A5087471580- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Functional Brain Connectivity Studies
- Sleep and Wakefulness Research
- Cell death mechanisms and regulation
- Ion channel regulation and function
- Neural and Behavioral Psychology Studies
- Neurotransmitter Receptor Influence on Behavior
- Neural dynamics and brain function
- Nutrition, Genetics, and Disease
- Botulinum Toxin and Related Neurological Disorders
- Cancer, Lipids, and Metabolism
- Eating Disorders and Behaviors
- Cannabis and Cannabinoid Research
- COVID-19 impact on air quality
- Diet, Metabolism, and Disease
- RNA regulation and disease
- Obsessive-Compulsive Spectrum Disorders
- Nerve injury and regeneration
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Autophagy in Disease and Therapy
National Institute on Drug Abuse
2018-2025
Center for Neuroscience and Cognitive Systems
2023
University of Siena
2023
PENTA Foundation
2019-2022
Ospedale Infermi di Rimini
2022
University of Rome Tor Vergata
2008-2019
Fondazione Santa Lucia
2008-2019
Micro Focus (United States)
2019
National Institutes of Health
2018-2019
Istituti di Ricovero e Cura a Carattere Scientifico
2010-2019
Work over the past two decades revealed a previously unexpected role for striatal cholinergic interneurons in context of basal ganglia function. The recognition that these are essential synaptic plasticity and motor learning represents significant step ahead deciphering how striatum processes cortical inputs, why pathological circumstances cause dysfunction. Loss reciprocal modulation between dopaminergic inputs intrinsic innervation within appears to be trigger pathophysiological changes...
Highlights•Clinical and research NIBS operations are important in some cases critical to continue through the COVID-19 pandemic.•We provide a framework for maintaining their safety during future outbreaks.•Guidelines good practices managing reopening clinics laboratories presented.•Remotely supervised tDCS provides opportunity clinical treatments patients at home while staff offsite.•Onsite brain stimulation, such as TMS, can proceed when implementing workflows ensuring related...
Projections from thalamic intralaminar nuclei convey sensory signals to striatal cholinergic interneurons. These neurons respond with a pause in their pacemaking activity, enabling synaptic integration cortical inputs medium spiny (MSNs), thus playing crucial role motor function. In mice the DYT1 dystonia mutation, stimulation of thalamostriatal axons, mimicking response salient events, evoked shortened and triggered an abnormal spiking activity This altered pattern caused significant...
Broad-spectrum muscarinic receptor antagonists have represented the first available treatment for different movement disorders such as dystonia. However, specificity of these drugs and their mechanism action is not entirely clear. We performed a systematic analysis effects anticholinergic on short- long-term plasticity recorded from striatal medium spiny neurons DYT1 dystonia knock-in (Tor1a(+/Δgag) ) mice heterozygous ΔE-torsinA controls (Tor1a(+/+) mice). Antagonists were chosen that had...
To estimate the prevalence of Pisa syndrome (PS) in patients with Parkinson disease (PD) and to assess association between PS demographic clinical variables.In this multicenter cross-sectional study, consecutive outpatients PD attending 21 movement disorders Italian tertiary centers were enrolled underwent standardized evaluation. was defined as trunk lateral deviation ≥10°. Patients compared according presence for several variables.Among 1,631 PD, detected 143 (8.8%, 95% confidence interval...
Background DYT1 dystonia, a severe form of genetically determined human exhibits reduced penetrance among carriers and begins usually during adolescence. The reasons for such age dependence variability remain unclear. Methods Results We characterized the alterations in D2 dopamine receptor (D2R) signalling striatal cholinergic interneurons at different ages mice overexpressing mutant torsinA (hMT). An abnormal excitatory response to D2R agonist quinpirole was recorded postnatal day 14,...
Abstract Alterations of striatal synaptic transmission have been associated with several motor disorders involving the basal ganglia, such as Parkinson’s disease. For this reason, we investigated role group‐III metabotropic glutamate (mGlu) receptors in regulating striatum by electrophysiological recordings and using our novel orthosteric agonist (3 S )‐3‐[(3‐amino‐3‐carboxypropyl(hydroxy)phosphinyl)‐hydroxymethyl]‐5‐nitrothiophene (LSP1‐3081) l ‐2‐amino‐4‐phosphonobutanoate (L‐AP4). Here,...
Lymphocyte activation gene 3 (LAG3) is a key receptor involved in the propagation of pathological proteins Parkinson disease (PD). This study investigates role neuronal LAG3 mediating binding, uptake, and alpha-synuclein (aSyn) preformed fibrils (PFFs). Using conditional knockout mice human induced pluripotent stem cells-derived dopaminergic (DA) neurons, we demonstrate that expression critical for pathogenic aSyn propagation. Our results show absence significantly reduces pathology,...
ABSTRACT Homozygous or compound heterozygous mutations in the phosphatase and tensin homolog‐induced putative kinase 1 ( PINK1 ) gene are causative of autosomal recessive, early onset Parkinson's disease. Single have been detected repeatedly both a subset patients unaffected individuals, significance these has long debated. Several neurophysiological studies from non‐manifesting heterozygotes demonstrated existence neural plasticity abnormalities, indicating presence specific endophenotypic...
Significance Parkinson’s disease (PD) is a chronic dopamine (DA) neuron degenerative disorder. Little known about factors that impact vulnerability of DA neurons to pathological insults. In this study, we found vesicular glutamate transporter 2 (VgluT2) expression may play an important role in protecting neurons. Selective deletion VgluT2 led significant reduction brain-derived neurotrophic factor and its receptor tyrosine kinase B increase death caused by the neurotoxin...
Idiopathic normal pressure hydrocephalus (iNPH) can be misdiagnosed with other neurodegenerative diseases, especially in the early disease stages. Considering opportunity of shunt surgery, iNPH should diagnosed accuracy. Here, we evaluate utility CSF biomarkers and their relationship clinical features diagnosis iNPH.We performed a multivariate analysis levels Aβ42, t-tau, p-tau collected from four groups patients: 14 iNPH, progressive supranuclear palsy (PSP), Alzheimer's (AD), controls...
Background: Cocaine is a psychostimulant drug used as performance enhancer throughout history. The prolonged use of cocaine associated with addiction and broad range cognitive deficits. Currently, there are no medications proven to be effective for cocaine-use disorder (CocUD). Previous preliminary clinical work suggests some benefit from repetitive transcranial magnetic stimulation (rTMS) stimulating the prefrontal cortex (PFC), involved in inhibitory control, decision-making attention. All...
Caspases are a family of conserved cysteine proteases that play key roles in multiple cellular processes, including programmed cell death and inflammation. Recent evidence shows caspases also involved crucial non-apoptotic functions, such as dendrite development, axon pruning, synaptic plasticity mechanisms underlying learning memory processes. The activated form caspase-3, which is known to trigger widespread damage degeneration, can modulate function the adult brain. Thus, present study,...