Luca Magistrelli
A5056244345- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Genetic Neurodegenerative Diseases
- Nuclear Receptors and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Alzheimer's disease research and treatments
- Cerebral Palsy and Movement Disorders
- Transcranial Magnetic Stimulation Studies
- Neurological diseases and metabolism
- Dysphagia Assessment and Management
- Parkinson's Disease and Spinal Disorders
- RNA regulation and disease
- Genomics and Rare Diseases
- Medical Imaging and Pathology Studies
- Stroke Rehabilitation and Recovery
- Attention Deficit Hyperactivity Disorder
- Tryptophan and brain disorders
- Pain Mechanisms and Treatments
- Thyroid and Parathyroid Surgery
- Cancer Diagnosis and Treatment
- Muscle activation and electromyography studies
- Hereditary Neurological Disorders
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2015-2024
Azienda Ospedaliero Universitaria Maggiore della Carita
2022-2024
Istituto Ortopedico Gaetano Pini
2024
University of Insubria
2019-2023
John Wiley & Sons (United States)
2023
National Hospital for Neurology and Neurosurgery
2020
University College London
2020
Parkinson's disease (PD) affects an estimated 7 to 10 million people worldwide, and only symptomatic treatments are presently available relieve the consequences of brain dopaminergic neurons loss. Neuronal degeneration in PD is consequence neuroinflammation turn influenced by peripheral adaptive immunity, with CD4+ T lymphocytes playing a key role. cells may however acquire proinflammatory phenotypes, such as helper (Th) 1 Th17, well anti-inflammatory Th2 regulatory (Treg) one, what extent...
Background: Parkinson's disease (PD) is characterized by loss of dopaminergic neurons and intraneuronal accumulation alpha-synuclein, both in the basal ganglia peripheral sites, such as gut. Peripheral immune activation reactive oxygen species (ROS) production are important pathogenetic features PD. In this context, present study focused on assessment vitro effects probiotic bacterial strains PD patients versus healthy controls. Methods: we enrolled 40 matched blood mononuclear cells (PBMCs)...
Abstract Introduction The recently released classification has revised the nosology of tremor, defining essential tremor (ET) as a syndrome and fueling an enlightened debate about some newly conceptualized entities such ET-plus. As result, precise information demographics, clinical features, natural history these conditions are lacking. Methods ITAlian Network (TITAN) is multicenter data collection platform, aim which to prospectively assess, according standardized protocol, phenomenology...
Effects of dopaminergic medications used to treat Parkinson's disease (PD) may be compared with each other by using conversion factors, calculated as Levodopa equivalent dose (LED). However, current LED proposals on MAO-B inhibitors (iMAO-B) safinamide and rasagiline are still based empirical approaches.To estimate 50 100 mg.In this multicenter, longitudinal, case-control study, we retrospectively reviewed clinical charts 500 consecutive PD patients motor complications treated (i) mg (N =...
Abstract Background Tremor disorders remain as clinical diagnoses and the rate of misdiagnosis between commonest non‐parkinsonian tremors is relatively high. Objectives To compare features Essential without other (pure ET), ET plus soft dystonic signs (ET + DS), tremor combined with dystonia (TwD). Methods We compared patients pure ET, DS, TwD enrolled in The ITAlian Network (TITAN). Linear regression models were performed to determine factors associated health status quality life. Results...
Background: Knee osteoarthritis is a prevalent condition that significantly impacts patients’ quality of life. Effective management typically involves combination pharmacological and non-pharmacological treatments. However, establishing consensus on the optimal treatment strategy crucial for standardizing care. The present study result rigorous process combines artificial intelligence with human expertise to improve reliability medical recommendations. Methods: A new software platform...
Abstract Background CD4+ T‐cell dysregulation occurs in Parkinson's disease (PD); however, it is unknown whether contributes to PD development. The objective of this study was investigate transcription factor gene expression T cells idiopathic rapid eye movement sleep behavior disorder, the strongest risk for prodromal PD. Methods Expression factors ( TBX21 , STAT1 STAT3 STAT4 STAT6 RORC GATA3 FOXP3 and NR4A2 ) measured from 33 polysomnographically confirmed disorder subjects compared with...
L-dopa-induced dyskinesia (LID) is a frequent motor complication of Parkinson's disease (PD), associated with negative prognosis. Previous studies showed an association between dopamine receptor (DR) gene variants and LID, the results which have not been confirmed. The present study aimed to determine whether genetic differences DR are LID in small but well-characterized cohort PD patients. To this end we enrolled 100 subjects, 50 without matched for age, gender, duration dopaminergic...
Lymphocyte count and neutrophil-to-lymphocyte ratio (NLR) may represent useful biomarkers of Parkinson's disease (PD), but their role in PD-related mild cognitive impairment (MCI) has not been fully elucidated. The present study aimed to confirm whether these immunological measures can discriminate PD patients from healthy controls (HC) establish feasibility as prognostic MCI PD. Immunological data at baseline were analyzed 58 drug-naïve HC matched 1:1 for age, sex, cardiovascular...
Background Several earlier studies showed a female predominance in idiopathic adult-onset dystonia (IAOD) affecting the craniocervical area and male preponderance limb dystonia. However, sex-related differences may result from bias inherent to study design. Moreover, information is lacking on whether exist expressing other dystonia-associated features spread. Objective To provide accurate relationship between sex differences, motor phenomenology, natural history of IAOD. Methods Data 1701...
Background: α-synuclein is a constituent of Lewy bodies and mutations its gene cause familial Parkinson's Disease (PD). A previous study showed that variant the (SNCA), namely 263bp allele Rep1 was associated to faster motor progression in PD. On contrary, recent report failed detect detrimental effect 263 on both cognitive outcomes Aim this evaluate influence variants disease PD patients. Methods: We recruited genotyped for SNCA-Rep1 426 patients with age at onset ≥ 40 years duration 4...