A5009537758- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Trigeminal Neuralgia and Treatments
- Pain Mechanisms and Treatments
- Obsessive-Compulsive Spectrum Disorders
- Olfactory and Sensory Function Studies
- Ophthalmology and Eye Disorders
- Facial Nerve Paralysis Treatment and Research
- Psychosomatic Disorders and Their Treatments
- Cell Adhesion Molecules Research
- Transcranial Magnetic Stimulation Studies
- Parkinson's Disease and Spinal Disorders
- Autoimmune Neurological Disorders and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Hereditary Neurological Disorders
- Biochemical Analysis and Sensing Techniques
- Restless Legs Syndrome Research
- Functional Brain Connectivity Studies
- Amyotrophic Lateral Sclerosis Research
- Glycogen Storage Diseases and Myoclonus
- Neurological and metabolic disorders
- Advanced Chemical Sensor Technologies
- Mitochondrial Function and Pathology
University of Bari Aldo Moro
2013-2024
University of Cagliari
2018-2024
John Wiley & Sons (United States)
2023-2024
Azienda Ospedaliero-Universitaria Cagliari
2019-2023
University of Sassari
2022
Istituto Nazionale di Fisica Nucleare, Sezione di Cagliari
2020-2021
Sapienza University of Rome
1998-2020
Ospedale Civile di Voghera
2020
University of Catania
2020
Institute of Neurological Sciences
2017
<h3>Objective</h3> To determine whether pain is more frequent among people with Parkinson disease (PD) than age-matched controls. <h3>Design</h3> Case-control study. <h3>Patients and Methods</h3> Logistic regression models taking into account type of pain, time between PD onset, possible confounders were used to compare 402 patients 317 healthy control subjects. <h3>Results</h3> The overall frequency was significantly greater in controls (281 [69.9%] vs 199 [62.8%];<i>P</i> = .04), mainly...
Camptocormia is an abnormal flexion of the thoracolumbar spine during standing and walking that abates in recumbent position.In a single-centre epidemiological clinical study, prevalence camptocormia Parkinson disease (PD) its relationship with features PD were investigated. A total 275 consecutive outpatients systematically screened for evaluation. Patients who positive subsequently reassessed by formal goniometric analysis. The demographic patients without then compared.A 6.9% (19/275, 95%...
To determine whether somatosensory temporal discrimination will reliably detect subclinical sensory impairment in patients with various forms of primary focal dystonia.The threshold (STDT) was tested 82 outpatients affected by cranial, cervical, laryngeal and hand dystonia. Results were compared those for 61 healthy subjects 26 hemifacial spasm, a non-dystonic disorder. STDT delivering paired stimuli starting an interstimulus interval 0 ms followed progressively increasing interval.STDT...
To investigate whether (1) phosphorylated α-synuclein (p-syn) deposits in skin nerves could be useful differentiating dementia with Lewy bodies (DLB) from different forms of and (2) small fiber neuropathy (SFN) is associated DLB.We studied 18 well-characterized patients DLB (11 autonomic dysfunction), 23 nonsynucleinopathy (NSD; 13 young-onset Alzheimer disease dementia, 6 frontotemporal 4 vascular dementia), 25 healthy controls. All participants underwent biopsies proximal (i.e., cervical)...
Among different exercise models proposed for individuals with Parkinson's disease (IwPD), the popularity of traditional forms dance is increasing. The aim this study was to evaluate effects Sardinian folk (Ballu Sardu, BS) on functional performance and motor nonmotor symptoms in IwPD.Single-blind, randomized controlled pilot trial.Outpatient health clinic.Twenty IwPD (13M, 7F; 67.4 ± 6.1 years) were randomly assigned BS (n = 10) or usual care 10). program consisted two sessions/week,...
Qualitative smell/taste disorders (such as phantosmia, parosmia, phantogeusia, and parageusia) have not yet been fully characterized in patients who had COVID-19, whereas quantitative disturbances (i.e., reduction/loss of smell/taste) widely investigated.To simultaneously assess the presence both qualitative dysfunctions suffered from COVID-19.We enrolled 17 consecutive COVID-19 over last 6 months 21 healthy controls, matched for sex age. After a negative nasopharyngeal swab, Sniffin' Sticks...
