A5058227578- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
- Genetic Neurodegenerative Diseases
- Autism Spectrum Disorder Research
- Neurological diseases and metabolism
- Botulinum Toxin and Related Neurological Disorders
- Alzheimer's disease research and treatments
- Cellular transport and secretion
- Genetics and Neurodevelopmental Disorders
- Mitochondrial Function and Pathology
- Dysphagia Assessment and Management
- Child Nutrition and Feeding Issues
- Hereditary Neurological Disorders
- Neuroscience and Neural Engineering
- Cerebral Palsy and Movement Disorders
- Genomics and Rare Diseases
- RNA regulation and disease
- Organic Light-Emitting Diodes Research
- Glycogen Storage Diseases and Myoclonus
- Lysosomal Storage Disorders Research
- Conducting polymers and applications
- Cell Adhesion Molecules Research
- Nerve injury and regeneration
Istituto Ortopedico Gaetano Pini
2024-2025
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2020-2024
John Wiley & Sons (United States)
2023
Centre for Movement Disorders
2021
Arcispedale Sant'Anna
2019
University of Ferrara
2018
Effects of dopaminergic medications used to treat Parkinson's disease (PD) may be compared with each other by using conversion factors, calculated as Levodopa equivalent dose (LED). However, current LED proposals on MAO-B inhibitors (iMAO-B) safinamide and rasagiline are still based empirical approaches.To estimate 50 100 mg.In this multicenter, longitudinal, case-control study, we retrospectively reviewed clinical charts 500 consecutive PD patients motor complications treated (i) mg (N =...
Abstract Background Tremor disorders remain as clinical diagnoses and the rate of misdiagnosis between commonest non‐parkinsonian tremors is relatively high. Objectives To compare features Essential without other (pure ET), ET plus soft dystonic signs (ET + DS), tremor combined with dystonia (TwD). Methods We compared patients pure ET, DS, TwD enrolled in The ITAlian Network (TITAN). Linear regression models were performed to determine factors associated health status quality life. Results...
Abstract Introduction The recently released classification has revised the nosology of tremor, defining essential tremor (ET) as a syndrome and fueling an enlightened debate about some newly conceptualized entities such ET-plus. As result, precise information demographics, clinical features, natural history these conditions are lacking. Methods ITAlian Network (TITAN) is multicenter data collection platform, aim which to prospectively assess, according standardized protocol, phenomenology...
Poly-ADP-ribosylation (PARylation), catalyzed by the enzyme PARP1, involves addition of poly-ADP-ribose polymers (PAR) and has been associated with α-synuclein aggregation in Parkinson′s disease (PD) models. This study aimed to unravel role PARylation neuronal cell death complex environment post-mortem human PD brains. Using high-resolution imaging 3D reconstruction analysis, we observed that PAR accumulate cytoplasm regions affected pathology, preceding formation oligomers. Additionally,...
<title>Abstract</title> Background Spinocerebellar ataxia type 1 (SCA1) is characterised by motor and cognitive symptoms. Sex-specific differences in disease presentation progression remain poorly understood. This study investigates the role of sex clinical-demographic motor/cognitive outcomes SCA1. Methods single-centre, longitudinal observational cohort was conducted at University Hospital Ferrara between 2021 2024. Consecutively, genetically confirmed SCA1 patients were evaluated baseline...
Lymphocyte count and neutrophil-to-lymphocyte ratio (NLR) may represent useful biomarkers of Parkinson's disease (PD), but their role in PD-related mild cognitive impairment (MCI) has not been fully elucidated. The present study aimed to confirm whether these immunological measures can discriminate PD patients from healthy controls (HC) establish feasibility as prognostic MCI PD. Immunological data at baseline were analyzed 58 drug-naïve HC matched 1:1 for age, sex, cardiovascular...
Background. Matrix metalloproteinases (MMPs) are pleiotropic enzymes involved in extracellular protein degradation and turnover. MMPs implicated the pathogenesis of many neurological diseases, including multiple sclerosis (MS). Objective. To search level cerebrospinal fluid (CSF) MS patients detect possible disease-specific patterns. Methods. CSF samples from 32 and, 22 control subjects with other diseases (OND) were analysed. The Bio-Plex Pro Human MMP 9-Plex Panel (Bio-Rad) was used for...
Abstract Background Parkinson's disease (PD) is a chronic, progressive neurodegenerative condition that gradually worsens motor function and leads to postural instability and, eventually, falls. Several factors may influence the frequency of future falls, such as slowness, freezing gait, loss balance, mobility problems, cognitive impairments, number previous The TED bracelet an advanced technological wearable device able predict Aims This principal aim investigate feasibility full-scale...
Management of motor complications (MC) represents a major challenge in the long-term treatment Parkinson's disease (PD) patients. In this context, role peripheral adaptive immunity may provide new insights, since neuroinflammatory mechanisms have been proved crucial disease.The aim study was to analyze transcription factors genes involved CD4 + T cells development uncover specific molecular signatures patients with (PMC) and without (WMC) complications.mRNA levels lymphocytes factor TBX21,...
Event-related potentials (ERPs) reflect cognitive processing: negative early components (N100, N200) are involved in the sensory and perceptual processing of a stimulus, whereas late positive component P300 requires conscious attention. Both neuropsychological affective disorders present patients with spinocerebellar ataxia type 1 (SCA1), but underlying mechanisms need further clarification.In this pilot study, we assessed by recording auditory ERPs 16 consecutive SCA1 healthy controls (HC)...
Recently, RAB32 has been identified as possibly linked to Parkinson's disease. We studied the prevalence and clinical correlates of p.Ser71Arg variant in gene a large case series Italian patients with disease or atypical parkinsonism.
Dopamine is involved in sexual behavior, but dopaminergic imaging studies establishing the relationship between nigrostriatal degeneration and dysfunction (SD) Parkinson's disease (PD) are lacking.We retrospectively analyzed clinical 123I-FP-CIT SPECT data of 43 drug-naïve PD patients. Based on function domain Non-Motor Symptoms Scale (NMSS), we identified 23 patients with concerns (WSC), reporting a score ≥ 2 due to hyposexuality, 20 without (NoSC). transporter (DAT) uptake was assessed...
Growing evidence has highlighted that angiotensin-converting enzyme (ACE)-inhibitors (ACEi)/AT1 receptor blockers (ARBs) may influence the complex interplay between dopamine and renin-angiotensin system in nigrostriatal pathway, thus affecting development of levodopa-induced dyskinesia Parkinson's disease (PD). In present study, we analyzed whether use this class medication was associated with a reduced occurrence dyskinesia, using electronically-stored information idiopathic PD patients...