A5017423456- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Amyotrophic Lateral Sclerosis Research
- Glycogen Storage Diseases and Myoclonus
- Pain Mechanisms and Treatments
- Systemic Sclerosis and Related Diseases
- Psychosomatic Disorders and Their Treatments
- Neurogenetic and Muscular Disorders Research
- Obsessive-Compulsive Spectrum Disorders
- Prion Diseases and Protein Misfolding
- Voice and Speech Disorders
- Stuttering Research and Treatment
- Anesthesia and Neurotoxicity Research
- Microbial Metabolism and Applications
- Dysphagia Assessment and Management
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neural Engineering
- Hereditary Neurological Disorders
- Advanced Chemical Sensor Technologies
- Parathyroid Disorders and Treatments
- Nutrition and Health in Aging
- Ion channel regulation and function
- Alkaline Phosphatase Research Studies
Ospedale San Paolo
2022-2024
John Wiley & Sons (United States)
2023-2024
Sapienza University of Rome
2015-2024
University of Bari Aldo Moro
2006-2019
Ospedale A. Perrino
2019
Istituto Neurologico Mediterraneo
2015
University of Udine
2012
<h3>Objective</h3> To investigate the frequency and main clinical features of tremor in primary adult-onset dystonia (PAOD). <h3>Methods</h3> This cross-sectional study was conducted on 429 patients with PAOD from eight Italian movement disorder centres. <h3>Results</h3> Of dystonic patients, 72 (16.7%) had tremor. Although sex age at onset were similar who those did not, affected more often by focal cervical less blepharospasm. Dystonia a greater tendency to spread According Movement...
Abstract Existing scales for rating the severity of blepharospasm (BSP) are limited by a number potential drawbacks. We therefore developed and validated novel scale BSP. The development started with careful examination clinical spectrum condition panel experts who selected phenomenological aspects thought to be relevant disease severity. Thereafter, items were first checked reliability, then reliable combined generate scale, clinimetric properties evaluated. Finally, confidence which could...
To estimate the prevalence of Pisa syndrome (PS) in patients with Parkinson disease (PD) and to assess association between PS demographic clinical variables.In this multicenter cross-sectional study, consecutive outpatients PD attending 21 movement disorders Italian tertiary centers were enrolled underwent standardized evaluation. was defined as trunk lateral deviation ≥10°. Patients compared according presence for several variables.Among 1,631 PD, detected 143 (8.8%, 95% confidence interval...
Abstract SPECT imaging is widely used for the differential diagnosis of degenerative parkinsonisms by exploiting high affinitiy radiotracer 123 I‐FP‐CIT dopamine transporter. Reduced levels DAT are found in Parkinson Disease (PD), Dementia with Lewy Bodies (DLB), and Progressive Supranuclear Palsy (PSP) compared to Essential Tremor (ET) Healthy Controls (HC). However, extent neurodegenerative process may extend beyond nigrostriatal system. We have exploited affinity same serotonin...
Abstract Introduction The recently released classification has revised the nosology of tremor, defining essential tremor (ET) as a syndrome and fueling an enlightened debate about some newly conceptualized entities such ET-plus. As result, precise information demographics, clinical features, natural history these conditions are lacking. Methods ITAlian Network (TITAN) is multicenter data collection platform, aim which to prospectively assess, according standardized protocol, phenomenology...
Abstract Background Tremor disorders remain as clinical diagnoses and the rate of misdiagnosis between commonest non‐parkinsonian tremors is relatively high. Objectives To compare features Essential without other (pure ET), ET plus soft dystonic signs (ET + DS), tremor combined with dystonia (TwD). Methods We compared patients pure ET, DS, TwD enrolled in The ITAlian Network (TITAN). Linear regression models were performed to determine factors associated health status quality life. Results...
Action tremor may occur in patients with Parkinson's disease and cause misdiagnosis other movement disorders such as essential dystonia. Data on the frequency of action relationships motor non-motor signs are limited.A cross-sectional study 237 staging 1-2 Hoehn-Yahr scale was conducted. were collected using Unified Disease Rating Scale part III Non-Motor Symptoms Scale.Action found 46% associated both severity rest (adjusted odds ratio 3.0, P < 0.001) rigidity 1.5, = 0.004). No association...
Objective: This study assessed amyotrophic lateral sclerosis (ALS) incidence in Sardinia, Italy, and the combined contribution of age gender to disease risk. We also checked for spatial-temporal variability. Methods: ALS patients from all neurological centers area who had onset during 2010-2019 fulfilled El Escorial revised diagnostic criteria were included. Incidence was calculated overall each province separately. Additive interaction between sex on assessed. Results: The average crude...
Background and purpose Although female gender, depressive symptoms medical conditions predisposing to pain are more common in patients with Parkinson's disease ( PD ) pain, no study has yet explored the relationship between other non‐motor (NMS). Methods A total of 321 consecutive [190 men/131 women aged 68.3 SD 9.2) years] attending four Italian movement disorder clinics were studied. Demographic/clinical data obtained by a standardized interview NMS scale. The association motor was...
Tremor in dystonia has been described as a postural or kinetic abnormality. In recent series, however, patients with idiopathic adult-onset also displayed rest tremor.The frequency and distribution of tremor were studied cohort 173 consecutive Italian affected by various forms attending our movement disorder clinic over 8 months.Examination revealed 59/173 (34%): 12 had head tremor, 34 arm whilst 13 presented both sites. Head was all patients, whereas postural/kinetic 28 only at one 18...
Abstract Background Blepharospasm ( BSP ) is a type of focal dystonia characterized by involuntary orbicularis oculi spasms that are usually bilateral, synchronous, and symmetrical. Despite strong evidence for genetic contributions to , progress in the field has been constrained small cohorts, incomplete penetrance, late age onset. Although several etiologies have identified through whole‐exome sequencing WES ), none these characteristically associated with as singular or predominant...
Cervical dystonia is characterized by a variable pattern of neck muscle involvement. Due to the lack diagnostic test, cervical diagnosis based on clinical examination and therefore subjective. The present work was designed provide practical guidance for clinicians in confirming or refuting suspected dystonia.Participants were video recorded according standardized protocol assess 6 main features possibly contributing diagnosis: presence repetitive, patterned head/neck movements/postures...
Background Several earlier studies showed a female predominance in idiopathic adult-onset dystonia (IAOD) affecting the craniocervical area and male preponderance limb dystonia. However, sex-related differences may result from bias inherent to study design. Moreover, information is lacking on whether exist expressing other dystonia-associated features spread. Objective To provide accurate relationship between sex differences, motor phenomenology, natural history of IAOD. Methods Data 1701...