Olfactory and cognitive disorders represent important non-motor symptoms in Parkinson's disease (PD). No clear evidence was reported about association of specific domains olfactory impairment.The aim this study to evaluate the between dysfunction PD patients compared controls.178 98 controls were enrolled evaluated for odor threshold (OT), discrimination (OD), identification (OI), TDI score using Sniffin' Sticks test. Cognitive function Montreal Assessment scale with six sub-scores:...
<h3>Background</h3> Botulinum toxin A (BTX) is the currently preferred symptomatic treatment for primary hemifacial spasm (HFS), but its long-term efficacy and safety are not known. <h3>Objective</h3> To assess effectiveness of BTX in HFS. <h3>Design</h3> Retrospective review medical records 1st 10th years treatment. <h3>Setting</h3> Outpatient clinics 4 Italian university centers Movement Disorders Study Group. <h3>Participants</h3> series 65 patients with HFS who had received injections...
DYT1 primary torsion dystonia is an autosomal dominant movement disorder due to a 3-bp GAG deletion in the TOR1A gene, which becomes manifest only 30-40% of mutation carriers. Investigating factors regulating this reduced penetrance might add new insight into mechanisms underlying disease. The pathophysiology has been related basal ganglia dysfunctions that lead most prominent motor symptoms. However, subclinical sensory deficits have also reported, particularly adult-onset focal dystonia....
Background: Hemifacial spasm (HFS) is a common movement disorder.Objective: To evaluate possible differences in the demographic and clinical features between primary secondary HFS.Design: In-person interview using standardized questionnaire to collect data.Setting: A multicenter study that included patients with HFS attending 3 Italian academic centers.Patients: Two hundred fourteen HFS.Main Outcome Measure: complete neurological examination assessed current muscle distribution of presence...
Abstract A form of fixed dystonia (FD) without evidence basal ganglia lesions or neurodegeneration has been recently characterized (Schrag et al., Brain 2004;127:2360‐2372), which may overlap the clinical spectrum either complex regional pain syndrome psychogenic dystonia. Transcranial magnetic stimulation studies in typically mobile revealed abnormal motor cortical excitability and sensori‐motor integration. We compared 12 patients with limb FD to 10 primary adult‐onset 11 age‐matched...
Diffusion tensor imaging (DTI) analyses the movement of water molecules within cerebral white matter thus providing information on ultrastructural brain changes. We studied 18 patients with cervical dystonia (CD), 16 blepharospasm (BSP) and 35 years age-matched healthy controls. DTI data were obtained a Philips 1.5 Tesla scanner then processed to obtain maps fractional anisotropy (FA) mean diffusivity (MD). Twenty-three square regions interest uniform size positioned FA automatically...
Cervical dystonia (CD), the most common form of adult-onset focal dystonia, has a heterogeneous clinical presentation with variable features, leading to difficulties and delays in diagnosis. Owing lack reviews specifically focusing on frequency primary CD general population, we performed systematic literature search examine its prevalence/incidence analyze methodological differences among studies.We prevalence data CD. Sixteen articles met our criteria. Because reported estimates were found...
The number of existing cases primary dystonia in the population is not precisely known, but condition probably much more frequent than reported. By minimum prevalence estimates, should be considered third most movement disorders after essential tremor and Parkinson’s disease. likely etiologic scenario suggested by epidemiological data that dystonias are products a genetic background an environmental insult. Current information on causation dystonia, late‐onset particular, often unreliable...
Abstract Existing scales for rating the severity of blepharospasm (BSP) are limited by a number potential drawbacks. We therefore developed and validated novel scale BSP. The development started with careful examination clinical spectrum condition panel experts who selected phenomenological aspects thought to be relevant disease severity. Thereafter, items were first checked reliability, then reliable combined generate scale, clinimetric properties evaluated. Finally, confidence which could...