A5070963688- Neonatal Health and Biochemistry
- Neonatal Respiratory Health Research
- Hematopoietic Stem Cell Transplantation
- Mesenchymal stem cell research
- Neonatal and fetal brain pathology
- Hemoglobinopathies and Related Disorders
- Blood groups and transfusion
- Retinopathy of Prematurity Studies
- Angiogenesis and VEGF in Cancer
- Erythrocyte Function and Pathophysiology
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood transfusion and management
- Periodontal Regeneration and Treatments
- CAR-T cell therapy research
- Platelet Disorders and Treatments
- Transplantation: Methods and Outcomes
- Genital Health and Disease
- Trauma and Emergency Care Studies
- Pancreatic function and diabetes
- Acute Myeloid Leukemia Research
- Blood donation and transfusion practices
- Neurological and metabolic disorders
- Psychotherapy Techniques and Applications
- Immune cells in cancer
- Prenatal Screening and Diagnostics
Istituti di Ricovero e Cura a Carattere Scientifico
2002-2025
Agostino Gemelli University Polyclinic
2017-2025
Università Cattolica del Sacro Cuore
2009-2025
Azienda Ospedaliero Universitaria Ospedali Riuniti
2024
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2022-2024
Azienda Ospedaliera Universitaria Pisana
2024
Azienda ospedaliera "Bianchi-Melacrino-Morelli"
2022
Casa Sollievo della Sofferenza
2022
Bambino Gesù Children's Hospital
2021
Universitätsklinikum Würzburg
2020
Abstract Background Preterm infants are at high risk for retinopathy of prematurity (ROP), with potential life-long visual impairment. Low fetal hemoglobin (HbF) levels predict ROP. It is unknown if preventing the HbF decrease also reduces Methods BORN an ongoing multicenter double-blinded randomized controlled trial investigating whether transfusing HbF-enriched cord blood-red blood cells (CB-RBCs) instead adult donor-RBC units (A-RBCs) incidence severe ROP (NCT05100212). Neonates born...
Repeated red blood cell (RBC) transfusions in preterm neonates are associated with poor outcome and increased risk for prematurity-associated diseases. RBC cause the progressive replacement of fetal haemoglobin (HbF) by adult (HbA). We monitored HbF levels 25 until 36 weeks post-menstrual age (PMA); patients received units from allogeneic cord (cord-RBCs) or donors (adult-RBCs), depending on whether cord-RBCs were available. Primary was level at PMA 32 weeks. Twenty-three survived this age:...
Abstract Background Extremely low gestational age neonates (ELGANs, i.e., born before 28 weeks of gestation) are at high risk developing retinopathy prematurity (ROP), with potential long-life visual impairment. Due to concomitant anemia, ELGANs need repeated red blood cell (RBC) transfusions. These produce a progressive replacement fetal hemoglobin (HbF) by adult (HbA). Furthermore, close association exists between levels HbF and severe ROP, suggesting that perturbation the HbF-mediated...
Repeated red blood cell (RBC) transfusions are thought to increase the risk for retinopathy of prematurity (ROP), likely due a critical fetal hemoglobin (HbF) reduction. In this study, we investigated if postmenstrual age (PMA) neonates at transfusion influences ROP. We estimated cumulative transfusion-free survival (TFS) in series 100 preterm receiving one or more RBC units. TFS was calculated by censoring patients first and expressing time between birth as either PMA postnatal day. Then,...
Our objective is to determine the protein and complements constituents of Cord blood Platelet-rich plasma (CB-PRP), based on hypothesis that it contains beneficial components capable arresting or potentially decelerating advancement atrophic age-related macular degeneration (dry-AMD), with support radiomics. Two distinct pools CB-PRP were assessed, each pool obtained from a total 15 umbilical cord-blood donors. One aliquot respectively was subjected proteomic analysis in order enhance...
Intravitreal injections (IVIs) of umbilical cord blood platelet-rich plasma (CB-PRP) were investigated to assess their safety and efficacy in slowing the progression atrophy eyes with late-stage dry age-related macular degeneration (AMD). Randomized, controlled, prospective study. Patients AMD aged >65 years diagnosed bilateral geographic enrolled. One eye each subject received treatment intravitreal CB-PRP 0.05 ml, while fellow a sham injection. Atrophic areas identified as large choroidal...
L-dopa-induced dyskinesia (LID) is a frequent motor complication of Parkinson's disease (PD), associated with negative prognosis. Previous studies showed an association between dopamine receptor (DR) gene variants and LID, the results which have not been confirmed. The present study aimed to determine whether genetic differences DR are LID in small but well-characterized cohort PD patients. To this end we enrolled 100 subjects, 50 without matched for age, gender, duration dopaminergic...
<b><i>Background:</i></b> Preterm infants often receive blood transfusions early in life. In this setting, umbilical cord (UCB) might be safer than adult (A) with respect to infectious and immunologic threats. <b><i>Objectives:</i></b> To evaluate, as a first objective, the feasibility of fulfilling transfusion needs preterm allogeneic UCB red cell (RBC) concentrates and, secondary assess safety transfusions....
Pure red cell aplasia (PRCA) is a possible complication after allogeneic hematopoietic stem transplantation (HSCT) with major ABO incompatibility. Patients experience delayed engraftment of the erythroid series, prolonged transfusion-dependent anemia and iron overload.
We retrospectively investigated the incidence and risk factors for transfusion-related acute lung injury (TRALI) among patients transfused post-partum hemorrhage (PPH).We identified a series of 71 consecutive with PPH requiring urgent transfusion three or more red blood cell (RBC) units, without fresh frozen plasma (FFP) and/or platelets (PLT). Clinical records were then retrieved examined respiratory distress events. According to 2004 consensus definition, cases new-onset hypoxemia, within...
Endothelial colony-forming cells (ECFC) are endowed with vascular regenerative ability in vivo and vitro. In this study we compared the genotypic profile immunogenic potential of adult cord blood ECFC, order to explore feasibility using them as a cell therapy product.ECFC were obtained from samples not suitable for haematopoietic stem transplantation healthy donors after informed consent. Genotypes analysed by commercially available microarray assays results confirmed real-time polymerase...
von Hippel-Lindau Disease and Erythrocytosis Case ReportA 37-year-old man, who complained about a headache, nausea, vomiting, was referred to our hospital.From childhood, the patient presented with erythrocytosis secondary high erythropoietin level.This persisting increased level not associated cardiopulmonary renal diseases, tumors, or hemoglobinopaties.Since age of 7 years, treated periodic phlebotomies low-dose aspirin.Furthermore, at 30 underwent surgery for welldifferentiated...
Platelet-rich plasma (PRP) is an inexpensive and safe substitute of recombinant growth factors in Vitro vivo. Due to its putative effect on tissue repair, the use autologous PRP has become largely popular. Recently, a jellified derivative obtained from umbilical cord blood (CB) been utilized vivo treat mucosal cutaneous lesions. Nevertheless, whether derived CB adult display different potency promoting cell rarely investigated. In this study, we compared cytokine profile mesenchymal...
The SIMS-Trial showed that the 'Sapere Migliora' information aid (IA) for newly diagnosed people with multiple sclerosis (PwMS) effectively improved patient knowledge and satisfaction care.The objectives of this paper are to assess effectiveness IA in clinical practice compare whole take-home booklet/website component alone.After updating replacing CD a website, prospective, open-label non-randomised controlled trial compared (group A, five centres) B, 16 centres). One month after...