A5087073377- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Long-Term Effects of COVID-19
- Lysosomal Storage Disorders Research
- Parkinson's Disease and Spinal Disorders
- Restless Legs Syndrome Research
- Dysphagia Assessment and Management
- COVID-19 Clinical Research Studies
- Cellular transport and secretion
- Peripheral Neuropathies and Disorders
- Transcranial Magnetic Stimulation Studies
- Autism Spectrum Disorder Research
- Functional Brain Connectivity Studies
- Balance, Gait, and Falls Prevention
- Genetic Neurodegenerative Diseases
- EEG and Brain-Computer Interfaces
- Pharmaceutical industry and healthcare
- COVID-19 and healthcare impacts
- Genomic variations and chromosomal abnormalities
- Congenital heart defects research
- COVID-19 and Mental Health
- Cardiovascular Syncope and Autonomic Disorders
- Retinal and Optic Conditions
- Studies on Chitinases and Chitosanases
University of Turin
2021-2025
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2021-2025
Piedmont Reference Center for Epidemiology and Cancer Prevention
2022-2023
Neurology, Inc
2021
Background GBA variants increase the risk of developing Parkinson disease (PD) and influence its outcome. Deep brain stimulation (DBS) is a recognised therapeutic option for advanced PD. Data on DBS long-term outcome in carriers are scarce. Objective To elucidate impact large Italian cohort. Methods We retrospectively recruited multicentric DBS-PD cohort assessed: (1) prevalence; (2) pre-DBS clinical features; (3) outcomes motor, cognitive other non-motor features up to 5 years post-DBS....
Botulinum toxin (BoNT) is a valuable treatment in movement disorders; however, time to onset and duration of efficacy may widely differ among patients. We aimed clarify the impact main demographic clinical features on BoNT efficacy.We analyzed time-to-onset 186 consecutive patients treated with for blepharospasm, cervical dystonia, facial hemispasm, oromandibular limb sialorrhea due Parkinsonism. The following factors were considered as potential predictors: doses types toxin, sex, age,...
Gait issues, including reduced speed, stride length and freezing of gait (FoG), are disabling in advanced phases Parkinson's disease (PD), their treatment is challenging. Levodopa/carbidopa intestinal gel (LCIG) can improve these symptoms PD patients with suboptimal control motor fluctuations, but it unclear if continuous dopaminergic stimulation further independently from reducing Off-time.
Freezing of gait (FoG) is a debilitating symptom Parkinson's disease (PD) with limited response to dopaminergic medication and subthalamic deep brain stimulation (STN-DBS). Substantia nigra pars reticulata (SNr) could improve FoG. To analyze the effect combined STN-SNr at different frequencies on We performed double-blind, cross-over, randomized pilot trial involving STN-DBS treated PD patients Participants received: high-frequency (HF) (S), HF-STN SNr (C1), low-frequency (LF) (C2), for one...
Treatment of freezing gait (FoG) and other Parkinson disease (PD) axial symptoms is challenging. Systematic assessments at progressively increasing levodopa doses are lacking. We sought to analyze the resistance high FoG, posture, speech, altered features presenting in daily-ON therapeutic condition.We performed a pre-/postinterventional study including patients treated with levodopa/carbidopa intestinal gel infusion (LCIG) disabling FoG condition. Patients were evaluated their usual LCIG...
Lateral trunk flexion (LTF) and its severe form, called Pisa syndrome (PS), are highly invalidating axial postural abnormalities associated with Parkinson’s disease (PD). Management strategies for LTF lack strong scientific evidence. We present a real-life, longitudinal study evaluating long-term efficacy of botulinum toxin (BoNT) injections in muscles to reduce PS PD. A total 13 PD patients > 5° received ultrasound- electromyography-guided BoNT every 4 months. Seven untreated matched...
We sought to estimate the impact of cardiovascular autonomic neuropathy (cAN) on informal caregivers patients with Parkinson's disease (PD), defined as individuals providing regular care a friend, partner, or family member PD, and evaluate mutual relationship between caregiver burden patient health-related quality life (HRQoL).We enrolled 36 consecutive PD their caregivers. Patients underwent detailed motor, autonomic, cognitive, functional assessment. Caregivers were assessed using Zarit...
<title>Abstract</title> Background Freezing of gait (FoG) is a debilitating symptom Parkinson's disease (PD) with limited response to dopaminergic medication and subthalamic deep brain stimulation (STN-DBS). Substantia nigra pars reticulata (SNr) could improve FoG. Objectives To analyze the effect combined STN-SNr at different frequencies on Methods We performed double-blind, cross-over, randomized pilot trial involving STN-DBS treated PD patients Participants received: high-frequency (HF)...