A5004872259- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Immune Cell Function and Interaction
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Multiple Sclerosis Research Studies
- Cannabis and Cannabinoid Research
- Stress Responses and Cortisol
- Nuclear Receptors and Signaling
- Neuroscience of respiration and sleep
- Cancer, Stress, Anesthesia, and Immune Response
- Pain Mechanisms and Treatments
- Academic integrity and plagiarism
- Atherosclerosis and Cardiovascular Diseases
- Diet and metabolism studies
- Gastrointestinal motility and disorders
- Sleep and Wakefulness Research
- Chemokine receptors and signaling
- Adipokines, Inflammation, and Metabolic Diseases
- Obstructive Sleep Apnea Research
- Immunotherapy and Immune Responses
- Pharmacological Receptor Mechanisms and Effects
- SARS-CoV-2 and COVID-19 Research
University of Insubria
2016-2025
Ospedale Civile di Venezia
2024
Istituto di Farmacologia Traslazionale
2020
Ferrari (Italy)
2020
Medica (United States)
2020
Istituto Centrale per il Catalogo Unico delle Biblioteche Italiane e per le Informazioni Bibliografiche
2020
Ospedale San Carlo
2016
GTx (United States)
2008
University of Pavia
1996-2005
Fondazione Salvatore Maugeri
2005
Parkinson's disease (PD) affects an estimated 7 to 10 million people worldwide, and only symptomatic treatments are presently available relieve the consequences of brain dopaminergic neurons loss. Neuronal degeneration in PD is consequence neuroinflammation turn influenced by peripheral adaptive immunity, with CD4+ T lymphocytes playing a key role. cells may however acquire proinflammatory phenotypes, such as helper (Th) 1 Th17, well anti-inflammatory Th2 regulatory (Treg) one, what extent...
Abstract Parkinson’s disease (PD) is characterized by loss of dopaminergic neurons in substantia nigra pars compacta, α-synuclein (α-syn)-rich intraneuronal inclusions (Lewy bodies), and microglial activation. Emerging evidence suggests that CD4+ T lymphocytes contribute to neuroinflammation PD. Since the mainstay PD treatment substitution therapy dopamine an established transmitter connecting nervous immune systems, we examined naive memory patients healthy subjects (HS), with specific...
Coronavirus disease-19 (COVID-19) mRNA vaccines are the mainstays of mass vaccination campaigns in most Western countries. However, emergency conditions which their development took place made it impossible to fully characterize effects and mechanism action. Here, we summarize discuss available evidence indicating that COVID-19 better reflect pharmaceutical drugs than conventional vaccines, as they do not contain antigens but an active SARS-CoV-2 S protein mRNA, representing at same time...
Radioiodine (RAI) therapy may cause progression of mild or absent Graves' orbitopathy (GO), preventable by oral prednisone. Optimal doses prednisone are undefined.The aim this study was to compare the effectiveness reported [starting dose, >0.3 mg/kg body weight (bw)], and lower (<0.3 bw)] prednisone.We conducted a retrospective matched cohort at University Center.Of 111 RAI-treated patients with no GO, 35 received steroid prophylaxis (absence GO and/or risk factors for RAI-associated...
Hypertension is a frequent finding in elderly patients. older age can be both associated with frailty and represent risk factor for frailty. recognized as main cardiovascular diseases such heart failure, atrial fibrillation, stroke the occurrence of these may provoke decline health status and/or worsen degree Blood pressure targets hypertensive frail patients are not completely defined. However, specific evaluations individual their co-morbidities assessment domains components frailty,...
Objectives Polymorphonuclear neutrophils (PMN) in atherosclerotic plaques have been identified only recently, and their contribution to plaque development is not yet fully understood. In this study, production of elastase, interleukin (IL)-8 vascular endothelial growth factor (VEGF) by PMN was investigated subjects with carotid stenosis undergoing endarterectomy (CEA). Methods The study enrolled 50 patients (Pts) 10 healthy (HS). Circulating (cPMN) isolated from venous blood (in both Pts HS)...