A5102782863- Transcranial Magnetic Stimulation Studies
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Motor Control and Adaptation
- Muscle activation and electromyography studies
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Cerebral Palsy and Movement Disorders
- Balance, Gait, and Falls Prevention
- Vestibular and auditory disorders
- EEG and Brain-Computer Interfaces
- Stroke Rehabilitation and Recovery
- Action Observation and Synchronization
- Neurological diseases and metabolism
- Trigeminal Neuralgia and Treatments
- Mitochondrial Function and Pathology
- Tactile and Sensory Interactions
- Advanced Neuroimaging Techniques and Applications
- Neurology and Historical Studies
- Hereditary Neurological Disorders
- Facial Nerve Paralysis Treatment and Research
- Autism Spectrum Disorder Research
- Porphyrin Metabolism and Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Children's Physical and Motor Development
University of Genoa
2013-2022
Ospedale Policlinico San Martino
2015-2020
CUNY School of Law
2009
Istituto Nazionale di Fisica Nucleare
2009
University of Bari Aldo Moro
2000-2003
University of Messina
2003
Institute of Neurological Sciences
1997
It has been postulated that sensorimotor integration is abnormal in dystonia. We investigated changes motor cortical excitability induced by peripheral stimulation patients with focal hand dystonia (12 cramps) and cervical (nine spasmodic torticollis) compared 16 age-matched normal controls. Motor evoked potentials (MEP) to (figure-of-eight coil) transcranial magnetic of the area were recorded from right abductor pollicis brevis (APB), first dorsal interosseus (FDI), flexor carpi radialis...
Corticobasal degeneration is a sporadic form of tauopathy, involving the cerebral cortex and extrapyramidal motor system. A series affected subjects was genotyped for set genetic markers along tau protein gene. specific haplotype significantly overrepresented in patients versus controls. This same already reported association with progressive supranuclear palsy. These data show that corticobasal palsy, addition to several clinical, pathological, molecular features, may have background.
Freezing of gait (FOG) is a disabling impairment for people with Parkinson's disease (PD) and may not respond to medications. The effectiveness physical therapy FOG debatable. Action observation strategies overcome enhance training.To assess whether action observation, combined practicing the observed actions, reduce episodes.Twenty patients PD entered single-blind trial were randomly assigned experimental (Action) or control (Landscape) groups. Those in group watched video clips showing...
Recent work has demonstrated that fall risk can be attributed to cognitive as well motor deficits. Indeed, everyday walking in complex environments utilizes executive function, dual tasking, planning and scanning, all while forward. Pilot studies suggest a multi-modal intervention combines treadmill training target function virtual reality obstacle course address the components of may used successfully motor-cognitive interactions are fundamental for reduction. The proposed randomized...
Deferiprone was shown to reverse iron deposition in Friedreich’s ataxia. This multi-center, unblinded, single-arm pilot study evaluated safety and efficacy of deferiprone for reducing cerebral accumulation neurodegeneration with brain accumulation. Four patients genetically-confirmed pantothenate kinase-associated neurodegeneration, 2 parkinsonism focal dystonia, but inconclusive genetic tests, received 15 mg/kg bid. Magnetic resonance imaging neurological examinations were conducted at...
Optimal management in expert centers for Parkinson's disease (PD) usually involves pharmacological and non-pharmacological interventions, delivered by a multidisciplinary approach. However, there is no guideline specifying how this model should be organized. Consequently, the nature of care varies widely.
Corticobasal degeneration is a sporadic form of tauopathy, involving the cerebral cortex and extrapyramidal motor system. A series affected subjects was genotyped for set genetic markers along tau protein gene. specific haplotype significantly overrepresented in patients versus controls. This same already reported association with progressive supranuclear palsy. These data show that corticobasal palsy, addition to several clinical, pathological, molecular features, may have background. Ann...
<h3>Background</h3> Botulinum toxin A (BTX) is the currently preferred symptomatic treatment for primary hemifacial spasm (HFS), but its long-term efficacy and safety are not known. <h3>Objective</h3> To assess effectiveness of BTX in HFS. <h3>Design</h3> Retrospective review medical records 1st 10th years treatment. <h3>Setting</h3> Outpatient clinics 4 Italian university centers Movement Disorders Study Group. <h3>Participants</h3> series 65 patients with HFS who had received injections...
1. The responses of the brachioradialis and biceps brachii muscles to non-invasive magnetic electrical stimulation human motor cortex have been investigated during performance different tasks. 2. Both were simultaneously active elbow flexor isometric torque, or forearm flexion lifting a weight (shortening contraction), extension breaking fall (lengthening contraction). extensor triceps muscle was not engaged in any task. By using weights, comparable levels EMG activity obtained same across...
Abstract A form of fixed dystonia (FD) without evidence basal ganglia lesions or neurodegeneration has been recently characterized (Schrag et al., Brain 2004;127:2360‐2372), which may overlap the clinical spectrum either complex regional pain syndrome psychogenic dystonia. Transcranial magnetic stimulation studies in typically mobile revealed abnormal motor cortical excitability and sensori‐motor integration. We compared 12 patients with limb FD to 10 primary adult‐onset 11 age‐matched...
This study investigated how Parkinson's disease alters haptic perception and the underlying mechanisms of somatosensory sensorimotor integration. Changes in sensitivity acuity (the abilities to detect discriminate between stimuli) due were systematically quantified contrasted performance healthy older young adults. Using a robotic force environment, virtual contours various curvatures presented. Participants explored these with their hands indicated verbally whether they could or two...
Background. Action observation influences motor performance in healthy subjects and persons with impairments. Objective. To understand the effects of action on spontaneous rate finger movements patients Parkinson disease (PD). Methods. Participants, 20 PD 14 controls, were randomly divided into 2 groups. Those VIDEO group watched video clips showing repetitive paced at 3 Hz, whereas those ACOUSTIC listened to an acoustic cue Hz. All participants performed a sequence their pace different...