and examine associations with perceived workplace psychological climate, job satisfaction, intention to leave. All 4,676 employees working in 136 corporate-owned hospitals were invited respond an online survey. Measures included employees' regarding RC, leave hospital. Ordinal logistic regressions examined between RC each the aforementioned variables. 578 from 114 participated....
Developmental dyslexia (DD) is a common reading disability, affecting 5% to 11% of children in North America. Children classified as having DD often have history early language delay (ELD) or impairments. Nevertheless, studies reported conflicting results the association between DD-ELD and extent current difficulties with DD. To examine these relationships, we queried parents school-age on their child’s ability. Siblings were also examined. directly assessed using quantitative tests skills....
Abstract The use of spoken and written language is a capacity that unique to humans. Individual differences in reading- language-related skills are influenced by genetic variation, with twin-based heritability estimates 30-80%, depending on the trait. relevant architecture complex, heterogeneous, multifactorial, yet be investigated well-powered studies. Here, we present multicohort genome-wide association study (GWAS) five traits assessed individually using psychometric measures: word...
The current study: (1) examined the relation between therapeutic alliance and changes in adolescent externalizing behavior Multisystemic Therapy; (2) tested whether maternal depression mediates this relation; (3) determined mothers' clinicians' perceptions of differentially predicted outcomes. Alliance was rated near end first month treatment. At pre-, mid- posttreatment, adolescents' were assessed via mother reports, by clinicians at pre- posttreatment only. Mediational analyses showed that...
Abstract Neuroimaging studies implicate multiple cortical regions in reading ability/disability. However, the neural cell types integral to process are unknown. To contribute this gap knowledge, we integrated genetic results from genome-wide association for word (n = 5054) with gene expression datasets adult/fetal human brain. Linkage disequilibrium score regression (LDSC) suggested that variants associated were enriched genes expressed adult excitatory neurons, specifically layer 5 and 6...
Abstract OBJECTIVE To classify a sample of veterinary professionals into distinct organizational-commitment profiles and to identify associations between psychosocial aspects the workplace profile membership. SAMPLE 487 employees who worked for corporate organization in Canada. METHODS Survey components measured this study included Three-Component Model (TCM) Employee Commitment Survey–Revised, Copenhagen Psychosocial Questionnaire, participant demographics. First, latent analysis was used...
Abstract OBJECTIVE To describe burden transfer in a sample of veterinary workers employed by Canadian corporation and to examine the association between different levels employee burnout perceived psychosocial work environment. SAMPLE 475 employees small-animal hospitals owned corporate practice group. METHODS Veterinary team members among 14 working groups responded an online survey that included assessments transfer, environment, within workplace. Participants were divided into on basis...
Background: Reading disabilities (RD) are the most common learning disabilities, affecting 3-7% of school-aged children in North America. RD is associated with increased risk for comorbid language-based disorders including early language delay (ELD), speech sound disorders, and impairments. Despite decades research on relationship between these questions remain as to strength their associations. This study first this size assess all four a sample RD. Method: We examined association large,...